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Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.
Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. Ottilie S, et al. Among authors: podust lm. ACS Chem Biol. 2017 Feb 17;12(2):422-434. doi: 10.1021/acschembio.6b01037. Epub 2016 Dec 23. ACS Chem Biol. 2017. PMID: 27977118 Free PMC article.
Two approaches to discovering and developing new drugs for Chagas disease.
McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. McKerrow JH, et al. Among authors: podust lm. Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1(0 1):263-9. doi: 10.1590/s0074-02762009000900034. Mem Inst Oswaldo Cruz. 2009. PMID: 19753483 Free PMC article.
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. Doyle PS, et al. Among authors: podust lm. Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385875 Free PMC article.
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.
Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Gunatilleke SS, et al. Among authors: podust lm. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. PLoS Negl Trop Dis. 2012. PMID: 22860142 Free PMC article.
Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Choy JW, et al. Among authors: podust lm. Beilstein J Org Chem. 2013;9:15-25. doi: 10.3762/bjoc.9.3. Epub 2013 Jan 4. Beilstein J Org Chem. 2013. PMID: 23400640 Free PMC article.
91 results