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Page 1
Plipastatin is a shared good by Bacillus subtilis during combating Fusarium spp.
Stannius RO, Kovács ÁT. Stannius RO, et al. FEMS Microbiol Ecol. 2025 Mar 18;101(4):fiaf020. doi: 10.1093/femsec/fiaf020. FEMS Microbiol Ecol. 2025. PMID: 39999857 Free PMC article.
Fusarium species produce multiple antibacterial compounds resulting in dysbiosis of the plant-associated microbiome and inhibition of plant beneficial bacteria like B. subtilis. While plipastatin is expected to be important for survival of B. subtilis, not all isolates car …
Fusarium species produce multiple antibacterial compounds resulting in dysbiosis of the plant-associated microbiome and inhibition of plant …
Construction and description of a constitutive plipastatin mono-producing Bacillus subtilis.
Vahidinasab M, Lilge L, Reinfurt A, Pfannstiel J, Henkel M, Morabbi Heravi K, Hausmann R. Vahidinasab M, et al. Microb Cell Fact. 2020 Nov 10;19(1):205. doi: 10.1186/s12934-020-01468-0. Microb Cell Fact. 2020. PMID: 33167976 Free PMC article.
We also observed that supplementation of ornithine as a precursor for plipastatin formation caused higher production of plipastatin in mono-producer strains, albeit with a modified pattern of plipastatin composition. CONCLUSIONS: This study provides evidence …
We also observed that supplementation of ornithine as a precursor for plipastatin formation caused higher production of plipastati …
Research on the Regulation of Plipastatin Production by the Quorum-Sensing ComQXPA System of Bacillus amyloliquefaciens.
Zhou J, Wu G, Zheng J, Abdalmegeed D, Wang M, Sun S, Sedjoah RA, Shao Y, Sun S, Xin Z. Zhou J, et al. J Agric Food Chem. 2023 Jul 19;71(28):10683-10692. doi: 10.1021/acs.jafc.3c03120. Epub 2023 Jul 10. J Agric Food Chem. 2023. PMID: 37427858
Integrating ComQXPA into plipastatin mono-producing M-24:MtP(srfA) increased the yield of plipastatin to 3850 mg/L, representing the highest yield reported to date. ...Among them, three plipastatins contained two double bonds in the fatty acid side chain, rep …
Integrating ComQXPA into plipastatin mono-producing M-24:MtP(srfA) increased the yield of plipastatin to 3850 mg/L, representi …
Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides.
Gao L, Ma W, Lu Z, Han J, Ma Z, Liu H, Bie X. Gao L, et al. Synth Syst Biotechnol. 2022 Sep 20;7(4):1173-1180. doi: 10.1016/j.synbio.2022.09.001. eCollection 2022 Dec. Synth Syst Biotechnol. 2022. PMID: 36204332 Free PMC article.
However, there are few reports on NRPS subunit recombination of plipastatin at present. In this paper, plipastatin synthase was modified by the forward movement of subunit PPSE and the replacement of the communication-mediating (COM) domain. The results showed that …
However, there are few reports on NRPS subunit recombination of plipastatin at present. In this paper, plipastatin synthase wa …
Plipastatin A1 produced by a marine sediment-derived Bacillus amyloliquefaciens SH-B74 contributes to the control of gray mold disease in tomato.
Ma Z, Hu J. Ma Z, et al. 3 Biotech. 2018 Feb;8(2):125. doi: 10.1007/s13205-018-1144-z. Epub 2018 Feb 13. 3 Biotech. 2018. PMID: 29450115 Free PMC article.
Moreover, data from activity evaluation revealed that plipastatin A1 has excellent in vitro activity on the suppression of the conidia germination of B. cinerea, the causal agent of gray mold disease in tomato. Furthermore, plipastatin A1 can successfully decrease t …
Moreover, data from activity evaluation revealed that plipastatin A1 has excellent in vitro activity on the suppression of the conidi …
An Integrated Pipeline and Overexpression of a Novel Efflux Transporter, YoeA, Significantly Increases Plipastatin Production in Bacillus subtilis.
Wang M, Zheng J, Sun S, Wu Z, Shao Y, Xiang J, Yin C, Sedjoah RCAA, Xin Z. Wang M, et al. Foods. 2024 Jun 6;13(11):1785. doi: 10.3390/foods13111785. Foods. 2024. PMID: 38891014 Free PMC article.
However, the practical application of plipastatin has been significantly hampered by its low yield in wild Bacillus species. Here, the native promoters of both the plipastatin operon and the sfp gene in the mono-producing strain M-24 were replaced by the constitutiv …
However, the practical application of plipastatin has been significantly hampered by its low yield in wild Bacillus species. Here, th …
Plipastatin and surfactin coproduction by Bacillus subtilis pB2-L and their effects on microorganisms.
Gao L, Han J, Liu H, Qu X, Lu Z, Bie X. Gao L, et al. Antonie Van Leeuwenhoek. 2017 Aug;110(8):1007-1018. doi: 10.1007/s10482-017-0874-y. Epub 2017 May 5. Antonie Van Leeuwenhoek. 2017. PMID: 28477175
To convert the lipopeptide non-producer strain Bacillus subtilis pB2 into a plipastatin and surfactin coproducer, a gene expression cassette composed of a constitutive promoter (P43), functional gene sfp, and pleiotropic regulatory gene degQ was integrated into the chromos …
To convert the lipopeptide non-producer strain Bacillus subtilis pB2 into a plipastatin and surfactin coproducer, a gene expression c …
Clone of plipastatin biosynthetic gene cluster by transformation-associated recombination technique and high efficient expression in model organism Bacillus subtilis.
Hu Y, Nan F, Maina SW, Guo J, Wu S, Xin Z. Hu Y, et al. J Biotechnol. 2018 Dec 20;288:1-8. doi: 10.1016/j.jbiotec.2018.10.006. Epub 2018 Oct 19. J Biotechnol. 2018. PMID: 30343036
However, the application of plipastatin has been hampered by low yields in natural strains, while chemical synthesis is not feasible because of its complex chemical structure. In this study, a scarless genetic modification method was applied to construct a heterologous exp …
However, the application of plipastatin has been hampered by low yields in natural strains, while chemical synthesis is not feasible …
Translocation of the thioesterase domain for the redesign of plipastatin synthetase.
Gao L, Liu H, Ma Z, Han J, Lu Z, Dai C, Lv F, Bie X. Gao L, et al. Sci Rep. 2016 Dec 23;6:38467. doi: 10.1038/srep38467. Sci Rep. 2016. PMID: 28009004 Free PMC article.
The carboxyl-terminal thioesterase (TE) domains from NRPSs catalyse cleavage products by hydrolysis or complex macrocyclization. In this study, we modified plipastatin synthetase by moving the intrinsic TE region to the end of the internal thiolation (T) domains, thus gene …
The carboxyl-terminal thioesterase (TE) domains from NRPSs catalyse cleavage products by hydrolysis or complex macrocyclization. In this stu …
Study on the Impact of Glutamate Domain Swapping on Plipastatin Production.
Wang M, Zheng J, Li W, Liu J, Yin C, Xiang J, Shao Y, Wu G, Xin Z. Wang M, et al. ACS Synth Biol. 2025 Dec 19;14(12):4819-4832. doi: 10.1021/acssynbio.5c00594. Epub 2025 Nov 28. ACS Synth Biol. 2025. PMID: 41311297
Cyclic lipopeptides from Bacillus subtilis are potent antimicrobial agents with promising applications in sustainable agriculture and postharvest preservation. While surfactin and plipastatin share glutamic acid as the substrate incorporated by the initiation module, natur …
Cyclic lipopeptides from Bacillus subtilis are potent antimicrobial agents with promising applications in sustainable agriculture and postha …
88 results