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The adenomatous polyposis coli (APC) tumor suppressor.
Polakis P. Polakis P. Biochim Biophys Acta. 1997 Jun 7;1332(3):F127-47. doi: 10.1016/s0304-419x(97)00008-5. Biochim Biophys Acta. 1997. PMID: 9196022 Review.
The many ways of Wnt in cancer.
Polakis P. Polakis P. Curr Opin Genet Dev. 2007 Feb;17(1):45-51. doi: 10.1016/j.gde.2006.12.007. Curr Opin Genet Dev. 2007. PMID: 17208432 Review.
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P. Tran H, et al. Among authors: polakis p. J Biol Chem. 2013 Feb 8;288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31. J Biol Chem. 2013. PMID: 23277359 Free PMC article.
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M. Lau T, et al. Among authors: polakis p. Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28. Cancer Res. 2013. PMID: 23539443
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.
Tran H, Polakis P. Tran H, et al. Among authors: polakis p. J Biol Chem. 2012 Aug 17;287(34):28552-63. doi: 10.1074/jbc.M112.387878. Epub 2012 Jul 3. J Biol Chem. 2012. PMID: 22761442 Free PMC article.
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
Easwaran V, Song V, Polakis P, Byers S. Easwaran V, et al. Among authors: polakis p. J Biol Chem. 1999 Jun 4;274(23):16641-5. doi: 10.1074/jbc.274.23.16641. J Biol Chem. 1999. PMID: 10347231
Defects in the regulation of beta-catenin in colorectal cancer.
Polakis P, Hart M, Rubinfeld B. Polakis P, et al. Adv Exp Med Biol. 1999;470:23-32. doi: 10.1007/978-1-4615-4149-3_3. Adv Exp Med Biol. 1999. PMID: 10709671 Review.
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.
Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, Polakis P. Hart M, et al. Among authors: polakis p. Curr Biol. 1999 Feb 25;9(4):207-10. doi: 10.1016/s0960-9822(99)80091-8. Curr Biol. 1999. PMID: 10074433
The oncogenic activation of beta-catenin.
Polakis P. Polakis P. Curr Opin Genet Dev. 1999 Feb;9(1):15-21. doi: 10.1016/s0959-437x(99)80003-3. Curr Opin Genet Dev. 1999. PMID: 10072352 Review.
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P. Hart MJ, et al. Among authors: polakis p. Curr Biol. 1998 May 7;8(10):573-81. doi: 10.1016/s0960-9822(98)70226-x. Curr Biol. 1998. PMID: 9601641
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