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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2012 1
2013 4
2014 2
2015 7
2016 4
2017 15
2018 24
2019 13
2020 11
2021 10
2022 6
2023 9
2024 8
2025 21
2026 8

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132 results

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Page 1
Plecanatide: First Global Approval.
Al-Salama ZT, Syed YY. Al-Salama ZT, et al. Drugs. 2017 Apr;77(5):593-598. doi: 10.1007/s40265-017-0718-0. Drugs. 2017. PMID: 28255961 Review.
Plecanatide (Trulance(TM)) is an oral guanylate cyclase-C agonist that is being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) …
Plecanatide (Trulance(TM)) is an oral guanylate cyclase-C agonist that is being developed by Synergy Pharmaceuticals for the t …
American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.
Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. Chang L, et al. Gastroenterology. 2023 Jun;164(7):1086-1106. doi: 10.1053/j.gastro.2023.03.214. Gastroenterology. 2023. PMID: 37211380 Free PMC article.
METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline panel that conducted systematic reviews of the following agents: fiber, osmotic laxatives (polyethylene glycol, magnesium oxide, lactulose), sti …
METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline pane …
Plecanatide.
[No authors listed] [No authors listed] 2025 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000995 Free Books & Documents. Review.
Plecanatide is not absorbed from the gastrointestinal tract and the drug and its active metabolite are not measurable in milk following administration of recommended doses to nursing mothers. Plecanatide is not expected to cause any adverse effects in breastfed infa …
Plecanatide is not absorbed from the gastrointestinal tract and the drug and its active metabolite are not measurable in milk followi …
Plecanatide.
[No authors listed] [No authors listed] 2019 Apr 16. LiverTox®: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2019 Apr 16. LiverTox®: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644071 Free Books & Documents. Review.
Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes o …
Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic co …
Efficacy and Safety of Plecanatide in Chinese Patients with Functional Constipation: A Phase III Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Bai T, Xu Z, Zhen Y, Liao A, Wang B, Zhao R, Zhu Y, Dai N, Liu S, Zhao H, Chen X, Huang K, Xu M, Zhou W, Xu B, Ye B, Zou D, Zhang H, Shi R, Zhang J, Ai Y, Fang X, Lin L, Zhang X, Zhang L, Wang J, Jiang Y, Cui J, Zhang M, Ding X, Zhou Z, Yan P, Li X, Jiang B, Liu Y, Ma Y, Yang S, Wang X, Wu Y, Wu J, Chen H, Hou X. Bai T, et al. Drugs. 2025 Aug;85(8):1033-1048. doi: 10.1007/s40265-025-02205-w. Epub 2025 Jun 26. Drugs. 2025. PMID: 40571893 Clinical Trial.
BACKGROUND: Plecanatide is a novel guanylate cyclase-C agonist for the treatment of functional constipation (FC). ...CONCLUSIONS: Plecanatide 3 mg was effective and well tolerated in the treatment of Chinese patients with FC. ...
BACKGROUND: Plecanatide is a novel guanylate cyclase-C agonist for the treatment of functional constipation (FC). ...CONCLUSIONS: …
American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.
Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. Chang L, et al. Am J Gastroenterol. 2023 Jun 1;118(6):936-954. doi: 10.14309/ajg.0000000000002227. Epub 2023 May 19. Am J Gastroenterol. 2023. PMID: 37204227 Free PMC article.
METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline panel that conducted systematic reviews of the following agents: fiber, osmotic laxatives (polyethylene glycol, magnesium oxide, lactulose), sti …
METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline pane …
Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis.
Luthra P, Camilleri M, Burr NE, Quigley EMM, Black CJ, Ford AC. Luthra P, et al. Lancet Gastroenterol Hepatol. 2019 Nov;4(11):831-844. doi: 10.1016/S2468-1253(19)30246-8. Epub 2019 Aug 29. Lancet Gastroenterol Hepatol. 2019. PMID: 31474542 Free article.
METHODS: We searched Medline, Embase, Embase Classic, and the Cochrane Central Register of Controlled Trials for randomised controlled trials published from inception to week 3 June, 2019, to identify randomised controlled trials assessing the efficacy of drugs (osmotic or stimul …
METHODS: We searched Medline, Embase, Embase Classic, and the Cochrane Central Register of Controlled Trials for randomised controlled trial …
AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation.
Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ. Chang L, et al. Gastroenterology. 2022 Jul;163(1):118-136. doi: 10.1053/j.gastro.2022.04.016. Gastroenterology. 2022. PMID: 35738724
The technical review panel prioritized clinical questions and outcomes according to their importance for clinicians and patients and conducted an evidence review of the following agents: tenapanor, plecanatide, linaclotide, tegaserod, lubiprostone, polyethylene glycol laxa …
The technical review panel prioritized clinical questions and outcomes according to their importance for clinicians and patients and conduct …
132 results