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20,641 results

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Page 1
Podophyllotoxin derivatives targeting tubulin: An update (2017-2022).
Xu Y, He Z, Chen L, Wang H. Xu Y, et al. Drug Discov Today. 2023 Aug;28(8):103640. doi: 10.1016/j.drudis.2023.103640. Epub 2023 May 24. Drug Discov Today. 2023. PMID: 37236524 Review.
Numerous tubulin-targeted podophyllotoxin congeners have been designed and synthesized to overcome the poor water solubility of podophyllotoxin and improve its pharmaceutical characteristics. Understanding the interaction of tubulin with its downstream signal transd …
Numerous tubulin-targeted podophyllotoxin congeners have been designed and synthesized to overcome the poor water solubility of po
Podophyllotoxin: History, Recent Advances and Future Prospects.
Shah Z, Gohar UF, Jamshed I, Mushtaq A, Mukhtar H, Zia-Ui-Haq M, Toma SI, Manea R, Moga M, Popovici B. Shah Z, et al. Biomolecules. 2021 Apr 19;11(4):603. doi: 10.3390/biom11040603. Biomolecules. 2021. PMID: 33921719 Free PMC article. Review.
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. ...The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This revi
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active co
Podophyllotoxin.
Canel C, Moraes RM, Dayan FE, Ferreira D. Canel C, et al. Phytochemistry. 2000 May;54(2):115-20. doi: 10.1016/s0031-9422(00)00094-7. Phytochemistry. 2000. PMID: 10872202 Review.
P. hexandnum Royle), is a good source of the aryltetralin-type lignan, podophyllotoxin. The latter compound, as well as its congeners and derivatives exhibit pronounced biological activity mainly as strong antiviral agents and as antineoplastic drugs. The podophyllotoxi
P. hexandnum Royle), is a good source of the aryltetralin-type lignan, podophyllotoxin. The latter compound, as well as its congeners …
Advances of podophyllotoxin and its derivatives: Patterns and mechanisms.
Shi RJ, Fan HY, Yu XH, Tang YL, Jiang J, Liang XH. Shi RJ, et al. Biochem Pharmacol. 2022 Jun;200:115039. doi: 10.1016/j.bcp.2022.115039. Epub 2022 Apr 15. Biochem Pharmacol. 2022. PMID: 35436465 Review.
Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyllotoxin derivatives (PPTs) have been synthesized as candidate drugs to improve the pharmacological characteristics of PPT. ...
Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyll
Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy.
Motyka S, Jafernik K, Ekiert H, Sharifi-Rad J, Calina D, Al-Omari B, Szopa A, Cho WC. Motyka S, et al. Biomed Pharmacother. 2023 Feb;158:114145. doi: 10.1016/j.biopha.2022.114145. Epub 2022 Dec 29. Biomed Pharmacother. 2023. PMID: 36586242 Free article. Review.
A secondary metabolite isolated mainly from the roots and rhizomes of Podophyllum species (Berberidaceae) is aryltetralin lignan - podophyllotoxin (PTOX). The purpose of this review is to discuss the therapeutic properties of PTOX as an important anticancer compound of nat …
A secondary metabolite isolated mainly from the roots and rhizomes of Podophyllum species (Berberidaceae) is aryltetralin lignan - podoph
Podophyllotoxin derivatives as an excellent anticancer aspirant for future chemotherapy: A key current imminent needs.
Zhang X, Rakesh KP, Shantharam CS, Manukumar HM, Asiri AM, Marwani HM, Qin HL. Zhang X, et al. Bioorg Med Chem. 2018 Jan 15;26(2):340-355. doi: 10.1016/j.bmc.2017.11.026. Epub 2017 Nov 16. Bioorg Med Chem. 2018. PMID: 29269253 Review.
Podophyllotoxin derivatives have been the centre of attention of extensive chemical amendment and pharmacological investigation in modern decades. ...The present review focuses mainly onnew anticancer drugs from podophyllotoxin analogs, mechanism of action and their
Podophyllotoxin derivatives have been the centre of attention of extensive chemical amendment and pharmacological investigation in mo
Podophyllotoxin derivatives: a patent review (2012 - 2014).
Kamal A, Ali Hussaini SM, Rahim A, Riyaz S. Kamal A, et al. Expert Opin Ther Pat. 2015;25(9):1025-34. doi: 10.1517/13543776.2015.1051727. Epub 2015 Jun 2. Expert Opin Ther Pat. 2015. PMID: 26027947 Review.
INTRODUCTION: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of anticancer agents. ...
INTRODUCTION: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an interesting lead in the development of anticanc …
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Xiao J, Gao M, Sun Z, Diao Q, Wang P, Gao F. Xiao J, et al. Eur J Med Chem. 2020 Dec 15;208:112830. doi: 10.1016/j.ejmech.2020.112830. Epub 2020 Sep 12. Eur J Med Chem. 2020. PMID: 32992133 Review.
Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-sensitive and drug-resistant even multidrug-resistant cancer cells via inhibition of tubulin polymerization. ...Hybridization of podophyllotoxin/epipodophyllotoxin moiety with oth
Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-sensitive and drug-resistant even multidrug-re
From podophyllotoxin glucoside to etoposide.
Stähelin H, von Wartburg A. Stähelin H, et al. Prog Drug Res. 1989;33:169-266. doi: 10.1007/978-3-0348-9146-2_8. Prog Drug Res. 1989. PMID: 2687938 Review. No abstract available.
Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells.
Guo Q, Jiang E. Guo Q, et al. Curr Top Med Chem. 2021;21(19):1712-1724. doi: 10.2174/1568026621666210113163327. Curr Top Med Chem. 2021. PMID: 33441065 Review.
Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several podophyllotoxin deri
Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus posse
20,641 results
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