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Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.
Poe M, Bennett CD, Biddison WE, Blake JT, Norton GP, Rodkey JA, Sigal NH, Turner RV, Wu JK, Zweerink HJ. Poe M, et al. J Biol Chem. 1988 Sep 15;263(26):13215-22. J Biol Chem. 1988. PMID: 3047119
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ. Poe M, et al. J Biol Chem. 1991 Jan 5;266(1):98-103. J Biol Chem. 1991. PMID: 1985927
Q31 granzyme B hydrolyzed Na-t-butyloxycarbonyl-L-alanyl-L-alanyl-L-aspartyl (Boc-Ala-Ala-Asp) thiobenzyl ester with a kcat of 11 +/- 5 mol/s/mol enzyme and catalytic efficiency kcat/Km of 76,000 +/- 44,000 M-1 s-1. ...
Q31 granzyme B hydrolyzed Na-t-butyloxycarbonyl-L-alanyl-L-alanyl-L-aspartyl (Boc-Ala-Ala-Asp) thiobenzyl ester with a kcat of 11 +/- 5 mol/ …
The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.
Poe M, Wu JK, Blake JT, Zweerink HJ, Sigal NH. Poe M, et al. Arch Biochem Biophys. 1991 Jan;284(1):215-8. doi: 10.1016/0003-9861(91)90286-r. Arch Biochem Biophys. 1991. PMID: 1989498
The granzyme A was inhibited in a time-dependent manner with kobs/i = 430,000 +/- 80,000 M-1 s-1. Four other FUT-175 analogs were also found to be potent, rapid Q31 granzyme A inhibitors. ...
The granzyme A was inhibited in a time-dependent manner with kobs/i = 430,000 +/- 80,000 M-1 s-1. Four other FUT-175 analogs were als …
Novel renin inhibitors containing the amino acid statine.
Boger J, Lohr NS, Ulm EH, Poe M, Blaine EH, Fanelli GM, Lin TY, Payne LS, Schorn TW, LaMont BI, Vassil TC, Stabilito II, Veber DF, Rich DH, Bopari AS. Boger J, et al. Nature. 1983 May 5-11;303(5912):81-4. doi: 10.1038/303081a0. Nature. 1983. PMID: 6341856
We report here new highly potent (IC50 = 10(-9)-10(-8) M) competitive inhibitors of renin in which statine, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of the pig renin substrate (Fig. 1)....
We report here new highly potent (IC50 = 10(-9)-10(-8) M) competitive inhibitors of renin in which statine, (3S,4S)-4-amino-3-hydroxy …
Interaction of mouse submaxillary gland renin with a statine-containing, subnanomolar, competitive inhibitor.
Poe M, Perlow DS, Boger J. Poe M, et al. J Enzyme Inhib. 1985;1(1):13-23. doi: 10.3109/14756368509031278. J Enzyme Inhib. 1985. PMID: 3916910
The time course of tight binding of 1 to mouse renin appeared to be fast, with kON greater than or equal to 1.3 x 10(6) s-1 M-1. The UV difference spectrum generated upon binding of 1 to mouse renin had two prominent features: a strong, broad band that had a minimum at 242 …
The time course of tight binding of 1 to mouse renin appeared to be fast, with kON greater than or equal to 1.3 x 10(6) s-1 M-1. The …
Mouse submaxillary gland renin. Purification and properties of minor forms, which include several differently processed forms of the major gene product and a second gene product.
Poe M, Bergstrom AR, Wu JK, Bennett CD, Rodkey JA, Hoogsteen K. Poe M, et al. J Biol Chem. 1984 Jul 10;259(13):8358-62. J Biol Chem. 1984. PMID: 6376503
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