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Page 1
Natural Sources and Pharmacological Properties of Pinosylvin.
Bakrim S, Machate H, Benali T, Sahib N, Jaouadi I, Omari NE, Aboulaghras S, Bangar SP, Lorenzo JM, Zengin G, Montesano D, Gallo M, Bouyahya A. Bakrim S, et al. Plants (Basel). 2022 Jun 9;11(12):1541. doi: 10.3390/plants11121541. Plants (Basel). 2022. PMID: 35736692 Free PMC article. Review.
Pinosylvin (3,5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of Pinus spp. ...The collected data on pinosylvin was managed using different scientifi …
Pinosylvin (3,5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally …
Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation.
Kivimäki K, Leppänen T, Hämäläinen M, Vuolteenaho K, Moilanen E. Kivimäki K, et al. Molecules. 2021 May 8;26(9):2772. doi: 10.3390/molecules26092772. Molecules. 2021. PMID: 34066748 Free PMC article.
Pinosylvin is a natural stilbenoid found particularly in Scots pine. ...In IL-4-treated macrophages, pinosylvin enhanced PPAR-gamma expression but had no effect on STAT6 phosphorylation. ...
Pinosylvin is a natural stilbenoid found particularly in Scots pine. ...In IL-4-treated macrophages, pinosylvin enhanced PPAR- …
Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes.
Kwon O, Seo Y, Park H. Kwon O, et al. BMB Rep. 2018 Jun;51(6):302-307. doi: 10.5483/bmbrep.2018.51.6.024. BMB Rep. 2018. PMID: 29555013 Free PMC article.
Pinosylvin is known to have anti-inflammatory activity in endothelial cells. ...LOX activity was found to be markedly increased by pinosylvin, whereas COX activity was not altered. Furthermore, we found that pinosylvin enhanced both levels of ALOX 15 mRNA and …
Pinosylvin is known to have anti-inflammatory activity in endothelial cells. ...LOX activity was found to be markedly increased by …
Pinosylvin enhances leukemia cell death via down-regulation of AMPKalpha expression.
Song J, Seo Y, Park H. Song J, et al. Phytother Res. 2018 Oct;32(10):2097-2104. doi: 10.1002/ptr.6156. Epub 2018 Jul 20. Phytother Res. 2018. PMID: 30027566
These data indicate that pinosylvin-induced cell death may occur through apoptosis and autophagy. In addition, we showed that pinosylvin down-regulates AMP-activated protein kinase alpha1 (AMPKalpha1) in leukemia cells. ...
These data indicate that pinosylvin-induced cell death may occur through apoptosis and autophagy. In addition, we showed that pino …
Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial-mesenchymal transition and inhibition of MMP-2.
Chuang YC, Hsieh MC, Lin CC, Lo YS, Ho HY, Hsieh MJ, Lin JT. Chuang YC, et al. Oncol Rep. 2021 Jul;46(1):143. doi: 10.3892/or.2021.8094. Epub 2021 Jun 3. Oncol Rep. 2021. PMID: 34080661 Free PMC article.
The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC-039 and NPC-BM cells …
The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure an …
Pinosylvin induces cell survival, migration and anti-adhesiveness of endothelial cells via nitric oxide production.
Jeong E, Lee HR, Pyee J, Park H. Jeong E, et al. Phytother Res. 2013 Apr;27(4):610-7. doi: 10.1002/ptr.4770. Epub 2012 Jun 27. Phytother Res. 2013. PMID: 22736379
Pinosylvin is a phenolic compound mainly found in the Pinus species. To determine the vascular functions of pinosylvin, we first examined both proliferation and apoptosis of bovine aortic endothelial cells (BAECs) in the presence of pinosylvin. ...
Pinosylvin is a phenolic compound mainly found in the Pinus species. To determine the vascular functions of pinosylvin, we fir …
Pinosylvin reduced migration and invasion of oral cancer carcinoma by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway.
Chen MK, Liu YT, Lin JT, Lin CC, Chuang YC, Lo YS, Hsi YT, Hsieh MJ. Chen MK, et al. Biomed Pharmacother. 2019 Sep;117:109160. doi: 10.1016/j.biopha.2019.109160. Epub 2019 Jul 1. Biomed Pharmacother. 2019. PMID: 31387166 Free article.
BACKGROUND: Pinosylvin possesses several biological properties, including anti-inflammatory, antitumor, and antioxidant characteristics. ...Besides, pinosylvin decreased the phosphorylation of ERK1/2 protein experssion in both SAS and SCC-9 cells. ...
BACKGROUND: Pinosylvin possesses several biological properties, including anti-inflammatory, antitumor, and antioxidant characteristi …
Efficient biosynthesis of pinosylvin from lignin-derived cinnamic acid by metabolic engineering of Escherichia coli.
Hu Y, Zhang C, Zou L, Zheng Z, Ouyang J. Hu Y, et al. Biotechnol Biofuels Bioprod. 2022 Dec 12;15(1):136. doi: 10.1186/s13068-022-02236-5. Biotechnol Biofuels Bioprod. 2022. PMID: 36503554 Free PMC article.
The expression of Ptr4CL4 drastically improved the production of pinosylvin (42.5 1.1 mg/L), achieving values 15.7-fold higher than that of Ptr4CL5 (another 4-Coumarate-CoA ligase from Populus trichocarpa) in the absence of cerulenin. ...This is the highest reported pin …
The expression of Ptr4CL4 drastically improved the production of pinosylvin (42.5 1.1 mg/L), achieving values 15.7-fold higher than t …
Production of Nematicidal Pinosylvin Stilbenes in Cell Suspension Cultures of Pinus koraiensis by Fungal Elicitation.
Kim YR, Han JY, Choi YE. Kim YR, et al. Plants (Basel). 2022 Oct 31;11(21):2933. doi: 10.3390/plants11212933. Plants (Basel). 2022. PMID: 36365388 Free PMC article.
Pinosylvin stilbenes are natural phenolic compounds found in the Pinaceae family and act as phytoalexins. ...Here, we established the efficient production of two pinosylvin stilbenes, dihydropinosylvin monomethylether (DPME) and pinosylvin monomethylether (PM …
Pinosylvin stilbenes are natural phenolic compounds found in the Pinaceae family and act as phytoalexins. ...Here, we established the …
Inhibitory Mechanism of Pinosylvin Monomethyl Ether against Aspergillus flavus.
Li X, Yao L, Xiong B, Wu Y, Chen S, Xu Z, Qiu SX. Li X, et al. J Agric Food Chem. 2022 Dec 21;70(50):15840-15847. doi: 10.1021/acs.jafc.2c07240. Epub 2022 Nov 30. J Agric Food Chem. 2022. PMID: 36448783
Here, six stilbenes isolated from Cajanus cajan were screened for anti-A. flavus activity. Among them, pinosylvin monomethyl ether (PME) showed the strongest anti-A. flavus activity and has a broad antifungal spectrum with negligible hemolysis within the concentration rang …
Here, six stilbenes isolated from Cajanus cajan were screened for anti-A. flavus activity. Among them, pinosylvin monomethyl ether (P …
164 results