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A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ. Tang T, et al. Among authors: platt ka. Nat Biotechnol. 2010 Jul;28(7):749-55. doi: 10.1038/nbt.1644. Epub 2010 Jun 20. Nat Biotechnol. 2010. PMID: 20562862
BACE (beta-secretase) modulates the processing of APLP2 in vivo.
Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD. Pastorino L, et al. Mol Cell Neurosci. 2004 Apr;25(4):642-9. doi: 10.1016/j.mcn.2003.12.013. Mol Cell Neurosci. 2004. PMID: 15080893
Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus.
Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Vallon V, et al. Among authors: platt ka. Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F156-67. doi: 10.1152/ajprenal.00409.2012. Epub 2012 Nov 14. Am J Physiol Renal Physiol. 2013. PMID: 23152292 Free PMC article.
SGLT2 mediates glucose reabsorption in the early proximal tubule.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Vallon V, et al. Among authors: platt ka. J Am Soc Nephrol. 2011 Jan;22(1):104-12. doi: 10.1681/ASN.2010030246. Epub 2010 Jul 8. J Am Soc Nephrol. 2011. PMID: 20616166 Free PMC article.
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