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Mutations in the APC gene and their implications for protein structure and function.
Polakis P. Polakis P. Curr Opin Genet Dev. 1995 Feb;5(1):66-71. doi: 10.1016/s0959-437x(95)90055-1. Curr Opin Genet Dev. 1995. PMID: 7749328 Review.
The many ways of Wnt in cancer.
Polakis P. Polakis P. Curr Opin Genet Dev. 2007 Feb;17(1):45-51. doi: 10.1016/j.gde.2006.12.007. Curr Opin Genet Dev. 2007. PMID: 17208432 Review.
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P. Tran H, et al. Among authors: polakis p. J Biol Chem. 2013 Feb 8;288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31. J Biol Chem. 2013. PMID: 23277359 Free PMC article.
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.
Tran H, Polakis P. Tran H, et al. Among authors: polakis p. J Biol Chem. 2012 Aug 17;287(34):28552-63. doi: 10.1074/jbc.M112.387878. Epub 2012 Jul 3. J Biol Chem. 2012. PMID: 22761442 Free PMC article.
Defects in the regulation of beta-catenin in colorectal cancer.
Polakis P, Hart M, Rubinfeld B. Polakis P, et al. Adv Exp Med Biol. 1999;470:23-32. doi: 10.1007/978-1-4615-4149-3_3. Adv Exp Med Biol. 1999. PMID: 10709671 Review.
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.
Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, Polakis P. Hart M, et al. Among authors: polakis p. Curr Biol. 1999 Feb 25;9(4):207-10. doi: 10.1016/s0960-9822(99)80091-8. Curr Biol. 1999. PMID: 10074433
The oncogenic activation of beta-catenin.
Polakis P. Polakis P. Curr Opin Genet Dev. 1999 Feb;9(1):15-21. doi: 10.1016/s0959-437x(99)80003-3. Curr Opin Genet Dev. 1999. PMID: 10072352 Review.
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P. Hart MJ, et al. Among authors: polakis p. Curr Biol. 1998 May 7;8(10):573-81. doi: 10.1016/s0960-9822(98)70226-x. Curr Biol. 1998. PMID: 9601641
Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.
Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P. Porfiri E, et al. Among authors: polakis p. Oncogene. 1997 Dec 4;15(23):2833-9. doi: 10.1038/sj.onc.1201462. Oncogene. 1997. PMID: 9419974
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.
Rubinfeld B, Albert I, Porfiri E, Munemitsu S, Polakis P. Rubinfeld B, et al. Among authors: polakis p. Cancer Res. 1997 Oct 15;57(20):4624-30. Cancer Res. 1997. PMID: 9377578
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