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Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer.
Patel S, Player MR. Patel S, et al. Expert Opin Investig Drugs. 2008 Dec;17(12):1865-82. doi: 10.1517/13543780802493366. Expert Opin Investig Drugs. 2008. PMID: 19012502 Review.
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.
Calvo RR, Meegalla SK, Parks DJ, Parsons WH, Ballentine SK, Lubin ML, Schneider C, Colburn RW, Flores CM, Player MR. Calvo RR, et al. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1903-7. doi: 10.1016/j.bmcl.2012.01.060. Epub 2012 Jan 28. Bioorg Med Chem Lett. 2012. PMID: 22330635
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
Huang H, Hutta DA, Rinker JM, Hu H, Parsons WH, Schubert C, DesJarlais RL, Crysler CS, Chaikin MA, Donatelli RR, Chen Y, Cheng D, Zhou Z, Yurkow E, Manthey CL, Player MR. Huang H, et al. J Med Chem. 2009 Feb 26;52(4):1081-99. doi: 10.1021/jm801406h. J Med Chem. 2009. PMID: 19193011
Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.
Meegalla SK, Huang H, Illig CR, Parks DJ, Chen J, Lee YK, Wilson KJ, Patel SK, Cheung WS, Lu T, Kirchner T, Askari HB, Geisler J, Patch RJ, Gibbs AC, Rady B, Connelly M, Player MR. Meegalla SK, et al. Among authors: player mr. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4216-22. doi: 10.1016/j.bmcl.2016.07.054. Epub 2016 Jul 25. Bioorg Med Chem Lett. 2016. PMID: 27491708
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.
Illig CR, Manthey CL, Meegalla SK, Wall MJ, Chen J, Wilson KJ, DesJarlais RL, Ballentine SK, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE. Illig CR, et al. Among authors: player mr. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6363-9. doi: 10.1016/j.bmcl.2013.09.061. Epub 2013 Oct 1. Bioorg Med Chem Lett. 2013. PMID: 24138939
Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
Illig CR, Manthey CL, Wall MJ, Meegalla SK, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE. Illig CR, et al. J Med Chem. 2011 Nov 24;54(22):7860-83. doi: 10.1021/jm200900q. Epub 2011 Oct 31. J Med Chem. 2011. PMID: 22039836
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Patch RJ, Searle LL, Kim AJ, De D, Zhu X, Askari HB, O'Neill JC, Abad MC, Rentzeperis D, Liu J, Kemmerer M, Lin L, Kasturi J, Geisler JG, Lenhard JM, Player MR, Gaul MD. Patch RJ, et al. J Med Chem. 2011 Feb 10;54(3):788-808. doi: 10.1021/jm101063h. Epub 2011 Jan 10. J Med Chem. 2011. PMID: 21218783
Bradykinin B1 receptor antagonists as potential therapeutic agents for pain.
Huang H, Player MR. Huang H, et al. J Med Chem. 2010 Aug 12;53(15):5383-99. doi: 10.1021/jm1000776. J Med Chem. 2010. PMID: 20369879 No abstract available.
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