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DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation.
Charabati M, Grasmuck C, Ghannam S, Bourbonnière L, Fournier AP, Lécuyer MA, Tastet O, Kebir H, Rébillard RM, Hoornaert C, Gowing E, Larouche S, Fortin O, Pittet C, Filali-Mouhim A, Lahav B, Moumdjian R, Bouthillier A, Girard M, Duquette P, Cayrol R, Peelen E, Quintana FJ, Antel JP, Flügel A, Larochelle C, Arbour N, Zandee S, Prat A. Charabati M, et al. Sci Transl Med. 2022 Jan 5;14(626):eabj0473. doi: 10.1126/scitranslmed.abj0473. Epub 2022 Jan 5. Sci Transl Med. 2022. PMID: 34985970
Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.
Ifergan I, Davidson TS, Kebir H, Xu D, Palacios-Macapagal D, Cann J, Rodgers JM, Hunter ZN, Pittet CL, Beddow S, Jones CA, Prat A, Sleeman MA, Miller SD. Ifergan I, et al. Among authors: pittet cl. J Autoimmun. 2017 Nov;84:1-11. doi: 10.1016/j.jaut.2017.06.005. Epub 2017 Jun 20. J Autoimmun. 2017. PMID: 28641926 Free PMC article.
Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.
Lécuyer MA, Saint-Laurent O, Bourbonnière L, Larouche S, Larochelle C, Michel L, Charabati M, Abadier M, Zandee S, Haghayegh Jahromi N, Gowing E, Pittet C, Lyck R, Engelhardt B, Prat A. Lécuyer MA, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E524-E533. doi: 10.1073/pnas.1614336114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069965 Free PMC article.
Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis.
Kebir H, Carmant L, Fontaine F, Béland K, Bosoi CM, Sanon NT, Alvarez JI, Desgent S, Pittet CL, Hébert D, Langlois MJ, Rébillard RM, Nguyen DK, Cieuta-Walti C, Holmes GL, Goodkin HP, Mytinger JR, Connolly MB, Prat A, Haddad E. Kebir H, et al. Among authors: pittet cl. J Clin Invest. 2018 May 1;128(5):2000-2009. doi: 10.1172/JCI97098. Epub 2018 Apr 9. J Clin Invest. 2018. PMID: 29629902 Free PMC article.