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Single ocular injection of a sustained-release anti-VEGF delivers 6months pharmacokinetics and efficacy in a primate laser CNV model.
Adamson P, Wilde T, Dobrzynski E, Sychterz C, Polsky R, Kurali E, Haworth R, Tang CM, Korczynska J, Cook F, Papanicolaou I, Tsikna L, Roberts C, Hughes-Thomas Z, Walford J, Gibson D, Warrack J, Smal J, Verrijk R, Miller PE, Nork TM, Prusakiewicz J, Streit T, Sorden S, Struble C, Christian B, Catchpole IR. Adamson P, et al. J Control Release. 2016 Dec 28;244(Pt A):1-13. doi: 10.1016/j.jconrel.2016.10.026. Epub 2016 Nov 1. J Control Release. 2016. PMID: 27810558 Free PMC article.