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123 results
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Arming antibodies for cancer therapy.
Polakis P. Polakis P. Curr Opin Pharmacol. 2005 Aug;5(4):382-7. doi: 10.1016/j.coph.2005.04.008. Curr Opin Pharmacol. 2005. PMID: 15951239 Review.
Drugging Wnt signalling in cancer.
Polakis P. Polakis P. EMBO J. 2012 Jun 13;31(12):2737-46. doi: 10.1038/emboj.2012.126. Epub 2012 May 22. EMBO J. 2012. PMID: 22617421 Free PMC article. Review.
Wnt signaling in cancer.
Polakis P. Polakis P. Cold Spring Harb Perspect Biol. 2012 May 1;4(5):a008052. doi: 10.1101/cshperspect.a008052. Cold Spring Harb Perspect Biol. 2012. PMID: 22438566 Free PMC article. Review.
The many ways of Wnt in cancer.
Polakis P. Polakis P. Curr Opin Genet Dev. 2007 Feb;17(1):45-51. doi: 10.1016/j.gde.2006.12.007. Curr Opin Genet Dev. 2007. PMID: 17208432 Review.
GEPIS--quantitative gene expression profiling in normal and cancer tissues.
Zhang Y, Eberhard DA, Frantz GD, Dowd P, Wu TD, Zhou Y, Watanabe C, Luoh SM, Polakis P, Hillan KJ, Wood WI, Zhang Z. Zhang Y, et al. Among authors: polakis p. Bioinformatics. 2004 Oct 12;20(15):2390-8. doi: 10.1093/bioinformatics/bth256. Epub 2004 Apr 8. Bioinformatics. 2004. PMID: 15073007
Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
Pillow TH, Tien J, Parsons-Reponte KL, Bhakta S, Li H, Staben LR, Li G, Chuh J, Fourie-O'Donohue A, Darwish M, Yip V, Liu L, Leipold DD, Su D, Wu E, Spencer SD, Shen BQ, Xu K, Kozak KR, Raab H, Vandlen R, Lewis Phillips GD, Scheller RH, Polakis P, Sliwkowski MX, Flygare JA, Junutula JR. Pillow TH, et al. Among authors: polakis p. J Med Chem. 2014 Oct 9;57(19):7890-9. doi: 10.1021/jm500552c. Epub 2014 Sep 18. J Med Chem. 2014. PMID: 25191794
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.
Shen BQ, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, Parsons-Reponte KL, Tien J, Yu SF, Mai E, Li D, Tibbitts J, Baudys J, Saad OM, Scales SJ, McDonald PJ, Hass PE, Eigenbrot C, Nguyen T, Solis WA, Fuji RN, Flagella KM, Patel D, Spencer SD, Khawli LA, Ebens A, Wong WL, Vandlen R, Kaur S, Sliwkowski MX, Scheller RH, Polakis P, Junutula JR. Shen BQ, et al. Among authors: polakis p. Nat Biotechnol. 2012 Jan 22;30(2):184-9. doi: 10.1038/nbt.2108. Nat Biotechnol. 2012. PMID: 22267010
Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.
Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, Bhakta S, Nguyen T, Dugger DL, Li G, Mai E, Lewis Phillips GD, Hiraragi H, Fuji RN, Tibbitts J, Vandlen R, Spencer SD, Scheller RH, Polakis P, Sliwkowski MX. Junutula JR, et al. Among authors: polakis p. Clin Cancer Res. 2010 Oct 1;16(19):4769-78. doi: 10.1158/1078-0432.CCR-10-0987. Epub 2010 Aug 30. Clin Cancer Res. 2010. PMID: 20805300
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