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Mitotane has a strong and a durable inducing effect on CYP3A4 activity.
van Erp NP, Guchelaar HJ, Ploeger BA, Romijn JA, Hartigh Jd, Gelderblom H. van Erp NP, et al. Among authors: ploeger ba. Eur J Endocrinol. 2011 Apr;164(4):621-6. doi: 10.1530/EJE-10-0956. Epub 2011 Jan 10. Eur J Endocrinol. 2011. PMID: 21220434 Clinical Trial.
Explaining variability in ciclosporin exposure in adult kidney transplant recipients.
Press RR, Ploeger BA, den Hartigh J, van der Straaten T, van Pelt H, Danhof M, de Fijter H, Guchelaar HJ. Press RR, et al. Among authors: ploeger ba. Eur J Clin Pharmacol. 2010 Jun;66(6):579-90. doi: 10.1007/s00228-010-0810-9. Epub 2010 Mar 31. Eur J Clin Pharmacol. 2010. PMID: 20354687 Free PMC article.
Marginal increase of sunitinib exposure by grapefruit juice.
van Erp NP, Baker SD, Zandvliet AS, Ploeger BA, den Hollander M, Chen Z, den Hartigh J, König-Quartel JM, Guchelaar HJ, Gelderblom H. van Erp NP, et al. Among authors: ploeger ba. Cancer Chemother Pharmacol. 2011 Mar;67(3):695-703. doi: 10.1007/s00280-010-1367-0. Epub 2010 May 29. Cancer Chemother Pharmacol. 2011. PMID: 20512335 Free PMC article. Clinical Trial.
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