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Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.
Omholt K, Platz A, Ringborg U, Hansson J. Omholt K, et al. Among authors: platz a. Int J Cancer. 2001 Jun 15;92(6):839-42. doi: 10.1002/ijc.1270. Int J Cancer. 2001. PMID: 11351304
One of 31 primary tumors and 1 of 37 metastases, both originating from the same patient, had a TCT to TTT mutation at codon 45, changing serine to phenylalanine. Immunohistochemical analysis revealed membranous localization of beta-catenin in a majority of the sampl …
One of 31 primary tumors and 1 of 37 metastases, both originating from the same patient, had a TCT to TTT mutation at codon 45, chang …
p53 protein expression and TP53 mutations in malignant melanomas of sun-sheltered mucosal membranes versus chronically sun-exposed skin.
Ragnarsson-Olding B, Platz A, Olding L, Ringborg U. Ragnarsson-Olding B, et al. Among authors: platz a. Melanoma Res. 2004 Oct;14(5):395-401. doi: 10.1097/00008390-200410000-00010. Melanoma Res. 2004. PMID: 15457096
A comparison with previously obtained data on TP53 mutations from the same tumours showed closer concordance amongst mucosal than amongst skin tumours. ...
A comparison with previously obtained data on TP53 mutations from the same tumours showed closer concordance amongst mucosal than amo
Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival.
Grafström E, Egyházi S, Ringborg U, Hansson J, Platz A. Grafström E, et al. Among authors: platz a. Clin Cancer Res. 2005 Apr 15;11(8):2991-7. doi: 10.1158/1078-0432.CCR-04-1731. Clin Cancer Res. 2005. PMID: 15837753
Partial or complete biallelic deletions of the INK4 locus have been recognized in a variety of malignant tumors, including malignant melanoma. ...Patients with tumors with diploid INK4 had a median survival of 142 months, whereas those with monoallelic or biallelic …
Partial or complete biallelic deletions of the INK4 locus have been recognized in a variety of malignant tumors, including malignant …
NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.
Edlundh-Rose E, Egyházi S, Omholt K, Månsson-Brahme E, Platz A, Hansson J, Lundeberg J. Edlundh-Rose E, et al. Among authors: platz a. Melanoma Res. 2006 Dec;16(6):471-8. doi: 10.1097/01.cmr.0000232300.22032.86. Melanoma Res. 2006. PMID: 17119447
In addition, tumours with BRAF mutations showed a significantly more frequent moderate to pronounced infiltration of lymphocytes (P=0.013). NRAS mutations were associated with a significantly higher Clark level of invasion (P=0.022) than BRAF mutations. Age at diagn …
In addition, tumours with BRAF mutations showed a significantly more frequent moderate to pronounced infiltration of lymphocytes (P=0 …
Pyrosequencing as an alternative to single-strand conformation polymorphism analysis for detection of N-ras mutations in human melanoma metastases.
Sivertsson A, Platz A, Hansson J, Lundeberg J. Sivertsson A, et al. Among authors: platz a. Clin Chem. 2002 Dec;48(12):2164-70. Clin Chem. 2002. PMID: 12446472
We evaluated pyrosequencing, a simple and rapid method used mainly for single-nucleotide polymorphism analysis, as a possible alternative to single-strand conformation polymorphism (SSCP) analysis and sequencing of N-ras. ...To evaluate the pyrosequencing method on …
We evaluated pyrosequencing, a simple and rapid method used mainly for single-nucleotide polymorphism analysis, as a possible …
Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations.
Eskandarpour M, Hashemi J, Kanter L, Ringborg U, Platz A, Hansson J. Eskandarpour M, et al. Among authors: platz a. J Natl Cancer Inst. 2003 Jun 4;95(11):790-8. doi: 10.1093/jnci/95.11.790. J Natl Cancer Inst. 2003. PMID: 12783933
NRAS codon 61 mutations were also detected in dysplastic nevi and in an in situ melanoma, suggesting a role for such mutations during early melanoma development. CONCLUSIONS: The high frequency of NRAS codon 61 mutations detected in these hereditary melanomas may be the re …
NRAS codon 61 mutations were also detected in dysplastic nevi and in an in situ melanoma, suggesting a role for such mutations during …
Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site.
Platz A, Egyhazi S, Ringborg U, Hansson J. Platz A, et al. Mol Oncol. 2008 Apr;1(4):395-405. doi: 10.1016/j.molonc.2007.12.003. Epub 2007 Dec 28. Mol Oncol. 2008. PMID: 19383313 Free PMC article.
A majority of cutaneous melanomas show activating mutations in the NRAS or BRAF proto-oncogenes, components of the Ras-Raf-Mek-Erk signal transduction pathway. Consistent data demonstrate the early appearance, in a mutually exclusive manner, of these mutations. The
A majority of cutaneous melanomas show activating mutations in the NRAS or BRAF proto-oncogenes, components of the Ras-Raf-Mek-Erk si
Germline CDKN2A mutations are rare in child and adolescent cutaneous melanoma.
Berg P, Wennberg AM, Tuominen R, Sander B, Rozell BL, Platz A, Hansson J. Berg P, et al. Among authors: platz a. Melanoma Res. 2004 Aug;14(4):251-5. doi: 10.1097/01.cmr.0000131014.79262.bf. Melanoma Res. 2004. PMID: 15305154
A medical history including information on self-reported melanoma heredity was obtained, a physical examination was performed by a dermatologist, and the histopathology slides were reviewed. ...This mutation was seen in a patient belonging to a
A medical history including information on self-reported melanoma heredity was obtained, a physical examination was performed
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J. Omholt K, et al. Among authors: platz a. Clin Cancer Res. 2003 Dec 15;9(17):6483-8. Clin Cancer Res. 2003. PMID: 14695152
Previously, we analyzed a large series of paired primary and metastatic melanomas for NRAS codon 61 mutations and showed that they arise early and are preserved during tumor progression. ...Thirty-seven patients had mutations that lead to a Val599Glu change, whereas …
Previously, we analyzed a large series of paired primary and metastatic melanomas for NRAS codon 61 mutations and showed that they ar …
Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression.
Omholt K, Karsberg S, Platz A, Kanter L, Ringborg U, Hansson J. Omholt K, et al. Among authors: platz a. Clin Cancer Res. 2002 Nov;8(11):3468-74. Clin Cancer Res. 2002. PMID: 12429636
From 20 of the mutated primary tumors, a total of 34 metastases were analyzed, and all but one showed the same mutation as the primary tumor from which they originated. ...N-ras codon 61 mutations were associated with a higher Clark level of invasion (P = 0.012) and …
From 20 of the mutated primary tumors, a total of 34 metastases were analyzed, and all but one showed the same mutation as the primar …
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