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63 results

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Page 1
Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus.
Harunari E, Bando M, Igarashi Y. Harunari E, et al. J Antibiot (Tokyo). 2022 Feb;75(2):86-91. doi: 10.1038/s41429-021-00489-0. Epub 2021 Nov 30. J Antibiot (Tokyo). 2022. PMID: 34848841
A new pluramycin-class polyketide, rausuquinone (1), and its known congener hydramycin (2) were isolated from the culture extract of the deep-sea water-derived Rhodococcus sp. ...
A new pluramycin-class polyketide, rausuquinone (1), and its known congener hydramycin (2) were isolated from the culture extract of …
A relay ring-closing metathesis/Diels-Alder approach to sugar-derived pluramycin-hybrids.
Singh A, Kaliappan KP. Singh A, et al. Org Biomol Chem. 2024 Aug 22;22(33):6727-6741. doi: 10.1039/d4ob01049c. Org Biomol Chem. 2024. PMID: 39078688
Herein, we present a general approach for synthesizing pluramycin hybrids, which are analogous to the pluramycinone carbocyclic skeleton. This method involves a sequence of relay ring-closing enyne metathesis, Diels-Alder and oxidative aromatization reactions to synthesize …
Herein, we present a general approach for synthesizing pluramycin hybrids, which are analogous to the pluramycinone carbocyclic skele …
Rubiflavin G, photorubiflavin G, and photorubiflavin E: Novel pluramycin derivatives from Streptomyces sp. W2061 and their anticancer activity against breast cancer cells.
Lee B, Lee GE, Hwang GJ, Heo KT, Lee JK, Jang JP, Hwang BY, Jang JH, Cho YY, Hong YS. Lee B, et al. J Antibiot (Tokyo). 2023 Oct;76(10):585-591. doi: 10.1038/s41429-023-00643-w. Epub 2023 Jul 6. J Antibiot (Tokyo). 2023. PMID: 37414938
The pluramycin family of antibiotics comprises angucycline compounds derived from actinomycetes that possess anticancer and antibacterial properties. Pluramycins are structurally characterized by two aminoglycosides linked by a carbon-carbon bond next to the gamma-p …
The pluramycin family of antibiotics comprises angucycline compounds derived from actinomycetes that possess anticancer and antibacte …
Structures of pluramycin A and neopluramycin.
Kondo S, Miyamoto M, Naganawa H, Takeuchi T, Umezawa H. Kondo S, et al. J Antibiot (Tokyo). 1977 Dec;30(12):1143-5. doi: 10.7164/antibiotics.30.1143. J Antibiot (Tokyo). 1977. PMID: 599091 Free article. No abstract available.
Gamma-indomycinone, a new pluramycin metabolite from a deep-sea derived actinomycete.
Schumacher RW, Davidson BS, Montenegro DA, Bernan VS. Schumacher RW, et al. J Nat Prod. 1995 Apr;58(4):613-7. doi: 10.1021/np50118a024. J Nat Prod. 1995. PMID: 7623040
A new member of the pluramycin class of antibiotics, gamma-indomycinone [1], has been isolated along with the known compounds rubiflavinone C-1 [2] and beta-indomycinone [3] from the culture broth of a Streptomyces sp. obtained from a deep-sea sediment core. ...
A new member of the pluramycin class of antibiotics, gamma-indomycinone [1], has been isolated along with the known compounds rubifla …
Natural products with γ-pyrone scaffold from Streptomyces.
Magar RT, Sohng JK. Magar RT, et al. Appl Microbiol Biotechnol. 2024 Sep 24;108(1):471. doi: 10.1007/s00253-024-13296-y. Appl Microbiol Biotechnol. 2024. PMID: 39316232 Free PMC article. Review.
For instance, tetrahydroanthra-gamma-pyrone, shellmycin A-D (27-30) possess antibacterial as well as anticancer activities. In addition, the pluramycin family compounds belonging to anthra-gamma-pyrone group also possess cytotoxic activity, for instance, kidamycin (31), ru …
For instance, tetrahydroanthra-gamma-pyrone, shellmycin A-D (27-30) possess antibacterial as well as anticancer activities. In addition, the …
Hydroxylamine-Mediated Anthrapyranone Formation, Solving 5-exo/6-endo Issue toward Synthesis of Pluramycin-Class Antibiotics.
Shimura J, Ando Y, Suzuki K. Shimura J, et al. Org Lett. 2020 Jan 3;22(1):175-179. doi: 10.1021/acs.orglett.9b04127. Epub 2019 Dec 16. Org Lett. 2020. PMID: 31841345
In our synthetic study on pluramycin-class antibiotics, an unexpected issue arose, i.e., unfavorable regioselectivity of 5-exo rather than 6-endo cyclization to form the pyranone ring. ...
In our synthetic study on pluramycin-class antibiotics, an unexpected issue arose, i.e., unfavorable regioselectivity of 5-exo rather …
TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin.
Sun D, Hurley LH. Sun D, et al. Chem Biol. 1995 Jul;2(7):457-69. doi: 10.1016/1074-5521(95)90263-5. Chem Biol. 1995. PMID: 9383448
Pluramycin adducts are detected by the production of DNA strand breakage products upon heating. ...CONCLUSIONS: We propose that the TBP-DNA-pluramycin ternary complex is a 'specific' binding mode in which TBP and pluramycin make compensatory alterations in DN …
Pluramycin adducts are detected by the production of DNA strand breakage products upon heating. ...CONCLUSIONS: We propose that the T …
Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics.
Sun D, Hansen M, Clement JJ, Hurley LH. Sun D, et al. Biochemistry. 1993 Aug 17;32(32):8068-74. doi: 10.1021/bi00083a003. Biochemistry. 1993. PMID: 8347608
Altromycin B belongs to the pluramycin family of antitumor antibiotics, which also includes kidamycin, hedamycin, pluramycin, neopluramycin, DC92-B, and rubiflavin A. ...On the basis of these results, a general mechanism for the interaction of the pluramycin …
Altromycin B belongs to the pluramycin family of antitumor antibiotics, which also includes kidamycin, hedamycin, pluramycin, …
63 results