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Your search for Polarized Secretion of Lysosomes at the B Cell Synapse couples Antigen Extraction to Processing and Presentation retrieved no results
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.
Sáez JJ, Diaz J, Ibañez J, Bozo JP, Cabrera Reyes F, Alamo M, Gobert FX, Obino D, Bono MR, Lennon-Duménil AM, Yeaman C, Yuseff MI. Sáez JJ, et al. J Cell Biol. 2019 Jul 1;218(7):2247-2264. doi: 10.1083/jcb.201811131. Epub 2019 Jun 13. J Cell Biol. 2019. PMID: 31197029 Free PMC article.
B lymphocytes capture antigens from the surface of presenting cells by forming an immune synapse. ...B cells silenced for GEF-H1 or Exo70 display defective lysosome secretion, which results in impaired antigen extraction
B lymphocytes capture antigens from the surface of presenting cells by forming an immune synapse. ...B cells
Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.
Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM. Yuseff MI, et al. Immunity. 2011 Sep 23;35(3):361-74. doi: 10.1016/j.immuni.2011.07.008. Epub 2011 Aug 4. Immunity. 2011. PMID: 21820334 Free article.
Lysosome recruitment and secretion results from the polarization of the microtubule-organizing center (MTOC), which relies on the cell division cycle (Cdc42)-downstream effector, atypical protein kinase C (aPKCzeta). aPKCzeta is phosphorylated upon BCR
Lysosome recruitment and secretion results from the polarization of the microtubule-organizing center (MTOC), which rel
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells.
Ibañez-Vega J, Del Valle Batalla F, Saez JJ, Soza A, Yuseff MI. Ibañez-Vega J, et al. Front Immunol. 2019 Feb 19;10:225. doi: 10.3389/fimmu.2019.00225. eCollection 2019. Front Immunol. 2019. PMID: 30873155 Free PMC article.
This process is coupled to actin remodeling at the centrosome and at the immune synapse, which is crucial to promote cell polarity. ...Consequently, lysosome recruitment to the immune synapse, antigen extraction and …
This process is coupled to actin remodeling at the centrosome and at the immune synapse, which is crucial to promote …
Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM. Reversat A, et al. Mol Biol Cell. 2015 Apr 1;26(7):1273-85. doi: 10.1091/mbc.E14-09-1373. Epub 2015 Jan 28. Mol Biol Cell. 2015. PMID: 25631815 Free PMC article.
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for presentation to T-lymphocytes. ...Par3 is also required for antigen presentation to T …
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which faci …
Studying Organelle Dynamics in B Cells During Immune Synapse Formation.
Ibañez-Vega J, Fuentes D, Lagos J, Cancino J, Yuseff MI. Ibañez-Vega J, et al. J Vis Exp. 2019 Jun 1;(148). doi: 10.3791/59621. J Vis Exp. 2019. PMID: 31205311
Initial stages of actin remodeling allow B cells to increase their cell surface and maximize the quantity of antigen-BCR complexes gathered at the synapse. Under certain conditions, when B cells recognize antigens associated to rigid surf …
Initial stages of actin remodeling allow B cells to increase their cell surface and maximize the quantity of antigen-BC …
Tuning B cell responses to antigens by cell polarity and membrane trafficking.
Del Valle Batalla F, Lennon-Dumenil AM, Yuseff MI. Del Valle Batalla F, et al. Mol Immunol. 2018 Sep;101:140-145. doi: 10.1016/j.molimm.2018.06.013. Epub 2018 Jun 20. Mol Immunol. 2018. PMID: 29935436 Review.
Such antigens elicit the formation of an immune synapse (IS), where local cytoskeleton rearrangements coupled to mechanical forces and membrane trafficking orchestrate the extraction and processing of antigens in B cells. In this r …
Such antigens elicit the formation of an immune synapse (IS), where local cytoskeleton rearrangements coupled to mechan …