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Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.
Pringle M, Poehlsgaard J, Vester B, Long KS. Pringle M, et al. Among authors: poehlsgaard j. Mol Microbiol. 2004 Dec;54(5):1295-306. doi: 10.1111/j.1365-2958.2004.04373.x. Mol Microbiol. 2004. PMID: 15554969 Free article.
The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA.
Kirpekar F, Hansen LH, Rasmussen A, Poehlsgaard J, Vester B. Kirpekar F, et al. Among authors: poehlsgaard j. J Mol Biol. 2005 May 6;348(3):563-73. doi: 10.1016/j.jmb.2005.03.009. J Mol Biol. 2005. PMID: 15826654
Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.
Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Böttger EC, Vester B. Long KS, et al. Among authors: poehlsgaard j. Mol Microbiol. 2009 Mar;71(5):1218-27. doi: 10.1111/j.1365-2958.2009.06596.x. Epub 2009 Jan 16. Mol Microbiol. 2009. PMID: 19154331 Free article.
The bacterial ribosome as a target for antibiotics.
Poehlsgaard J, Douthwaite S. Poehlsgaard J, et al. Nat Rev Microbiol. 2005 Nov;3(11):870-81. doi: 10.1038/nrmicro1265. Nat Rev Microbiol. 2005. PMID: 16261170 Review.
The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.
Pfister P, Jenni S, Poehlsgaard J, Thomas A, Douthwaite S, Ban N, Böttger EC. Pfister P, et al. Among authors: poehlsgaard j. J Mol Biol. 2004 Oct 1;342(5):1569-81. doi: 10.1016/j.jmb.2004.07.095. J Mol Biol. 2004. PMID: 15364582
The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.
Douthwaite S, Crain PF, Liu M, Poehlsgaard J. Douthwaite S, et al. Among authors: poehlsgaard j. J Mol Biol. 2004 Apr 9;337(5):1073-7. doi: 10.1016/j.jmb.2004.02.030. J Mol Biol. 2004. PMID: 15046978
Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.
Novotny GW, Jakobsen L, Andersen NM, Poehlsgaard J, Douthwaite S. Novotny GW, et al. Among authors: poehlsgaard j. Antimicrob Agents Chemother. 2004 Oct;48(10):3677-83. doi: 10.1128/AAC.48.10.3677-3683.2004. Antimicrob Agents Chemother. 2004. PMID: 15388419 Free PMC article.
Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study.
Farrell DJ, Douthwaite S, Morrissey I, Bakker S, Poehlsgaard J, Jakobsen L, Felmingham D. Farrell DJ, et al. Among authors: poehlsgaard j. Antimicrob Agents Chemother. 2003 Jun;47(6):1777-83. doi: 10.1128/aac.47.6.1777-1783.2003. Antimicrob Agents Chemother. 2003. PMID: 12760848 Free PMC article.
Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.
Poehlsgaard J, Andersen NM, Warrass R, Douthwaite S. Poehlsgaard J, et al. ACS Chem Biol. 2012 Aug 17;7(8):1351-5. doi: 10.1021/cb300105p. Epub 2012 May 14. ACS Chem Biol. 2012. PMID: 22563863
The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics.
Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B. Long KS, et al. Among authors: poehlsgaard j. Antimicrob Agents Chemother. 2006 Jul;50(7):2500-5. doi: 10.1128/AAC.00131-06. Antimicrob Agents Chemother. 2006. PMID: 16801432 Free PMC article.
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