Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.
Immunity. 2011.
PMID: 21820334
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polarized secretion of lysosomes at the cell synapse couples antigen extraction to processing and presentation
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Polarized Secretion of Lysosomes at the B Cell Synapse couples Antigen Extraction to Processing and Presentation
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Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.
Immunity. 2011 Sep 23;35(3):361-74. doi: 10.1016/j.immuni.2011.07.008. Epub 2011 Aug 4.
Immunity. 2011.
PMID: 21820334
Free article.
Lysosome recruitment and secretion results from the polarization of the microtubule-organizing center (MTOC), which relies on the cell division cycle (Cdc42)-downstream effector, atypical protein kinase C (aPKCzeta). aPKCzeta is phosphorylated upon BCR …
Lysosome recruitment and secretion results from the polarization of the microtubule-organizing center (MTOC), which rel …
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.
J Cell Biol. 2019 Jul 1;218(7):2247-2264. doi: 10.1083/jcb.201811131. Epub 2019 Jun 13.
J Cell Biol. 2019.
PMID: 31197029
Free PMC article.
B lymphocytes capture antigens from the surface of presenting cells by forming an immune synapse. ...B cells silenced for GEF-H1 or Exo70 display defective lysosome secretion, which results in impaired antigen extraction …
B lymphocytes capture antigens from the surface of presenting cells by forming an immune synapse. ...B cells …
Tuning B cell responses to antigens by cell polarity and membrane trafficking.
Mol Immunol. 2018 Sep;101:140-145. doi: 10.1016/j.molimm.2018.06.013. Epub 2018 Jun 20.
Mol Immunol. 2018.
PMID: 29935436
Review.
Such antigens elicit the formation of an immune synapse (IS), where local cytoskeleton rearrangements coupled to mechanical forces and membrane trafficking orchestrate the extraction and processing of antigens in B cells. In this r …
Such antigens elicit the formation of an immune synapse (IS), where local cytoskeleton rearrangements coupled to mechan …
Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
Mol Biol Cell. 2015 Apr 1;26(7):1273-85. doi: 10.1091/mbc.E14-09-1373. Epub 2015 Jan 28.
Mol Biol Cell. 2015.
PMID: 25631815
Free PMC article.
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for presentation to T-lymphocytes. ...Par3 is also required for antigen presentation to T …
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which faci …
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells.
Front Immunol. 2019 Feb 19;10:225. doi: 10.3389/fimmu.2019.00225. eCollection 2019.
Front Immunol. 2019.
PMID: 30873155
Free PMC article.
This process is coupled to actin remodeling at the centrosome and at the immune synapse, which is crucial to promote cell polarity. ...Consequently, lysosome recruitment to the immune synapse, antigen extraction and …
This process is coupled to actin remodeling at the centrosome and at the immune synapse, which is crucial to promote …
Studying Organelle Dynamics in B Cells During Immune Synapse Formation.
J Vis Exp. 2019 Jun 1;(148). doi: 10.3791/59621.
J Vis Exp. 2019.
PMID: 31205311
Initial stages of actin remodeling allow B cells to increase their cell surface and maximize the quantity of antigen-BCR complexes gathered at the synapse. Under certain conditions, when B cells recognize antigens associated to rigid surf …
Initial stages of actin remodeling allow B cells to increase their cell surface and maximize the quantity of antigen-BC …
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