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Progress in melanoma histopathology and diagnosis.
Piris A, Mihm MC Jr. Piris A, et al. Hematol Oncol Clin North Am. 2009 Jun;23(3):467-80, viii. doi: 10.1016/j.hoc.2009.03.012. Hematol Oncol Clin North Am. 2009. PMID: 19464597 Review.
The limitations of morphology for the "so called" borderline lesions are briefly discussed, with a list of diagnostic criteria to help predict behavior for these challenging lesions. ...
The limitations of morphology for the "so called" borderline lesions are briefly discussed, with a list of diagnostic criteria to hel …
Mechanisms of metastasis: seed and soil.
Piris A, Mihm MC Jr. Piris A, et al. Cancer Treat Res. 2007;135:119-27. doi: 10.1007/978-0-387-69219-7_9. Cancer Treat Res. 2007. PMID: 17953412 Review. No abstract available.
Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients.
Mochel MC, Hammond MR, Frederick DT, Alora-Palli MB, Piris A, Flaherty KT, Hoang MP. Mochel MC, et al. Among authors: piris a. J Am Acad Dermatol. 2015 Sep;73(3):491-9.e2. doi: 10.1016/j.jaad.2015.06.006. Epub 2015 Jul 16. J Am Acad Dermatol. 2015. PMID: 26190239
The lesions were BRAFV600E and neuroblastoma RAS viral (v-ras) oncogene homolog wild-type, expressed diffuse weak-moderate pERK, and possessed a predominance of CD8(+) in comparison with CD4(+) T lymphocytes within the dermal infiltrates. LIMITATION: This is a retro …
The lesions were BRAFV600E and neuroblastoma RAS viral (v-ras) oncogene homolog wild-type, expressed diffuse weak-moderate pERK, and possess …
BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations.
Piris A, Mihm MC Jr, Hoang MP. Piris A, et al. Hum Pathol. 2015 Feb;46(2):239-45. doi: 10.1016/j.humpath.2014.10.015. Epub 2014 Nov 4. Hum Pathol. 2015. PMID: 25479927
BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene whose mutations have recently been reported to increase susceptibility for the development of uveal melanoma, cutaneous atypical and epithelioid melanocytic lesions, clear cell renal cell carcinoma, and other tum …
BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene whose mutations have recently been reported to increase susceptibility f …
TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma.
Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Piris A, Nazarian RM, Brown RD, Godfrey JT, Winokur D, Walsh J, Mino-Kenudson M, Maheswaran S, Settleman J, Wargo JA, Flaherty KT, Haber DA, Engelman JA. Corcoran RB, et al. Among authors: piris a. Sci Transl Med. 2013 Jul 31;5(196):196ra98. doi: 10.1126/scitranslmed.3005753. Sci Transl Med. 2013. PMID: 23903755 Free PMC article.
Such a change in P-S6 could be readily monitored in real time by serial fine-needle aspiration biopsies, making quantitation of P-S6 a valuable biomarker to guide treatment in BRAF-mutant melanoma....
Such a change in P-S6 could be readily monitored in real time by serial fine-needle aspiration biopsies, making quantitation of P-S6 …
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. Frederick DT, et al. Among authors: piris a. Clin Cancer Res. 2013 Mar 1;19(5):1225-31. doi: 10.1158/1078-0432.CCR-12-1630. Epub 2013 Jan 10. Clin Cancer Res. 2013. PMID: 23307859 Free PMC article.
This was also associated with a decrease in immunosuppressive cytokines [interleukin (IL)-6 and IL-8] and an increase in markers of T-cell cytotoxicity. ...A decrease in melanoma antigen expression and CD8 T-cell infiltrate was noted at time of progression on BRAF i …
This was also associated with a decrease in immunosuppressive cytokines [interleukin (IL)-6 and IL-8] and an increase in markers of T …
Lethal melanoma in children: a clinicopathological study of 12 cases.
Prieto-Granada CN, Lezcano C, Scolyer RA, Mihm MC Jr, Piris A. Prieto-Granada CN, et al. Among authors: piris a. Pathology. 2016 Dec;48(7):705-711. doi: 10.1016/j.pathol.2016.08.008. Epub 2016 Oct 27. Pathology. 2016. PMID: 27956274
Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors.
Hung T, Piris A, Lobo A, Mihm MC Jr, Sober AJ, Tsao H, Tanabe KK, Duncan LM. Hung T, et al. Among authors: piris a. Hum Pathol. 2013 Jan;44(1):87-94. doi: 10.1016/j.humpath.2012.04.019. Epub 2012 Aug 30. Hum Pathol. 2013. PMID: 22939951
In the past decade, sentinel lymph node mapping has been advocated as a diagnostic test in this setting to discriminate melanoma from benign tumors. ...Sentinel lymph node biopsy may not be a reliable prognostic discriminatory test in patients with atypical Spitz tu …
In the past decade, sentinel lymph node mapping has been advocated as a diagnostic test in this setting to discriminate melanoma from …
Melanoma staging: where are we now?
Piris A, Lobo AC, Duncan LM. Piris A, et al. Dermatol Clin. 2012 Oct;30(4):581-92, v. doi: 10.1016/j.det.2012.06.001. Epub 2012 Jul 31. Dermatol Clin. 2012. PMID: 23021047 Review.
The current schema was based on the largest melanoma patient cohort analyzed to date and is the result of a multivariate analysis of 30,946 patients with stages I, II, and III melanoma and 7972 patients with stage IV melanoma. ...
The current schema was based on the largest melanoma patient cohort analyzed to date and is the result of a multivariate analysis of …
Case records of the Massachusetts General Hospital. Case 30-2010. A 15-year-old boy with a recurrent skin lesion.
Tsao H, Tanabe KK, Lawrence DP, Piris A. Tsao H, et al. Among authors: piris a. N Engl J Med. 2010 Sep 30;363(14):1352-60. doi: 10.1056/NEJMcpc1003889. N Engl J Med. 2010. PMID: 20879885 No abstract available.
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