Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

103 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?
Scanzello CR, Plaas A, Crow MK. Scanzello CR, et al. Among authors: plaas a. Curr Opin Rheumatol. 2008 Sep;20(5):565-72. doi: 10.1097/BOR.0b013e32830aba34. Curr Opin Rheumatol. 2008. PMID: 18698179 Review.
Evidence of a similar role for fibronectin is growing. TLRs are expressed and functional in the joint, and many proteases and cytokines that promote cartilage catabolism are dependent on nuclear factor-kappaB, a TLR-activated transcription factor. ...A model …
Evidence of a similar role for fibronectin is growing. TLRs are expressed and functional in the joint, and many proteases and cytokin …
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.
Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Velasco J, et al. Among authors: plaas a. J Biol Chem. 2011 Jul 22;286(29):26016-27. doi: 10.1074/jbc.M110.208694. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566131 Free PMC article.
Here, we describe a novel role for the enzyme in the regulation of TGFβ1 signaling in dermal fibroblasts both in vivo and in vitro. ...Adamts5(-/-) wounds exhibit low expression (relative to wild type) of collagen type I and type III but show a persistently elevated …
Here, we describe a novel role for the enzyme in the regulation of TGFβ1 signaling in dermal fibroblasts both in vivo and in vitro. . …
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis.
Plaas A, Li J, Riesco J, Das R, Sandy JD, Harrison A. Plaas A, et al. Arthritis Res Ther. 2011 Mar 20;13(2):R46. doi: 10.1186/ar3286. Arthritis Res Ther. 2011. PMID: 21418601 Free PMC article.
In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. ...This effect of exogenous HA appears to mimic the protective effects of ablation …
In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes ( …
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.
Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A. Li J, et al. Among authors: plaas a. Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887. Arthritis Res Ther. 2012. PMID: 22721434 Free PMC article.
RESULTS: Injected HA showed a half-life of less than 2 h in the murine knee joint. At the tissue level, HA protected against neovascularization and fibrosis of the meniscus/synovium and maintained articular cartilage integrity in wild-type but not in Cd44 knockout mice. .. …
RESULTS: Injected HA showed a half-life of less than 2 h in the murine knee joint. At the tissue level, HA protected against neovascu …
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A. Li J, et al. Among authors: plaas a. J Orthop Res. 2011 Apr;29(4):516-22. doi: 10.1002/jor.21215. Epub 2010 Oct 26. J Orthop Res. 2011. PMID: 21337391
The cartilage protection provided by ADAMTS5 ablation in the mouse does not result from prevention of aggrecanase activity per se, but it appears to be due to a blockade of joint tissue fibrosis and a concomitant increase in cartilage aggrecan content....
The cartilage protection provided by ADAMTS5 ablation in the mouse does not result from prevention of aggrecanase activity per se, but it ap …
The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis.
Plaas A, Velasco J, Gorski DJ, Li J, Cole A, Christopherson K, Sandy JD. Plaas A, et al. Osteoarthritis Cartilage. 2011 Sep;19(9):1081-90. doi: 10.1016/j.joca.2011.05.003. Epub 2011 May 17. Osteoarthritis Cartilage. 2011. PMID: 21624477 Review.
Lastly, emerging data on a central role for A-Disintegrin-And-Metalloproteinase-with-Thrombospondin-like-Sequences-5 (ADAMTS5) activity in modulating TGFβ1 signaling through activin receptor-like kinase 1 (ALK1) and activin receptor-like kinase 5 (ALK5) pathways is …
Lastly, emerging data on a central role for A-Disintegrin-And-Metalloproteinase-with-Thrombospondin-like-Sequences-5 (ADAMTS5) …
Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis.
Sandy JD, Chan DD, Trevino RL, Wimmer MA, Plaas A. Sandy JD, et al. Among authors: plaas a. Osteoarthritis Cartilage. 2015 Nov;23(11):1939-45. doi: 10.1016/j.joca.2015.03.027. Osteoarthritis Cartilage. 2015. PMID: 26521740 Free PMC article. Review.
A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of cartilage from human osteoarthritis (OA) joints. ...Secondly, due to the number and breadth of studies on IL-1β in this area, a major f
A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of ca
Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.
Chan DD, Xiao WF, Li J, de la Motte CA, Sandy JD, Plaas A. Chan DD, et al. Among authors: plaas a. Osteoarthritis Cartilage. 2015 Nov;23(11):1879-89. doi: 10.1016/j.joca.2015.06.021. Osteoarthritis Cartilage. 2015. PMID: 26521733 Free PMC article.
DESIGN: Femoral groove cartilage of WT and Has1(-/-) mice was debrided to generate a non-bleeding wound. Macroscopic imaging, histology, and gene expression were used to evaluate naïve, sham-operated, and injured joints. ...Notably, Has1 ablation does not alter gross HA co …
DESIGN: Femoral groove cartilage of WT and Has1(-/-) mice was debrided to generate a non-bleeding wound. Macroscopic imaging, histolo …
Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury.
Chan DD, Li J, Luo W, Predescu DN, Cole BJ, Plaas A. Chan DD, et al. Among authors: plaas a. J Orthop Res. 2018 Jan;36(1):365-376. doi: 10.1002/jor.23635. Epub 2017 Jul 21. J Orthop Res. 2018. PMID: 28646530 Free PMC article.
Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthas …
Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in …
Recent Scientific Advances Towards the Development of Tendon Healing Strategies.
Sayegh ET, Sandy JD, Virk MS, Romeo AA, Wysocki RW, Galante JO, Trella KJ, Plaas A, Wang VM. Sayegh ET, et al. Among authors: plaas a. Curr Tissue Eng. 2015;4(2):128-143. doi: 10.2174/2211542004666150713190231. Curr Tissue Eng. 2015. PMID: 26753125 Free PMC article.
There exists a range of surgical and non-surgical approaches to the treatment of both acute and chronic tendon injuries. Despite surgical advances in the management of acute tears and increasing treatment options for tendinopathies, strategies frequently are unsuccessful, …
There exists a range of surgical and non-surgical approaches to the treatment of both acute and chronic tendon injuries. Despite surg …
103 results
Jump to page
Feedback