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Targeting glycosylation as a therapeutic approach.
Dwek RA, Butters TD, Platt FM, Zitzmann N. Dwek RA, et al. Among authors: platt fm. Nat Rev Drug Discov. 2002 Jan;1(1):65-75. doi: 10.1038/nrd708. Nat Rev Drug Discov. 2002. PMID: 12119611 Review.
Modulation of cell-surface transferrin receptor by the imino sugar N-butyldeoxynojirimycin.
Platt FM, Karlsson GB, Jacob GS. Platt FM, et al. Eur J Biochem. 1992 Aug 15;208(1):187-93. doi: 10.1111/j.1432-1033.1992.tb17173.x. Eur J Biochem. 1992. PMID: 1387360
N-butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing.
Platt FM, Neises GR, Karlsson GB, Dwek RA, Butters TD. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14. J Biol Chem. 1994. PMID: 7929454
N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
Platt FM, Neises GR, Dwek RA, Butters TD. Platt FM, et al. J Biol Chem. 1994 Mar 18;269(11):8362-5. J Biol Chem. 1994. PMID: 8132559
Effects of the imino sugar N-butyldeoxynojirimycin on the N-glycosylation of recombinant gp120.
Karlsson GB, Butters TD, Dwek RA, Platt FM. Karlsson GB, et al. Among authors: platt fm. J Biol Chem. 1993 Jan 5;268(1):570-6. J Biol Chem. 1993. PMID: 8416962
N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120.
Fischer PB, Karlsson GB, Butters TD, Dwek RA, Platt FM. Fischer PB, et al. Among authors: platt fm. J Virol. 1996 Oct;70(10):7143-52. doi: 10.1128/JVI.70.10.7143-7152.1996. J Virol. 1996. PMID: 8794361 Free PMC article.
N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure.
Fischer PB, Karlsson GB, Dwek RA, Platt FM. Fischer PB, et al. Among authors: platt fm. J Virol. 1996 Oct;70(10):7153-60. doi: 10.1128/JVI.70.10.7153-7160.1996. J Virol. 1996. PMID: 8794362 Free PMC article.
Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin.
Platt FM, Neises GR, Reinkensmeier G, Townsend MJ, Perry VH, Proia RL, Winchester B, Dwek RA, Butters TD. Platt FM, et al. Science. 1997 Apr 18;276(5311):428-31. doi: 10.1126/science.276.5311.428. Science. 1997. PMID: 9103204
Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin.
Platt FM, Reinkensmeier G, Dwek RA, Butters TD. Platt FM, et al. J Biol Chem. 1997 Aug 1;272(31):19365-72. doi: 10.1074/jbc.272.31.19365. J Biol Chem. 1997. PMID: 9235935
The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding.
Petrescu AJ, Butters TD, Reinkensmeier G, Petrescu S, Platt FM, Dwek RA, Wormald MR. Petrescu AJ, et al. Among authors: platt fm. EMBO J. 1997 Jul 16;16(14):4302-10. doi: 10.1093/emboj/16.14.4302. EMBO J. 1997. PMID: 9250674 Free PMC article.
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