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Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
Mercer PF, Woodcock HV, Eley JD, Platé M, Sulikowski MG, Durrenberger PF, Franklin L, Nanthakumar CB, Man Y, Genovese F, McAnulty RJ, Yang S, Maher TM, Nicholson AG, Blanchard AD, Marshall RP, Lukey PT, Chambers RC. Mercer PF, et al. Among authors: plate m. Thorax. 2016 Aug;71(8):701-11. doi: 10.1136/thoraxjnl-2015-207429. Epub 2016 Apr 21. Thorax. 2016. PMID: 27103349 Free PMC article.
Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.
Butler CR, Hynds RE, Crowley C, Gowers KH, Partington L, Hamilton NJ, Carvalho C, Platé M, Samuel ER, Burns AJ, Urbani L, Birchall MA, Lowdell MW, De Coppi P, Janes SM. Butler CR, et al. Among authors: plate m. Biomaterials. 2017 Apr;124:95-105. doi: 10.1016/j.biomaterials.2017.02.001. Epub 2017 Feb 5. Biomaterials. 2017. PMID: 28189871 Free PMC article.
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Fisher A, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC. Woodcock HV, et al. Among authors: plate m. Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8. Nat Commun. 2019. PMID: 30602778 Free PMC article.
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.
Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, Woodcock HV, Redding M, Taylor A, Brunori G, Durrenberger PF, Ronzoni R, Blanchard AD, Mercer PF, Anastasiou D, Chambers RC. Selvarajah B, et al. Among authors: plate m. Sci Signal. 2019 May 21;12(582):eaav3048. doi: 10.1126/scisignal.aav3048. Sci Signal. 2019. PMID: 31113850 Free PMC article.
Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Fisher A, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC. Woodcock HV, et al. Among authors: plate m. Nat Commun. 2020 Sep 11;11(1):4680. doi: 10.1038/s41467-020-18621-3. Nat Commun. 2020. PMID: 32917879 Free PMC article.
61 results