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Illuminating the structure and function of Cys-loop receptors.

Pless SA, Lynch JW. Pless SA, et al. Clin Exp Pharmacol Physiol. 2008 Oct;35(10):1137-42. doi: 10.1111/j.1440-1681.2008.04954.x. Epub 2008 May 25. Clin Exp Pharmacol Physiol. 2008. PMID: 18505452 Review.

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Conformational variability of the glycine receptor M2 domain in response to activation by different agonists.

Pless SA, Dibas MI, Lester HA, Lynch JW. Pless SA, et al. J Biol Chem. 2007 Dec 7;282(49):36057-67. doi: 10.1074/jbc.M706468200. Epub 2007 Oct 2. J Biol Chem. 2007. PMID: 17911099

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A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.

Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA. Pless SA, et al. J Neurosci. 2008 Oct 22;28(43):10937-42. doi: 10.1523/JNEUROSCI.2540-08.2008. J Neurosci. 2008. PMID: 18945901 Free PMC article.

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Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits.

Pless SA, Lynch JW. Pless SA, et al. J Neurochem. 2009 Mar;108(6):1585-94. doi: 10.1111/j.1471-4159.2009.05930.x. Epub 2009 Jan 24. J Neurochem. 2009. PMID: 19166513

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Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain.

Pless SA, Lynch JW. Pless SA, et al. J Biol Chem. 2009 Jun 5;284(23):15847-56. doi: 10.1074/jbc.M809343200. Epub 2009 Mar 13. J Biol Chem. 2009. PMID: 19286654 Free PMC article.

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Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.

Pless SA, Lynch JW. Pless SA, et al. J Biol Chem. 2009 Oct 2;284(40):27370-6. doi: 10.1074/jbc.M109.048405. Epub 2009 Jul 30. J Biol Chem. 2009. PMID: 19643731 Free PMC article.

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Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.

Wang Q, Pless SA, Lynch JW. Wang Q, et al. Among authors: pless sa. J Biol Chem. 2010 Dec 17;285(51):40373-86. doi: 10.1074/jbc.M110.161513. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937799 Free PMC article.

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A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.

Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC. Pless SA, et al. Mol Pharmacol. 2011 Apr;79(4):742-8. doi: 10.1124/mol.110.069583. Epub 2011 Jan 25. Mol Pharmacol. 2011. PMID: 21266487 Free PMC article.

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Intermediate state trapping of a voltage sensor.

Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F. Lacroix JJ, et al. Among authors: pless sa. J Gen Physiol. 2012 Dec;140(6):635-52. doi: 10.1085/jgp.201210827. J Gen Physiol. 2012. PMID: 23183699 Free PMC article.

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Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.

Pless SA, Ahern CA. Pless SA, et al. Annu Rev Pharmacol Toxicol. 2013;53:211-29. doi: 10.1146/annurev-pharmtox-011112-140343. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294309 Review.

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