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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs.
Morrissey DV, Lockridge JA, Shaw L, Blanchard K, Jensen K, Breen W, Hartsough K, Machemer L, Radka S, Jadhav V, Vaish N, Zinnen S, Vargeese C, Bowman K, Shaffer CS, Jeffs LB, Judge A, MacLachlan I, Polisky B. Morrissey DV, et al. Among authors: polisky b. Nat Biotechnol. 2005 Aug;23(8):1002-7. doi: 10.1038/nbt1122. Epub 2005 Jul 24. Nat Biotechnol. 2005. PMID: 16041363 Free article.
Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs.
Vaish N, Chen F, Seth S, Fosnaugh K, Liu Y, Adami R, Brown T, Chen Y, Harvie P, Johns R, Severson G, Granger B, Charmley P, Houston M, Templin MV, Polisky B. Vaish N, et al. Among authors: polisky b. Nucleic Acids Res. 2011 Mar;39(5):1823-32. doi: 10.1093/nar/gkq961. Epub 2010 Nov 2. Nucleic Acids Res. 2011. PMID: 21047800 Free PMC article.
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.
Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. Saberi M, et al. Among authors: polisky b. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1137-46. doi: 10.1152/ajpendo.00158.2009. Epub 2009 Aug 25. Am J Physiol Endocrinol Metab. 2009. PMID: 19706791 Free PMC article.
An amino acid-based amphoteric liposomal delivery system for systemic administration of siRNA.
Adami RC, Seth S, Harvie P, Johns R, Fam R, Fosnaugh K, Zhu T, Farber K, McCutcheon M, Goodman TT, Liu Y, Chen Y, Kwang E, Templin MV, Severson G, Brown T, Vaish N, Chen F, Charmley P, Polisky B, Houston ME Jr. Adami RC, et al. Among authors: polisky b. Mol Ther. 2011 Jun;19(6):1141-51. doi: 10.1038/mt.2011.56. Epub 2011 Apr 19. Mol Ther. 2011. PMID: 21505423 Free PMC article.
RNAi-based therapeutics targeting survivin and PLK1 for treatment of bladder cancer.
Seth S, Matsui Y, Fosnaugh K, Liu Y, Vaish N, Adami R, Harvie P, Johns R, Severson G, Brown T, Takagi A, Bell S, Chen Y, Chen F, Zhu T, Fam R, Maciagiewicz I, Kwang E, McCutcheon M, Farber K, Charmley P, Houston ME Jr, So A, Templin MV, Polisky B. Seth S, et al. Among authors: polisky b. Mol Ther. 2011 May;19(5):928-35. doi: 10.1038/mt.2011.21. Epub 2011 Mar 1. Mol Ther. 2011. PMID: 21364537 Free PMC article.
64 results