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A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
Skovronsky DM, Pijak DS, Doms RW, Lee VM. Skovronsky DM, et al. Among authors: pijak ds. Biochemistry. 2000 Feb 1;39(4):810-7. doi: 10.1021/bi991728z. Biochemistry. 2000. PMID: 10651647
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.
Fortna RR, Crystal AS, Morais VA, Pijak DS, Lee VM, Doms RW. Fortna RR, et al. Among authors: pijak ds. J Biol Chem. 2004 Jan 30;279(5):3685-93. doi: 10.1074/jbc.M310505200. Epub 2003 Oct 30. J Biol Chem. 2004. PMID: 14593096 Free article.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW. Morais VA, et al. Among authors: pijak ds. J Biol Chem. 2003 Oct 31;278(44):43284-91. doi: 10.1074/jbc.M305685200. Epub 2003 Aug 12. J Biol Chem. 2003. PMID: 12917438 Free article.
Membrane topology of gamma-secretase component PEN-2.
Crystal AS, Morais VA, Pierson TC, Pijak DS, Carlin D, Lee VM, Doms RW. Crystal AS, et al. Among authors: pijak ds. J Biol Chem. 2003 May 30;278(22):20117-23. doi: 10.1074/jbc.M213107200. Epub 2003 Mar 14. J Biol Chem. 2003. PMID: 12639958 Free article.
Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
Huse JT, Liu K, Pijak DS, Carlin D, Lee VM, Doms RW. Huse JT, et al. Among authors: pijak ds. J Biol Chem. 2002 May 3;277(18):16278-84. doi: 10.1074/jbc.M111141200. Epub 2002 Feb 14. J Biol Chem. 2002. PMID: 11847218 Free article.
Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
Huse JT, Byant D, Yang Y, Pijak DS, D'Souza I, Lah JJ, Lee VM, Doms RW, Cook DG. Huse JT, et al. Among authors: pijak ds. J Biol Chem. 2003 May 9;278(19):17141-9. doi: 10.1074/jbc.M213303200. Epub 2003 Jan 27. J Biol Chem. 2003. PMID: 12551920 Free article.
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.
Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW. Huse JT, et al. Among authors: pijak ds. J Biol Chem. 2000 Oct 27;275(43):33729-37. doi: 10.1074/jbc.M004175200. J Biol Chem. 2000. PMID: 10924510 Free article.
N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53.
Morais VA, Brito C, Pijak DS, Crystal AS, Fortna RR, Li T, Wong PC, Doms RW, Costa J. Morais VA, et al. Among authors: pijak ds. Biochim Biophys Acta. 2006 Sep;1762(9):802-10. doi: 10.1016/j.bbadis.2006.06.018. Epub 2006 Jul 26. Biochim Biophys Acta. 2006. PMID: 16938437 Free article.
Cellular localization of Nicastrin affects amyloid beta species production.
Morais VA, Leight S, Pijak DS, Lee VM, Costa J. Morais VA, et al. Among authors: pijak ds. FEBS Lett. 2008 Feb 6;582(3):427-33. doi: 10.1016/j.febslet.2008.01.003. Epub 2008 Jan 15. FEBS Lett. 2008. PMID: 18201567 Free article.
Neurofilament spacing, phosphorylation, and axon diameter in regenerating and uninjured lamprey axons.
Pijak DS, Hall GF, Tenicki PJ, Boulos AS, Lurie DI, Selzer ME. Pijak DS, et al. J Comp Neurol. 1996 May 13;368(4):569-81. doi: 10.1002/(SICI)1096-9861(19960513)368:4<569::AID-CNE8>3.0.CO;2-2. J Comp Neurol. 1996. PMID: 8744444
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