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Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner.
Al-Salman F, Plant N. Al-Salman F, et al. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):7-13. doi: 10.1016/j.taap.2012.05.016. Epub 2012 Jun 1. Toxicol Appl Pharmacol. 2012. PMID: 22664347
Transcriptional regulation of the human pregnane-X receptor.
Gibson GG, Phillips A, Aouabdi S, Plant K, Plant N. Gibson GG, et al. Drug Metab Rev. 2006;38(1-2):31-49. doi: 10.1080/03602530600569810. Drug Metab Rev. 2006. PMID: 16684647 Review.
Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.
Aouabdi S, Gibson G, Plant N. Aouabdi S, et al. Drug Metab Dispos. 2006 Jan;34(1):138-44. doi: 10.1124/dmd.105.006064. Epub 2005 Oct 21. Drug Metab Dispos. 2006. PMID: 16243957
Interaction networks: coordinating responses to xenobiotic exposure.
Plant N. Plant N. Toxicology. 2004 Sep 30;202(1-2):21-32. doi: 10.1016/j.tox.2004.06.028. Toxicology. 2004. PMID: 15331182
Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.
Abdull Razis AF, Konsue N, Dervetzoglou M, Plant KE, Plant N, Ioannides C. Abdull Razis AF, et al. Mol Nutr Food Res. 2012 Mar;56(3):425-34. doi: 10.1002/mnfr.201100548. Epub 2011 Dec 16. Mol Nutr Food Res. 2012. PMID: 22174033
Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung.
Pushparajah DS, Umachandran M, Plant KE, Plant N, Ioannides C. Pushparajah DS, et al. Mutagenesis. 2008 Jul;23(4):299-308. doi: 10.1093/mutage/gen012. Epub 2008 Apr 3. Mutagenesis. 2008. PMID: 18388359
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