Plé PA - Search Results

1

Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Stokes ES, Thomas AP, Johnstone C, Plé PA, Ogilvie DJ, Dukes M, Wedge SR, Kendrew J, Curwen JO. Hennequin LF, et al. Among authors: ple pa. J Med Chem. 2002 Mar 14;45(6):1300-12. doi: 10.1021/jm011022e. J Med Chem. 2002. PMID: 11881999

2

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors.

Barlaam B, Fennell M, Germain H, Green T, Hennequin L, Morgentin R, Olivier A, Plé P, Vautier M, Costello G. Barlaam B, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5446-9. doi: 10.1016/j.bmcl.2005.08.106. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203139

3

Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.

Plé PA, Green TP, Hennequin LF, Curwen J, Fennell M, Allen J, Lambert-Van Der Brempt C, Costello G. Plé PA, et al. J Med Chem. 2004 Feb 12;47(4):871-87. doi: 10.1021/jm030317k. J Med Chem. 2004. PMID: 14761189

4

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.

Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A, Otterbein L, Plé PA, Warin N, Costello G. Hennequin LF, et al. Among authors: ple pa. J Med Chem. 2006 Nov 2;49(22):6465-88. doi: 10.1021/jm060434q. J Med Chem. 2006. PMID: 17064066

5

Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Lambert-van der Brempt C, Morgentin R, Pasquet G, Taylor S. Plé PA, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3050-5. doi: 10.1016/j.bmcl.2012.03.074. Epub 2012 Mar 28. Bioorg Med Chem Lett. 2012. PMID: 22497760

6

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Thomas AP, Johnstone C, Stokes ES, Plé PA, Lohmann JJ, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO, Kendrew J, Lambert-van der Brempt C. Hennequin LF, et al. Among authors: ple pa. J Med Chem. 1999 Dec 30;42(26):5369-89. doi: 10.1021/jm990345w. J Med Chem. 1999. PMID: 10639280

7

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

Barlaam B, Cosulich S, Degorce S, Fitzek M, Giordanetto F, Green S, Inghardt T, Hennequin L, Hancox U, Lambert-van der Brempt C, Morgentin R, Pass S, Plé P, Saleh T, Ward L. Barlaam B, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3928-35. doi: 10.1016/j.bmcl.2014.06.040. Epub 2014 Jun 21. Bioorg Med Chem Lett. 2014. PMID: 24992874

8

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S. Plé PA, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12. Bioorg Med Chem Lett. 2012. PMID: 22153662

9

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.

Green TP, Fennell M, Whittaker R, Curwen J, Jacobs V, Allen J, Logie A, Hargreaves J, Hickinson DM, Wilkinson RW, Elvin P, Boyer B, Carragher N, Plé PA, Bermingham A, Holdgate GA, Ward WH, Hennequin LF, Davies BR, Costello GF. Green TP, et al. Among authors: ple pa. Mol Oncol. 2009 Jun;3(3):248-61. doi: 10.1016/j.molonc.2009.01.002. Epub 2009 Feb 7. Mol Oncol. 2009. PMID: 19393585 Free PMC article.

10

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series.

Barlaam B, Ducray R, Lambert-van der Brempt C, Plé P, Bardelle C, Brooks N, Coleman T, Cross D, Kettle JG, Read J. Barlaam B, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2207-11. doi: 10.1016/j.bmcl.2011.03.009. Bioorg Med Chem Lett. 2011. PMID: 21441027

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