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Natural Sources and Pharmacological Properties of Pinosylvin.
Bakrim S, Machate H, Benali T, Sahib N, Jaouadi I, Omari NE, Aboulaghras S, Bangar SP, Lorenzo JM, Zengin G, Montesano D, Gallo M, Bouyahya A. Bakrim S, et al. Plants (Basel). 2022 Jun 9;11(12):1541. doi: 10.3390/plants11121541. Plants (Basel). 2022. PMID: 35736692 Free PMC article. Review.
Pinosylvin (3,5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of Pinus spp. ...The collected data on pinosylvin was managed using different scientifi …
Pinosylvin (3,5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally …
Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation.
Kivimäki K, Leppänen T, Hämäläinen M, Vuolteenaho K, Moilanen E. Kivimäki K, et al. Molecules. 2021 May 8;26(9):2772. doi: 10.3390/molecules26092772. Molecules. 2021. PMID: 34066748 Free PMC article.
Pinosylvin is a natural stilbenoid found particularly in Scots pine. ...In IL-4-treated macrophages, pinosylvin enhanced PPAR-gamma expression but had no effect on STAT6 phosphorylation. ...
Pinosylvin is a natural stilbenoid found particularly in Scots pine. ...In IL-4-treated macrophages, pinosylvin enhanced PPAR- …
Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes.
Kwon O, Seo Y, Park H. Kwon O, et al. BMB Rep. 2018 Jun;51(6):302-307. doi: 10.5483/bmbrep.2018.51.6.024. BMB Rep. 2018. PMID: 29555013 Free PMC article.
Pinosylvin is known to have anti-inflammatory activity in endothelial cells. ...LOX activity was found to be markedly increased by pinosylvin, whereas COX activity was not altered. Furthermore, we found that pinosylvin enhanced both levels of ALOX 15 mRNA and …
Pinosylvin is known to have anti-inflammatory activity in endothelial cells. ...LOX activity was found to be markedly increased by …
Pinosylvin enhances leukemia cell death via down-regulation of AMPKα expression.
Song J, Seo Y, Park H. Song J, et al. Phytother Res. 2018 Oct;32(10):2097-2104. doi: 10.1002/ptr.6156. Epub 2018 Jul 20. Phytother Res. 2018. PMID: 30027566
These data indicate that pinosylvin-induced cell death may occur through apoptosis and autophagy. In addition, we showed that pinosylvin down-regulates AMP-activated protein kinase alpha1 (AMPKalpha1) in leukemia cells. ...
These data indicate that pinosylvin-induced cell death may occur through apoptosis and autophagy. In addition, we showed that pino …
Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2.
Chuang YC, Hsieh MC, Lin CC, Lo YS, Ho HY, Hsieh MJ, Lin JT. Chuang YC, et al. Oncol Rep. 2021 Jul;46(1):143. doi: 10.3892/or.2021.8094. Epub 2021 Jun 3. Oncol Rep. 2021. PMID: 34080661 Free PMC article.
The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC-039 and NPC-BM cells …
The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure an …
Efficient biosynthesis of pinosylvin from lignin-derived cinnamic acid by metabolic engineering of Escherichia coli.
Hu Y, Zhang C, Zou L, Zheng Z, Ouyang J. Hu Y, et al. Biotechnol Biofuels Bioprod. 2022 Dec 12;15(1):136. doi: 10.1186/s13068-022-02236-5. Biotechnol Biofuels Bioprod. 2022. PMID: 36503554 Free PMC article.
The expression of Ptr4CL4 drastically improved the production of pinosylvin (42.5 1.1 mg/L), achieving values 15.7-fold higher than that of Ptr4CL5 (another 4-Coumarate-CoA ligase from Populus trichocarpa) in the absence of cerulenin. ...This is the highest reported pin …
The expression of Ptr4CL4 drastically improved the production of pinosylvin (42.5 1.1 mg/L), achieving values 15.7-fold higher than t …
Production of Nematicidal Pinosylvin Stilbenes in Cell Suspension Cultures of Pinus koraiensis by Fungal Elicitation.
Kim YR, Han JY, Choi YE. Kim YR, et al. Plants (Basel). 2022 Oct 31;11(21):2933. doi: 10.3390/plants11212933. Plants (Basel). 2022. PMID: 36365388 Free PMC article.
Pinosylvin stilbenes are natural phenolic compounds found in the Pinaceae family and act as phytoalexins. ...Here, we established the efficient production of two pinosylvin stilbenes, dihydropinosylvin monomethylether (DPME) and pinosylvin monomethylether (PM …
Pinosylvin stilbenes are natural phenolic compounds found in the Pinaceae family and act as phytoalexins. ...Here, we established the …
Inhibitory Mechanism of Pinosylvin Monomethyl Ether against Aspergillus flavus.
Li X, Yao L, Xiong B, Wu Y, Chen S, Xu Z, Qiu SX. Li X, et al. J Agric Food Chem. 2022 Dec 21;70(50):15840-15847. doi: 10.1021/acs.jafc.2c07240. Epub 2022 Nov 30. J Agric Food Chem. 2022. PMID: 36448783
Here, six stilbenes isolated from Cajanus cajan were screened for anti-A. flavus activity. Among them, pinosylvin monomethyl ether (PME) showed the strongest anti-A. flavus activity and has a broad antifungal spectrum with negligible hemolysis within the concentration rang …
Here, six stilbenes isolated from Cajanus cajan were screened for anti-A. flavus activity. Among them, pinosylvin monomethyl ether (P …
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice.
Tamminen T, Koskela A, Toropainen E, Gurubaran IS, Winiarczyk M, Liukkonen M, Paterno JJ, Lackman P, Sadeghi A, Viiri J, Hyttinen JMT, Koskelainen A, Kaarniranta K. Tamminen T, et al. Oxid Med Cell Longev. 2021 Dec 7;2021:8028427. doi: 10.1155/2021/8028427. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34917233 Free PMC article.
In this work, the effects of commercial natural pinosylvin extract, Retinari, were studied on the electroretinogram, optical coherence tomogram, autophagic activity, antioxidant capacity, and inflammation markers. ...They were fed with either regular or Retinari chow (141 …
In this work, the effects of commercial natural pinosylvin extract, Retinari, were studied on the electroretinogram, optical coherenc …
Enhanced production of pinosylvin stilbene with aging of Pinus strobus callus and nematicidal activity of callus extracts against pinewood nematodes.
Koo HB, Hwang HS, Han JY, Cheong EJ, Kwon YS, Choi YE. Koo HB, et al. Sci Rep. 2022 Jan 14;12(1):770. doi: 10.1038/s41598-022-04843-6. Sci Rep. 2022. PMID: 35031682 Free PMC article.
Pinosylvin stilbenes are phenolic compounds mainly occurring in the Pinaceae family. We previously reported that the accumulation of two pinosylvin stilbene compounds, dihydropinosylvin methyl ether (DPME) and pinosylvin monomethyl ether (PME), in Pinus strob …
Pinosylvin stilbenes are phenolic compounds mainly occurring in the Pinaceae family. We previously reported that the accumulation of …
148 results