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Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses.
Sirci F, Napolitano F, Pisonero-Vaquero S, Carrella D, Medina DL, di Bernardo D. Sirci F, et al. Among authors: Pisonero-Vaquero S. NPJ Syst Biol Appl. 2017 Aug 25;3:23. doi: 10.1038/s41540-017-0022-3. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28861278 Free PMC article.
gene2drug: a computational tool for pathway-based rational drug repositioning.
Napolitano F, Carrella D, Mandriani B, Pisonero-Vaquero S, Sirci F, Medina DL, Brunetti-Pierri N, di Bernardo D. Napolitano F, et al. Among authors: Pisonero-Vaquero S. Bioinformatics. 2018 May 1;34(9):1498-1505. doi: 10.1093/bioinformatics/btx800. Bioinformatics. 2018. PMID: 29236977
Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease.
Pisonero-Vaquero S, Martínez-Ferreras Á, García-Mediavilla MV, Martínez-Flórez S, Fernández A, Benet M, Olcoz JL, Jover R, González-Gallego J, Sánchez-Campos S. Pisonero-Vaquero S, et al. Mol Nutr Food Res. 2015 May;59(5):879-93. doi: 10.1002/mnfr.201400913. Epub 2015 Apr 2. Mol Nutr Food Res. 2015. PMID: 25712622
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.
Porras D, Nistal E, Martínez-Flórez S, Pisonero-Vaquero S, Olcoz JL, Jover R, González-Gallego J, García-Mediavilla MV, Sánchez-Campos S. Porras D, et al. Among authors: Pisonero-Vaquero S. Free Radic Biol Med. 2017 Jan;102:188-202. doi: 10.1016/j.freeradbiomed.2016.11.037. Epub 2016 Nov 25. Free Radic Biol Med. 2017. PMID: 27890642
Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy.
Pisonero-Vaquero S, González-Gallego J, Sánchez-Campos S, García-Mediavilla MV. Pisonero-Vaquero S, et al. Curr Med Chem. 2015;22(25):2991-3012. doi: 10.2174/0929867322666150805094940. Curr Med Chem. 2015. PMID: 26242257 Review.
Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease.
Benet M, Guzmán C, Pisonero-Vaquero S, García-Mediavilla MV, Sánchez-Campos S, Martínez-Chantar ML, Donato MT, Castell JV, Jover R. Benet M, et al. Among authors: Pisonero-Vaquero S. Mol Pharmacol. 2015 Apr;87(4):582-94. doi: 10.1124/mol.114.096313. Epub 2015 Jan 9. Mol Pharmacol. 2015. PMID: 25576488
Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.
Pisonero-Vaquero S, García-Mediavilla MV, Jorquera F, Majano PL, Benet M, Jover R, González-Gallego J, Sánchez-Campos S. Pisonero-Vaquero S, et al. Lab Invest. 2014 Mar;94(3):262-74. doi: 10.1038/labinvest.2013.156. Epub 2014 Feb 3. Lab Invest. 2014. PMID: 24492281 Free article.
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.
Guzmán C, Benet M, Pisonero-Vaquero S, Moya M, García-Mediavilla MV, Martínez-Chantar ML, González-Gallego J, Castell JV, Sánchez-Campos S, Jover R. Guzmán C, et al. Biochim Biophys Acta. 2013 Apr;1831(4):803-18. doi: 10.1016/j.bbalip.2012.12.014. Epub 2013 Jan 12. Biochim Biophys Acta. 2013. PMID: 23318274
Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication.
García-Mediavilla MV, Pisonero-Vaquero S, Lima-Cabello E, Benedicto I, Majano PL, Jorquera F, González-Gallego J, Sánchez-Campos S. García-Mediavilla MV, et al. Lab Invest. 2012 Aug;92(8):1191-202. doi: 10.1038/labinvest.2012.88. Epub 2012 May 28. Lab Invest. 2012. PMID: 22641099
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