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Page 1
Polyglutamine aggregation in Huntington and related diseases.
Polling S, Hill AF, Hatters DM. Polling S, et al. Adv Exp Med Biol. 2012;769:125-40. doi: 10.1007/978-1-4614-5434-2_8. Adv Exp Med Biol. 2012. PMID: 23560308 Review.
Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation.
Polling S, Ormsby AR, Wood RJ, Lee K, Shoubridge C, Hughes JN, Thomas PQ, Griffin MD, Hill AF, Bowden Q, Böcking T, Hatters DM. Polling S, et al. Nat Struct Mol Biol. 2015 Dec;22(12):1008-15. doi: 10.1038/nsmb.3127. Epub 2015 Nov 16. Nat Struct Mol Biol. 2015. PMID: 26571108
Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.
Polling S, Mok YF, Ramdzan YM, Turner BJ, Yerbury JJ, Hill AF, Hatters DM. Polling S, et al. J Biol Chem. 2014 Mar 7;289(10):6669-80. doi: 10.1074/jbc.M113.520189. Epub 2014 Jan 14. J Biol Chem. 2014. PMID: 24425868 Free PMC article.
Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge.
Polling S, Hatters DM, Mok YF. Polling S, et al. Methods Mol Biol. 2013;1017:59-71. doi: 10.1007/978-1-62703-438-8_4. Methods Mol Biol. 2013. PMID: 23719907
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Ramdzan YM, Polling S, Chia CP, Ng IH, Ormsby AR, Croft NP, Purcell AW, Bogoyevitch MA, Ng DC, Gleeson PA, Hatters DM. Ramdzan YM, et al. Among authors: polling s. Nat Methods. 2012 Mar 18;9(5):467-70. doi: 10.1038/nmeth.1930. Nat Methods. 2012. PMID: 22426490
Submembranous recruitment of creatine kinase B supports formation of dynamic actin-based protrusions of macrophages and relies on its C-terminal flexible loop.
Venter G, Polling S, Pluk H, Venselaar H, Wijers M, Willemse M, Fransen JA, Wieringa B. Venter G, et al. Among authors: polling s. Eur J Cell Biol. 2015 Feb;94(2):114-27. doi: 10.1016/j.ejcb.2014.11.002. Epub 2014 Nov 24. Eur J Cell Biol. 2015. PMID: 25538032