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Androgen-activating enzymes in the central nervous system.
Poletti A, Martini L. Poletti A, et al. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):117-22. doi: 10.1016/s0960-0760(98)00150-2. J Steroid Biochem Mol Biol. 1999. PMID: 10418985 Review.
In females, progesterone is reduced to dihydroprogesterone, a precursor of allopregnanolone, a natural anxiolytic/anesthetic steroid. ...The 5alpha-R type 2 shows high affinity for the various substrates, a peculiar pH optimum at acidic values and is localize …
In females, progesterone is reduced to dihydroprogesterone, a precursor of allopregnanolone, a natural anxiolytic/anesthetic s …
Androgen-induced neurite outgrowth is mediated by neuritin in motor neurones.
Marron TU, Guerini V, Rusmini P, Sau D, Brevini TA, Martini L, Poletti A. Marron TU, et al. Among authors: poletti a. J Neurochem. 2005 Jan;92(1):10-20. doi: 10.1111/j.1471-4159.2004.02836.x. J Neurochem. 2005. PMID: 15606892
Androgens either activated or repressed several genes; one has been identified as the mouse neuritin, a protein responsible for neurite elongation. ...Therefore, the trophic effects of androgens in motor neurones may be explained by the androgenic regulation of neuritin, …
Androgens either activated or repressed several genes; one has been identified as the mouse neuritin, a protein responsible for neuri …
Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones.
Pozzi P, Bendotti C, Simeoni S, Piccioni F, Guerini V, Marron TU, Martini L, Poletti A. Pozzi P, et al. Among authors: poletti a. J Neuroendocrinol. 2003 Sep;15(9):882-7. doi: 10.1046/j.1365-2826.2003.01074.x. J Neuroendocrinol. 2003. PMID: 12899683
The low affinity-constitutive type 1 isoenzyme is widely distributed in the body; the high affinity-androgen regulated 5-alpha-reductase type 2 is confined to androgen-dependent structures and shows a peculiar pH optimum at acidic values. ...
The low affinity-constitutive type 1 isoenzyme is widely distributed in the body; the high affinity-androgen regulated 5-alpha-reductase typ …
Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line HC11.
Baratta M, Grolli S, Poletti A, Ramoni R, Motta M, Tamanini C. Baratta M, et al. Among authors: poletti a. J Endocrinol. 2000 Oct;167(1):53-60. doi: 10.1677/joe.0.1670053. J Endocrinol. 2000. PMID: 11018752
HC11 cells were transfected with pbetacCAT, a chimeric rat beta-casein gene promoter-chloramphenicol acetyl transferase (CAT) gene construct and CAT ELISA was used to determine gene expression. ...
HC11 cells were transfected with pbetacCAT, a chimeric rat beta-casein gene promoter-chloramphenicol acetyl transferase (CAT) gene co …
5Alpha-reductase type 2 and androgen receptor expression in gonadotropin releasing hormone GT1-1 cells.
Poletti A, Rampoldi A, Piccioni F, Volpi S, Simeoni S, Zanisi M, Martini L. Poletti A, et al. J Neuroendocrinol. 2001 Apr;13(4):353-7. doi: 10.1046/j.1365-2826.2001.00635.x. J Neuroendocrinol. 2001. PMID: 11264723
However, the 5alpha-reductase enzymatic reaction showed a peak of activity at a narrow pH around 5.5, the optimum for the 5alpha-reductase type 2. ...The data indicate that GT1-1 cells (i) express a "classical" androgen receptor and (ii) contain the 5alpha-re …
However, the 5alpha-reductase enzymatic reaction showed a peak of activity at a narrow pH around 5.5, the optimum for the 5alp …
Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract.
Simeoni S, Mancini MA, Stenoien DL, Marcelli M, Weigel NL, Zanisi M, Martini L, Poletti A. Simeoni S, et al. Among authors: poletti a. Hum Mol Genet. 2000 Jan 1;9(1):133-44. doi: 10.1093/hmg/9.1.133. Hum Mol Genet. 2000. PMID: 10587588
We have produced a model to study the effects of potentially 'neurotoxic' aggregates in SBMA using immortalized motoneuronal cells (NSC34) transfected with AR containing polyGln repeats of different sizes [(AR.Q(n = 0, 23 or 46)]. ...Cell viability analyses have shown a
We have produced a model to study the effects of potentially 'neurotoxic' aggregates in SBMA using immortalized motoneuronal cells (N …
Characterization of rat 5alpha-reductases type 1 and type 2 expressed in Saccharomyces cerevisiae.
Poletti A, Celotti F, Motta M, Martini L. Poletti A, et al. Biochem J. 1996 Mar 15;314 ( Pt 3)(Pt 3):1047-52. doi: 10.1042/bj3141047. Biochem J. 1996. PMID: 8615757 Free PMC article.
In this study, a convenient and efficient system was developed to overexpress the two isoenzymes in Saccharomyces cerevisiae by using the ubiquitin-fusion expression system. ...The activity of the two isoenzymes produced in yeast was determined in cell lysates at the enzym …
In this study, a convenient and efficient system was developed to overexpress the two isoenzymes in Saccharomyces cerevisiae by using …
Metabolism of steroids in the brain: a new insight into the role of 5alpha-reductase and aromatase in brain differentiation and functions.
Negri-Cesi P, Poletti A, Celotti F. Negri-Cesi P, et al. Among authors: poletti a. J Steroid Biochem Mol Biol. 1996 Aug;58(5-6):455-66. doi: 10.1016/0960-0760(96)00083-0. J Steroid Biochem Mol Biol. 1996. PMID: 8918971 Review. No abstract available.
Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life.
Poletti A, Negri-Cesi P, Rabuffetti M, Colciago A, Celotti F, Martini L. Poletti A, et al. Endocrinology. 1998 Apr;139(4):2171-8. doi: 10.1210/endo.139.4.5866. Endocrinology. 1998. PMID: 9529007
The enzyme 5alpha-reductase plays a key role on several brain functions controlling the formation of anxiolytic/anesthetic steroids derived from progesterone and deoxycorticosterone, the conversion of testosterone to dihydrotestosterone, and the removal of excess of potent …
The enzyme 5alpha-reductase plays a key role on several brain functions controlling the formation of anxiolytic/anesthetic steroids d …
Expression and role of functional glucocorticoid receptors in the human androgen-independent prostate cancer cell line, DU145.
Dondi D, Maggi R, Scaccianoce E, Martini L, Motta M, Poletti A. Dondi D, et al. Among authors: poletti a. J Mol Endocrinol. 2001 Jun;26(3):185-91. doi: 10.1677/jme.0.0260185. J Mol Endocrinol. 2001. PMID: 11357055
The results have shown that Dex stimulates the transcriptional activity of GR in transfected DU145 cells with an EC(50) of 9.65 nM and a maximal induction of sevenfold above basal levels. ...In conclusion, the present data suggest a possible role of corticoids in th …
The results have shown that Dex stimulates the transcriptional activity of GR in transfected DU145 cells with an EC(50) of 9.65 nM and a
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