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Correlation of susceptibility test results in vitro with response in vivo: ketoconazole therapy in a systemic candidiasis model.
Polak A, Odds FC, Lüdin E, Scholer HJ. Polak A, et al. Chemotherapy. 1985;31(5):395-404. doi: 10.1159/000238365. Chemotherapy. 1985. PMID: 3902391
In a previous study with flucytosine (5-FC) susceptibility of 40 Candida albicans isolates in vitro proved statistically correlated with response in systemic murine candidiasis in vivo, although exceptions occurred with individual isolates. ...The serotype B isolates gener …
In a previous study with flucytosine (5-FC) susceptibility of 40 Candida albicans isolates in vitro proved statistically correlated w …
Combination therapy of experimental candidiasis, cryptococcosis, aspergillosis and wangiellosis in mice.
Polak A. Polak A. Chemotherapy. 1987;33(5):381-95. doi: 10.1159/000238524. Chemotherapy. 1987. PMID: 2822362
The life-prolonging effect of the combinations was compared with the effect of each partner administered alone and with a double dosage. ...The most pronounced synergism occurred in the infection with a 5-FC-resistant strain of Candida albicans. The degree of synerg …
The life-prolonging effect of the combinations was compared with the effect of each partner administered alone and with a double dosa …
Loss of melanin in Wangiella dermatitidis does not result in greater susceptibility to antifungal agents.
Polak A, Dixon DM. Polak A, et al. Antimicrob Agents Chemother. 1989 Sep;33(9):1639-40. doi: 10.1128/aac.33.9.1639. Antimicrob Agents Chemother. 1989. PMID: 2817864 Free PMC article.
Thus, no consistent increase in in vitro antifungal activity was found to be associated with a specific class of drug. Therefore, melanin does not appear to confer protection against some of the more important antifungal agents....
Thus, no consistent increase in in vitro antifungal activity was found to be associated with a specific class of drug. Therefore, mel …
In vitro and in vivo activity of antifungal agents in combination with fleroxacin, a new quinolone.
Polak A. Polak A. Mycoses. 1990 Apr;33(4):173-8. Mycoses. 1990. PMID: 2122247
Fleroxacin has a synergistic effect with ketoconazole (KETO), but this is not observed with itraconazole (ITRA) or fluconazole (FLU). ...Therefore, the effects seen in in vitro tests are most probably not relevant for the clinical use of a combination of fleroxacin …
Fleroxacin has a synergistic effect with ketoconazole (KETO), but this is not observed with itraconazole (ITRA) or fluconazole (FLU). …
Susceptibility to 5-fluorocytosine and prevalence of serotype in 402 Candida albicans isolates from the United States.
Stiller RL, Bennett JE, Scholer HJ, Wall M, Polak A, Stevens DA. Stiller RL, et al. Antimicrob Agents Chemother. 1982 Sep;22(3):482-7. doi: 10.1128/aac.22.3.482. Antimicrob Agents Chemother. 1982. PMID: 6753737 Free PMC article.
Serotypes A and B accounted for 50.7 and 49.3%, respectively, of the 398 isolates typed. Serotype B was less prevalent in group I (26%), but predominated in the more resistant groups, groups II (85%), III (86%), and IV (53%). The common practice of identifying as "resistan …
Serotypes A and B accounted for 50.7 and 49.3%, respectively, of the 398 isolates typed. Serotype B was less prevalent in group I (26 …
Synergism of polyene antibiotics with 5-fluorocytosine.
Polak A. Polak A. Chemotherapy. 1978;24(1):2-16. doi: 10.1159/000237753. Chemotherapy. 1978. PMID: 338264
In these 3 models candicidin and trichomycin exerted a higher synergistic effect than amph. B or nystatin. In vivo (systemic treatment of septicemic candidiasis of the mouse) the combination of 5-FC with amph. ...Only with this combination a complete cure (culturall …
In these 3 models candicidin and trichomycin exerted a higher synergistic effect than amph. B or nystatin. In vivo (systemic treatmen …
Combination therapy of experimental candidiasis, cryptococcosis and aspergillosis in mice.
Polak A, Scholer HJ, Wall M. Polak A, et al. Chemotherapy. 1982;28(6):461-79. doi: 10.1159/000238138. Chemotherapy. 1982. PMID: 6297858
Combination pairs of the major systematic antimycotic drugs, amphotericin B (AmphB), 5-fluorocytosine (5-FC) and ketoconazole (Ktz) were administered to mice with experimental candidiasis, cryptococcosis and aspergillosis at a variety of combination ratios. ...The combinat …
Combination pairs of the major systematic antimycotic drugs, amphotericin B (AmphB), 5-fluorocytosine (5-FC) and ketoconazole (Ktz) were adm …
Comparative histopathology of Dactylaria constricta, Fonsecaea pedrosoi, Wangiella dermatitidis, and Xylohypha bantiana in experimental phaeohyphomycosis of the central nervous system.
Walsh TJ, Dixon DM, Polak A, Salkin IF. Walsh TJ, et al. Mykosen. 1987 May;30(5):215-25. doi: 10.1111/j.1439-0507.1987.tb03970.x. Mykosen. 1987. PMID: 3614262 No abstract available.
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