Polycystic Ovary Syndrome[Mesh] AND Metformin[Mesh] - Search Results

Year	Number of Results
1996	2
1998	2
1999	3
2000	4
2001	3
2002	10
2003	8
2004	10
2005	5
2006	25
2007	14
2008	28
2009	25
2010	25
2011	18
2012	18
2013	15
2014	19
2015	28
2016	19
2017	23
2018	16
2019	22
2020	27
2021	23
2022	42
2023	46
2024	33
2025	45
2026	7

1

Optimising metformin use in polycystic ovary syndrome (MET-PCOS): study protocol for a double-blind randomised controlled trial.

Hautamäki HM, Savolainen-Peltonen H, Rönö K, Melin J. Hautamäki HM, et al. BMJ Open. 2026 Mar 12;16(3):e115656. doi: 10.1136/bmjopen-2025-115656. BMJ Open. 2026. PMID: 41819580 Free PMC article.

2

Synergistic therapeutic effects of metformin and curcumin on polycystic ovary syndrome via regulation of insulin resistance and oxidative stress in a rat model.

Zheng L, Wu B, Zhang J, Zhang Y, Yang Z, Deng C, Huang C, Lu L. Zheng L, et al. Front Endocrinol (Lausanne). 2026 Feb 16;17:1675883. doi: 10.3389/fendo.2026.1675883. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 41778159 Free PMC article.

3

Beyond glycemic control: molecular mechanisms of metformin in modulating cytokine networks in polycystic ovary syndrome.

Ullah A, Chen Y, Zhang F, Shen B. Ullah A, et al. Front Endocrinol (Lausanne). 2026 Feb 9;17:1749906. doi: 10.3389/fendo.2026.1749906. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 41737049 Free PMC article. Review.

4

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin.

Yan Q, Cai M, Wang N, Wu W, Zhang H, Zhu Y, Luo J, Zhang M, Li J. Yan Q, et al. Pharmacotherapy. 2026 Feb;46(2):e70092. doi: 10.1002/phar.70092. Epub 2025 Dec 16. Pharmacotherapy. 2026. PMID: 41401816 Free PMC article. Clinical Trial.

5

Effects of Ziziphus jujuba, metformin, and myoinositol on pregnancy rates and metabolic parameters in infertile women with PCOS: a randomized controlled trial.

Mashhadi F, Ghaebi NK, Rakhshandeh H, Khadem-Rezaiyan M, Roudi F, Nematy M. Mashhadi F, et al. J Ovarian Res. 2026 Jan 30;19(1):51. doi: 10.1186/s13048-025-01867-0. J Ovarian Res. 2026. PMID: 41618368 Free PMC article. Clinical Trial.

6

Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance.

Liang J, Wang Q, Liu D, Wu L, Qiao X, Wang R, Zhong Y, Bo W, Lai H, Fan P, Huang W. Liang J, et al. Front Endocrinol (Lausanne). 2026 Jan 13;16:1725822. doi: 10.3389/fendo.2025.1725822. eCollection 2025. Front Endocrinol (Lausanne). 2026. PMID: 41607469 Free PMC article. Clinical Trial.

7

Ameliorating effects of bromelain with or without metformin on endocrine-metabolic disturbances in letrozole-induced polycystic ovary syndrome in female rats via targeting SIRT1, insulin resistance, and inflammatory axis.

Arab MS, Tahoon DM, El Saadany AA, Hedya SE. Arab MS, et al. Naunyn Schmiedebergs Arch Pharmacol. 2026 Jan;399(2):2465-2480. doi: 10.1007/s00210-025-04517-w. Epub 2025 Aug 30. Naunyn Schmiedebergs Arch Pharmacol. 2026. PMID: 40884596 Free PMC article.

8

Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls.

Mirjalili SA, Kalantar SM, Montazeri F, Azizi R, Hosseini E, Zare F, Asgharzade S, Ashrafi Dehkordi K. Mirjalili SA, et al. PLoS One. 2025 Dec 18;20(12):e0335280. doi: 10.1371/journal.pone.0335280. eCollection 2025. PLoS One. 2025. PMID: 41411269 Free PMC article.

9

Metformin improves pregnancy outcomes in non-PCOS women with insulin resistance and recurrent implantation failure before frozen embryo transfer.

Peng L, Yang W, Du M, Deng X, Zhang R, Qin D, Bao S. Peng L, et al. Front Endocrinol (Lausanne). 2025 Dec 10;16:1671899. doi: 10.3389/fendo.2025.1671899. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 41450577 Free PMC article.

10

Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial.

Dokras A, Coutifaris C, Remaley AT, Mehta NN, Playford MP, Kunselman AR, Stetter CC, Dodson WC, Legro RS. Dokras A, et al. PLoS Med. 2025 Dec 8;22(12):e1004662. doi: 10.1371/journal.pmed.1004662. eCollection 2025 Dec. PLoS Med. 2025. PMID: 41359669 Free PMC article. Clinical Trial.

11

Effect of Insulin Sensitizers on Glycemic and Lipid Profile in Patients with Polycystic Ovary Syndrome (PCOS).

Stevchevska A, Milenkovic T. Stevchevska A, et al. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2025 Dec 6;46(3):51-62. doi: 10.2478/prilozi-2025-0022. Print 2025 Nov 1. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2025. PMID: 41363914 Free article. Clinical Trial.

12

The effects of chiglitazar and metformin on insulin resistance in women with a normal BMI and polycystic ovary syndrome: a randomized controlled study.

Yang Y, Han Y, Xu J, Gao Y, He B. Yang Y, et al. BMC Endocr Disord. 2025 Dec 2;25(1):283. doi: 10.1186/s12902-025-02082-0. BMC Endocr Disord. 2025. PMID: 41331576 Free PMC article. Clinical Trial.

13

Metformin: Paradigm of therapeutic pleiotropism (1922-2025).

de Leiva Hidalgo A, Morell Brotad F. de Leiva Hidalgo A, et al. Med Clin (Barc). 2025 Dec;165(6):107189. doi: 10.1016/j.medcli.2025.107189. Epub 2025 Oct 8. Med Clin (Barc). 2025. PMID: 41067166 Free article. Review. English, Spanish.

14

Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway.

Li JJ, Wu HL, Lv Y, Qin YM, Qiu XX, Cai XX. Li JJ, et al. Gynecol Endocrinol. 2025 Dec;41(1):2528815. doi: 10.1080/09513590.2025.2528815. Epub 2025 Jul 8. Gynecol Endocrinol. 2025. PMID: 40625103 Free article.

15

Mental state and health-related quality of life in patients with polycystic ovary syndrome under metformin therapy - a prospective study.

Hofmann K, Singer S, Theis S, Dionysopoulou A, Schiestl L, Degirmenci Y, Hasenburg A, Schwab R, Skala C. Hofmann K, et al. J Psychosom Obstet Gynaecol. 2025 Dec;46(1):2516669. doi: 10.1080/0167482X.2025.2516669. Epub 2025 Jun 25. J Psychosom Obstet Gynaecol. 2025. PMID: 40562062 Free article.

16

Preconception and first-trimester metformin on pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Cheshire J, Garg A, Smith P, Devall AJ, Coomarasamy A, Dhillon-Smith RK. Cheshire J, et al. Am J Obstet Gynecol. 2025 Dec;233(6):530-547.e8. doi: 10.1016/j.ajog.2025.05.038. Epub 2025 Jun 3. Am J Obstet Gynecol. 2025. PMID: 40473092 Free article.

17

The impact of combined use of probiotics and metformin on metabolic parameters in patients with polycystic ovary syndrome.

Li X, Peng X. Li X, et al. Gynecol Endocrinol. 2025 Dec;41(1):2504980. doi: 10.1080/09513590.2025.2504980. Epub 2025 May 26. Gynecol Endocrinol. 2025. PMID: 40418166 Free article.

18

Improvement of endocrine and metabolic conditions in patients with polycystic ovary syndrome through acupuncture and its combined therapies: a systematic review and meta-analysis.

Wu T, Liu Y, Kong F, Hu J, Liu Y, Yang J, Chen J. Wu T, et al. Ann Med. 2025 Dec;57(1):2477295. doi: 10.1080/07853890.2025.2477295. Epub 2025 Mar 17. Ann Med. 2025. PMID: 40091529 Free PMC article.

19

Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats.

Long XF, Fang YQ, Li YH, Li JY, Wang XP, Wang XL, Zhang L, Liu Y. Long XF, et al. Front Endocrinol (Lausanne). 2025 Nov 26;16:1599879. doi: 10.3389/fendo.2025.1599879. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 41384017 Free PMC article. Clinical Trial.

20

Comparative effects of empagliflozin and metformin on metabolic dysfunction in polycystic ovary syndrome, a double blinded randomized control feasibility trial.

Sharif H, Arsalan S, Rehman N, Muzammil A, Hatif F, Wasti F, Rehman S, Mohsin N, Nasir R, Omair W. Sharif H, et al. BMC Womens Health. 2025 Nov 19;25(1):565. doi: 10.1186/s12905-025-04091-6. BMC Womens Health. 2025. PMID: 41257673 Free PMC article. Clinical Trial.

21

Combined liraglutide and metformin therapy in overweight or obese women with polycystic ovary syndrome: A systematic review and meta-analysis.

Ling J, Wang T, Huang W, Zhen Y, Zhang M, Fang X, Song W, Du X. Ling J, et al. Diabetes Obes Metab. 2025 Nov;27(11):6139-6153. doi: 10.1111/dom.70028. Epub 2025 Aug 26. Diabetes Obes Metab. 2025. PMID: 40855964 Free PMC article.

22

Metformin Treatment in PCOS Pregnancies Reduces Maternal Infections and Increases the Risk of Allergies and Eczema in the Offspring: Post Hoc Analyses of Two Randomised Controlled Trials and One Follow-Up Study.

Ryssdal M, Skage JE, Jarmund AH, Hanem LGE, Løvvik TS, Giskeødegård GF, Iversen AC, Vanky E. Ryssdal M, et al. BJOG. 2025 Nov;132(12):1823-1832. doi: 10.1111/1471-0528.18320. Epub 2025 Aug 11. BJOG. 2025. PMID: 40785326 Free PMC article. Clinical Trial.

23

Effects of drospirenone and ethinylestradiol tablets (II) combined with metformin on the composition of gut microbiota in polycystic ovary syndrome with insulin resistance.

Liu Y, Wang Q, Han L, Shao X, Wang X, Liu X, Wang J, Luo S, Lu B. Liu Y, et al. Front Endocrinol (Lausanne). 2025 Oct 13;16:1581504. doi: 10.3389/fendo.2025.1581504. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 41158623 Free PMC article.

24

Ovulation induction in anovulatory PCOS women.

Diamanti M, La Marca A. Diamanti M, et al. Minerva Obstet Gynecol. 2025 Oct;77(5):373-384. doi: 10.23736/S2724-606X.24.05633-1. Epub 2025 Mar 6. Minerva Obstet Gynecol. 2025. PMID: 40048252 Free article. Review.

25

Efficacy & safety of sodium-glucose cotransporter-2 inhibitors in polycystic ovary syndrome: A meta-analysis with trial sequential analysis.

Ahsan M, Mallick AK. Ahsan M, et al. Indian J Med Res. 2025 Sep;162(3):313-322. doi: 10.25259/IJMR_497_2025. Indian J Med Res. 2025. PMID: 41296583 Free PMC article.

26

Sustained Metabolic Improvements with Low-Dose Metformin Combined with Oral Contraceptives in Female Adolescents with PCOS: A Single-Center Retrospective Cohort Study.

Vitale SG, Di Michele S, Tassi A, Succu C, Angioni S, Fulghesu AM. Vitale SG, et al. Adv Ther. 2025 Aug;42(8):3762-3773. doi: 10.1007/s12325-025-03251-2. Epub 2025 Jun 6. Adv Ther. 2025. PMID: 40478377 Free PMC article.

27

Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial.

Chen H, Lei X, Yang Z, Xu Y, Liu D, Wang C, Du H. Chen H, et al. Reprod Biol Endocrinol. 2025 Jul 26;23(1):108. doi: 10.1186/s12958-025-01447-3. Reprod Biol Endocrinol. 2025. PMID: 40713699 Free PMC article. Clinical Trial.

28

Placental and cerebral circulation in fetuses of mothers with polycystic ovary syndrome and the effect of Metformin exposure.

Nordtvedt E, Kessler J, Ebbing C, Acharya G, Løvvik TS, Salvesen KÅ, Salvesen Ø, Vanky E, Kahrs BH. Nordtvedt E, et al. BMC Pregnancy Childbirth. 2025 Jul 10;25(1):749. doi: 10.1186/s12884-025-07866-9. BMC Pregnancy Childbirth. 2025. PMID: 40640743 Free PMC article. Clinical Trial.

29

Pluchea dioscoridis extract: A novel therapeutic approach for polycystic ovary syndrome targeting ovarian morphology, dopamine pathways, and neurobehavior in relation to its phytocomponents.

Atta R, Gouda SG, Mohamed MH, Afifi SM, Nassar MI, Farag MA, Elshamy AI, Zayed MA, Alqurashi T, Yousof SM. Atta R, et al. PLoS One. 2025 Jun 26;20(6):e0325439. doi: 10.1371/journal.pone.0325439. eCollection 2025. PLoS One. 2025. PMID: 40569946 Free PMC article.

30

Comparative effects of acupuncture and metformin on insulin sensitivity in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Wang Y, Bao H, Cong J, Qu Q. Wang Y, et al. Front Endocrinol (Lausanne). 2025 Jun 18;16:1553684. doi: 10.3389/fendo.2025.1553684. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 40607225 Free PMC article.

31

Dissociation of plasma oxyntomodulin levels from anthropometric measures and metabolic markers in women with polycystic ovary syndrome.

Damasceno RC, Oliveira FR, Cândido AL, Gomes KB, Bizzi MF, Azevedo RC, Comim FV, Reis FM, Rocha ALL. Damasceno RC, et al. Arch Endocrinol Metab. 2025 Jun 18;69(3):e240451. doi: 10.20945/2359-4292-2024-0451. Arch Endocrinol Metab. 2025. PMID: 40532052 Free PMC article.

32

Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study.

Alzahrani KJ. Alzahrani KJ. Med Sci Monit. 2025 Jun 9;31:e947493. doi: 10.12659/MSM.947493. Med Sci Monit. 2025. PMID: 40485087 Free PMC article.

33

Endothelial Function and Matrix Metalloproteinase 9 (MMP9) in Women with Polycystic Ovary Syndrome (PCOS).

Lambadiari V, Pililis S, Lampsas S, Kountouri A, Thymis J, Pliouta L, Peppa M, Kalantaridou S, Oikonomou E, Siasos G, Ikonomidis I. Lambadiari V, et al. Int J Mol Sci. 2025 Jun 7;26(12):5488. doi: 10.3390/ijms26125488. Int J Mol Sci. 2025. PMID: 40564951 Free PMC article.

34

The safety and efficacy of liraglutide combined with metformin in clinical treatment of polycystic ovary syndrome patients: a meta-analysis.

Huang R, He Y. Huang R, et al. BMC Womens Health. 2025 Jun 6;25(1):282. doi: 10.1186/s12905-025-03787-z. BMC Womens Health. 2025. PMID: 40481408 Free PMC article.

35

Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges.

Saadati S, Mason T, Godini R, Vanky E, Teede H, Mousa A. Saadati S, et al. Diabetes Obes Metab. 2025 Jun;27 Suppl 3(Suppl 3):31-47. doi: 10.1111/dom.16422. Epub 2025 May 6. Diabetes Obes Metab. 2025. PMID: 40329601 Free PMC article. Review.

36

Long-term effects of metformin on offspring health: A review of current evidence and future directions.

Mayadunne T, Saadati S, Asmelash D, Mason T, Vanky E, Teede H, Mousa A. Mayadunne T, et al. Diabetes Obes Metab. 2025 Jun;27 Suppl 3(Suppl 3):48-63. doi: 10.1111/dom.16418. Epub 2025 May 6. Diabetes Obes Metab. 2025. PMID: 40326052 Free PMC article. Review.

37

Single-cell profiling of the human endometrium in polycystic ovary syndrome.

Eriksson G, Li C, Sparovec TG, Dekanski A, Torstensson S, Risal S, Ohlsson C, Hirschberg AL, Petropoulos S, Deng Q, Stener-Victorin E. Eriksson G, et al. Nat Med. 2025 Jun;31(6):1925-1938. doi: 10.1038/s41591-025-03592-z. Epub 2025 Mar 20. Nat Med. 2025. PMID: 40114027 Free PMC article.

38

Investigation of Inflammatory Markers in Patients with Polycystic Ovary Syndrome Receiving and Not Receiving Metformin Treatment.

Bulu A, Onalan E, Yakar B, Bulu G, Onalan Yıldırım S, Uğur K, Dönder E. Bulu A, et al. Medicina (Kaunas). 2025 May 28;61(6):1012. doi: 10.3390/medicina61061012. Medicina (Kaunas). 2025. PMID: 40572700 Free PMC article.

39

Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.

Xie Y, Tian Y, Huang J, Deng W, Li X, Liu Y, Liu H, Gao L, Xie Q, Yu Q. Xie Y, et al. Int J Biol Sci. 2025 May 21;21(8):3505-3526. doi: 10.7150/ijbs.104778. eCollection 2025. Int J Biol Sci. 2025. PMID: 40520024 Free PMC article.

40

Efficacy and safety of GLP-1 receptor agonists on weight management and metabolic parameters in PCOS women: a meta-analysis of randomized controlled trials.

Lin S, Deng Y, Huang J, Li M, Sooranna SR, Qin M, Tan B. Lin S, et al. Sci Rep. 2025 May 13;15(1):16512. doi: 10.1038/s41598-025-99622-4. Sci Rep. 2025. PMID: 40360648 Free PMC article.

41

Ranking polycystic ovarian syndrome (PCOS) drugs using degree-based indices in QSPR models and CRITIC-driven MCDM methods.

Rasheed MW, Mahboob A, Amin L, Hussain A. Rasheed MW, et al. Sci Rep. 2025 May 6;15(1):15733. doi: 10.1038/s41598-025-99508-5. Sci Rep. 2025. PMID: 40325183 Free PMC article.

42

Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome.

Lin L, Shen H, Wang Y. Lin L, et al. PLoS One. 2025 Apr 3;20(4):e0321380. doi: 10.1371/journal.pone.0321380. eCollection 2025. PLoS One. 2025. PMID: 40179096 Free PMC article.

43

Lepidium Sativum Extract Alleviates Reproductive and Developmental Toxicity in Polycystic Ovary Syndrome Induced by Letrozole and High-Fat Diet in Rats.

Moustafa MA, Mohamed AS, Dakrory AI, Abdelaziz MH. Moustafa MA, et al. Reprod Sci. 2025 Apr;32(4):1338-1361. doi: 10.1007/s43032-025-01820-y. Epub 2025 Mar 6. Reprod Sci. 2025. PMID: 40048056 Free PMC article.

44

Adropin ameliorates reproductive dysfunctions in letrozole-induced PCOS mouse.

Maurya S, Tripathi S, Arora T, Singh A. Maurya S, et al. Sci Rep. 2025 Mar 13;15(1):8659. doi: 10.1038/s41598-025-93215-x. Sci Rep. 2025. PMID: 40082514 Free PMC article.

45

Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways.

Xu Y, Ning L, Si Y, Li X, Wang R, Ren Q. Xu Y, et al. Front Endocrinol (Lausanne). 2025 Feb 18;16:1526109. doi: 10.3389/fendo.2025.1526109. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 40041289 Free PMC article.

46

Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.

Viña I, Viña JR, Carranza M, Mariscal G. Viña I, et al. Nutrients. 2025 Jan 14;17(2):284. doi: 10.3390/nu17020284. Nutrients. 2025. PMID: 39861414 Free PMC article.

47

Hydroxychloroquine enhances insulin sensitivity and ameliorates abnormal lipid metabolism in obese women with polycystic ovary syndrome.

Wang R, Qi S, Wang Q, Lang J, Pang C, Wang K. Wang R, et al. BMC Endocr Disord. 2025 Jan 2;25(1):2. doi: 10.1186/s12902-024-01827-7. BMC Endocr Disord. 2025. PMID: 39748269 Free PMC article. Clinical Trial.

48

Effect of 40:1 myo-inositol/D-chiro-inositol treatment on serum asprosin levels in polycystic ovary syndrome: a prospective randomized pilot study.

Ozay OE, Ozay Y, Edebal O, Calcagno M, Ozay AC. Ozay OE, et al. Ginekol Pol. 2025;96(11):925-931. doi: 10.5603/gpl.103763. Epub 2025 Jul 16. Ginekol Pol. 2025. PMID: 40665752 Free article. Clinical Trial.

49

Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes.

Brand KM, Gottwald-Hostalek U, Andag-Silva A. Brand KM, et al. Womens Health (Lond). 2025 Jan-Dec;21:17455057241311759. doi: 10.1177/17455057241311759. Womens Health (Lond). 2025. PMID: 39899277 Free PMC article. Review.

50

Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis.

Lin L, Chen G, Qiao X, Chen Y, Deng H, Xu L. Lin L, et al. J Ovarian Res. 2024 Dec 19;17(1):249. doi: 10.1186/s13048-024-01576-0. J Ovarian Res. 2024. PMID: 39702393 Free PMC article.

51

Correlation between anti-müllerian hormone in polycystic ovarian syndrome with metformin: a systematic review and meta-analysis.

Liu H, Mo L, Tian X, Fan S, Hu J, Zhang L, Yu B. Liu H, et al. Gynecol Endocrinol. 2024 Dec;40(1):2330655. doi: 10.1080/09513590.2024.2330655. Epub 2024 Apr 13. Gynecol Endocrinol. 2024. PMID: 38613449 Free article.

52

Comparative effects of the antioxidant glutathione with metformin and Diane-35 on hormonal, metabolic, and inflammatory indicators in a DHEA-induced PCOS rat model.

Coşar A, Özcan P, Tanoglu FB, Tok OE, Özkara G, Timur HT, Çetin Ç, Neccar D. Coşar A, et al. Gynecol Endocrinol. 2024 Dec;40(1):2302086. doi: 10.1080/09513590.2024.2302086. Epub 2024 Jan 22. Gynecol Endocrinol. 2024. PMID: 38254321 Free article.

53

N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.

Fang YQ, Ding H, Li T, Zhao XJ, Luo D, Liu Y, Li Y. Fang YQ, et al. J Ovarian Res. 2024 Oct 16;17(1):205. doi: 10.1186/s13048-024-01528-8. J Ovarian Res. 2024. PMID: 39415242 Free PMC article. Clinical Trial.

54

The Cardiometabolic Risk in Women with Polycystic Ovarian Syndrome (PCOS): From Pathophysiology to Diagnosis and Treatment.

Pililis S, Lampsas S, Kountouri A, Pliouta L, Korakas E, Livadas S, Thymis J, Peppa M, Kalantaridou S, Oikonomou E, Ikonomidis I, Lambadiari V. Pililis S, et al. Medicina (Kaunas). 2024 Oct 10;60(10):1656. doi: 10.3390/medicina60101656. Medicina (Kaunas). 2024. PMID: 39459443 Free PMC article. Review.

55

Gut Microbiota and Oral Contraceptive Use in Women with Polycystic Ovary Syndrome: A Systematic Review.

Wydra J, Szlendak-Sauer K, Zgliczyńska M, Żeber-Lubecka N, Ciebiera M. Wydra J, et al. Nutrients. 2024 Oct 4;16(19):3382. doi: 10.3390/nu16193382. Nutrients. 2024. PMID: 39408349 Free PMC article.

56

Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy.

Kukaev E, Kirillova E, Tokareva A, Rimskaya E, Starodubtseva N, Chernukha G, Priputnevich T, Frankevich V, Sukhikh G. Kukaev E, et al. Int J Mol Sci. 2024 Oct 2;25(19):10636. doi: 10.3390/ijms251910636. Int J Mol Sci. 2024. PMID: 39408965 Free PMC article.

57

Efficacy of WeChat-Based Digital Intervention Versus Metformin in Women With Polycystic Ovary Syndrome: Randomized Controlled Trial.

Dilimulati D, Shao X, Wang L, Cai M, Zhang Y, Lu J, Wang Y, Liu H, Kuang M, Chen H, Zhang M, Qu S. Dilimulati D, et al. J Med Internet Res. 2024 Oct 2;26:e55883. doi: 10.2196/55883. J Med Internet Res. 2024. PMID: 39357046 Free PMC article. Clinical Trial.

58

Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy.

Sánchez-Garrido MA, Serrano-López V, Ruiz-Pino F, Vázquez MJ, Rodríguez-Martín A, Torres E, Velasco I, Rodríguez AB, Chicano-Gálvez E, Mora-Ortiz M, Ohlsson C, Poutanen M, Pinilla L, Gaytán F, Douros JD, Yang B, Müller TD, DiMarchi RD, Tschöp MH, Finan B, Tena-Sempere M. Sánchez-Garrido MA, et al. Nat Commun. 2024 Oct 1;15(1):8498. doi: 10.1038/s41467-024-52898-y. Nat Commun. 2024. PMID: 39353946 Free PMC article.

59

Metformin-induced eyelid myokymia.

Ahsan M, Nizami DJ. Ahsan M, et al. Indian J Pharmacol. 2024 Sep 1;56(5):358-360. doi: 10.4103/ijp.ijp_284_24. Epub 2024 Dec 16. Indian J Pharmacol. 2024. PMID: 39687960 Free PMC article.

60

GDF-15 levels in patients with polycystic ovary syndrome treated with metformin: a combined clinical and in silico pathway analysis.

Magalhães FMV, Pestana RMC, Ferreira CN, Silva IFO, Candido AL, Oliveira FR, Reis FM, Gomes KB. Magalhães FMV, et al. Arch Endocrinol Metab. 2024 Aug 27;68:e230416. doi: 10.20945/2359-4292-2023-0416. eCollection 2024. Arch Endocrinol Metab. 2024. PMID: 39420932 Free PMC article. Clinical Trial.

61

Effects of Zishen Yutai pills combined with metformin on women with polycystic ovary syndrome undergoing in vitro fertilization.

Zhang Y, Cao S, Liang JX, Hu SH, Guo XF, Chun-Jing S, Ge LN. Zhang Y, et al. Medicine (Baltimore). 2024 Aug 2;103(31):e39030. doi: 10.1097/MD.0000000000039030. Medicine (Baltimore). 2024. PMID: 39093743 Free PMC article.

62

Effects of Metformin on CIMT and FMD in PCOS patients: a systematic review and meta-analysis.

Wang F, Yan Y, Wang D, Fan Q, Yi F, Yang X, Lu J. Wang F, et al. BMC Womens Health. 2024 Jul 26;24(1):426. doi: 10.1186/s12905-024-03275-w. BMC Womens Health. 2024. PMID: 39061005 Free PMC article.

63

Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance.

Hu L, Hong G, Li J, Chen M, Chang CJ, Cheng PJ, Zhang Z, Zhang X, Chen H, Zhuang Y, Li Y. Hu L, et al. J Ovarian Res. 2024 Jul 2;17(1):136. doi: 10.1186/s13048-024-01444-x. J Ovarian Res. 2024. PMID: 38956672 Free PMC article.

64

Childbirth experiences in women with polycystic ovary syndrome: A cohort study.

Husby AE, Simpson MR, Dalbye R, Larsen M, Vanky E, Løvvik TS. Husby AE, et al. Acta Obstet Gynecol Scand. 2024 Jun;103(6):1092-1100. doi: 10.1111/aogs.14800. Epub 2024 Feb 17. Acta Obstet Gynecol Scand. 2024. PMID: 38366810 Free PMC article. Clinical Trial.

65

Maternal thyroid function and offspring birth anthropometrics in women with polycystic ovary syndrome.

Trouva A, Alvarsson M, Calissendorff J, Åsvold BO, Ujvari D, Hirschberg AL, Vanky E. Trouva A, et al. Front Endocrinol (Lausanne). 2024 May 29;15:1388473. doi: 10.3389/fendo.2024.1388473. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38868742 Free PMC article. Clinical Trial.

66

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.

Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L. Garcia-Beltran C, et al. Front Endocrinol (Lausanne). 2024 May 16;15:1325230. doi: 10.3389/fendo.2024.1325230. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38818508 Free PMC article. Clinical Trial.

67

Factors contributing to variability in metformin concentration in polycystic ovary syndrome.

Nikolić VN, Stefanović M, Mitić D, Sunarić S, Jović M, Trajković H, Stanković S, Ignjatović A, Stokanović D. Nikolić VN, et al. Croat Med J. 2024 Apr 30;65(2):138-145. doi: 10.3325/cmj.2024.65.138. Croat Med J. 2024. PMID: 38706239 Free PMC article.

68

Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis.

Su P, Chen C, Pang L, Wu K, Sun Y. Su P, et al. Reprod Biol Endocrinol. 2024 Apr 18;22(1):46. doi: 10.1186/s12958-024-01220-y. Reprod Biol Endocrinol. 2024. PMID: 38637876 Free PMC article.

69

Evaluating the therapeutic potential of moxibustion on polycystic ovary syndrome: a rat model study on gut microbiota and metabolite interaction.

Lin Y, Zeng H, Lin J, Peng Y, Que X, Wang L, Chen L, Bai N. Lin Y, et al. Front Cell Infect Microbiol. 2024 Apr 11;14:1328741. doi: 10.3389/fcimb.2024.1328741. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38665877 Free PMC article.

70

The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin: a 2-year observational study.

Jensterle M, Ferjan S, Janez A. Jensterle M, et al. Front Endocrinol (Lausanne). 2024 Apr 11;15:1366940. doi: 10.3389/fendo.2024.1366940. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38665260 Free PMC article.

71

Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication.

Hu R, Huang Y, Geng Y, Liu Z, Li F, Zhang Z, Ma W, Song K, Dong H, Song Y, Zhang M. Hu R, et al. J Ethnopharmacol. 2024 Apr 6;323:117654. doi: 10.1016/j.jep.2023.117654. Epub 2023 Dec 27. J Ethnopharmacol. 2024. PMID: 38158097 Free article.

72

Antimüllerian hormone level predicts ovulation in women with polycystic ovary syndrome treated with clomiphene and metformin.

Komorowski AS, Hughes L, Sarkar P, Aaby DA, Kumar A, Kalra B, Legro RS, Boots CE. Komorowski AS, et al. Fertil Steril. 2024 Apr;121(4):660-668. doi: 10.1016/j.fertnstert.2023.12.031. Epub 2023 Dec 26. Fertil Steril. 2024. PMID: 38154770 Free PMC article. Clinical Trial.

73

Effect of metformin on anti-mullerian hormone levels in women with polycystic ovarian syndrome: a systematic review and meta-regression analysis of randomized controlled trials with.

Mehdinezhad Roshan M, Sohouli MH, Izze da Silva Magalhães E, Hekmatdoost A. Mehdinezhad Roshan M, et al. BMC Endocr Disord. 2024 Mar 29;24(1):43. doi: 10.1186/s12902-024-01570-z. BMC Endocr Disord. 2024. PMID: 38549135 Free PMC article.

74

Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews.

Nassif DS, Januário BL, Sousa BA, Thabane L, Abbade JF. Nassif DS, et al. BMJ Open. 2024 Mar 25;14(3):e078217. doi: 10.1136/bmjopen-2023-078217. BMJ Open. 2024. PMID: 38531582 Free PMC article.

75

Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis.

Juhász AE, Stubnya MP, Teutsch B, Gede N, Hegyi P, Nyirády P, Bánhidy F, Ács N, Juhász R. Juhász AE, et al. Reprod Health. 2024 Feb 22;21(1):28. doi: 10.1186/s12978-024-01758-5. Reprod Health. 2024. PMID: 38388374 Free PMC article.

76

Metformin versus metformin plus pioglitazone on gonadal and metabolic profiles in normal-weight women with polycystic ovary syndrome: a single-center, open-labeled prospective randomized controlled trial.

Zhao H, Zhang J, Xing C, Cheng X, He B. Zhao H, et al. J Ovarian Res. 2024 Feb 19;17(1):42. doi: 10.1186/s13048-024-01367-7. J Ovarian Res. 2024. PMID: 38374053 Free PMC article. Clinical Trial.

77

Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Melin J, Forslund M, Alesi S, Piltonen T, Romualdi D, Spritzer PM, Tay CT, Pena A, Witchel SF, Mousa A, Teede H. Melin J, et al. J Clin Endocrinol Metab. 2024 Jan 18;109(2):e817-e836. doi: 10.1210/clinem/dgad465. J Clin Endocrinol Metab. 2024. PMID: 37554096 Free PMC article.

78

The effects of green tea tablets and metformin on ovulation and menstrual cycle regularity in women with polycystic ovary syndrome.

Yavangi M, Rabiee S, Sanavi Farimani M, Khansary S, Farhadian M, Ranjbar A, Mahmoudi M, Karimi M, Barati S, Barati Mosleh A, Mohammadpour N. Yavangi M, et al. J Med Life. 2024 Jan;17(1):109-115. doi: 10.25122/jml-2022-0066. J Med Life. 2024. PMID: 38737668 Free PMC article. Clinical Trial.

79

A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.

Bader S, Bhatti R, Mussa B, Abusanana S. Bader S, et al. Womens Health (Lond). 2024 Jan-Dec;20:17455057241234530. doi: 10.1177/17455057241234530. Womens Health (Lond). 2024. PMID: 38444070 Free PMC article.

80

The role of berberine in polycystic ovary syndrome - a summary of knowledge.

Jurgiel J, Graniak A, Opyd P, Zawodny T, Lis M. Jurgiel J, et al. Ginekol Pol. 2024;95(4):276-284. doi: 10.5603/gpl.95138. Epub 2023 Dec 18. Ginekol Pol. 2024. PMID: 38108460 Free article. Review.

81

Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial.

Liao M, Li X, Zhang H, Zhou L, Shi L, Li W, Shen R, Peng G, Zhao H, Shao J, Wang X, Sun Z, Zheng H, Long M. Liao M, et al. Endocrine. 2024 Jan;83(1):227-241. doi: 10.1007/s12020-023-03487-4. Epub 2023 Aug 31. Endocrine. 2024. PMID: 37653215 Free PMC article. Clinical Trial.

82

Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero.

Nilsen GØ, Simpson MR, Hanem LGE, Løvvik TS, Ødegård R, Stokkeland LMT, Andersen MS, Juliusson PB, Vanky E. Nilsen GØ, et al. Acta Obstet Gynecol Scand. 2024 Jan;103(1):176-187. doi: 10.1111/aogs.14637. Epub 2023 Jul 24. Acta Obstet Gynecol Scand. 2024. PMID: 37488743 Free PMC article.

83

Metagenomics study on taxonomic and functional change of gut microbiota in patients with obesity with PCOS treated with exenatide combination with metformin or metformin alone.

Gan J, Chen J, Ma RL, Deng Y, Ding XS, Zhu SY, Sun AJ. Gan J, et al. Gynecol Endocrinol. 2023 Dec;39(1):2219342. doi: 10.1080/09513590.2023.2219342. Gynecol Endocrinol. 2023. PMID: 37290480 Free article.

84

Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.

Rabah HM, Mohamed DA, Mariah RA, Abd El-Khalik SR, Khattab HA, AbuoHashish NA, Abdelsattar AM, Raslan MA, Farghal EE, Eltokhy AK. Rabah HM, et al. Redox Rep. 2023 Dec;28(1):2160569. doi: 10.1080/13510002.2022.2160569. Redox Rep. 2023. PMID: 36661246 Free PMC article.

85

Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials.

Ujvari D, Trouva A, Hirschberg AL, Vanky E. Ujvari D, et al. BMJ Open. 2023 Nov 21;13(11):e073619. doi: 10.1136/bmjopen-2023-073619. BMJ Open. 2023. PMID: 37989369 Free PMC article. Clinical Trial.

86

Comparison of exenatide alone or combined with metformin versus metformin in the treatment of polycystic ovaries: a systematic review and meta-analysis.

Hu Y, Song X, Hamiti S, Ma Y, Yusufu M, Wang X, Zhang K, Guo Y. Hu Y, et al. BMC Endocr Disord. 2023 Nov 16;23(1):250. doi: 10.1186/s12902-023-01497-x. BMC Endocr Disord. 2023. PMID: 37974132 Free PMC article.

87

Effects of GLP1RAs on pregnancy rate and menstrual cyclicity in women with polycystic ovary syndrome: a meta-analysis and systematic review.

Zhou L, Qu H, Yang L, Shou L. Zhou L, et al. BMC Endocr Disord. 2023 Nov 8;23(1):245. doi: 10.1186/s12902-023-01500-5. BMC Endocr Disord. 2023. PMID: 37940910 Free PMC article.

88

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial.

Hamad IN, Kadhim SAA, Fawzi HA, Al-Temimi SM, Mohammad B, Swadi A. Hamad IN, et al. J Med Life. 2023 Nov;16(11):1615-1621. doi: 10.25122/jml-2023-0317. J Med Life. 2023. PMID: 38406771 Free PMC article. Clinical Trial.

89

SGLT-2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat PCOS model.

Mahmoud MM, Rashed LA, Soliman SA, Sayed SM, Kamel O, Kamar SS, Hussien RES. Mahmoud MM, et al. Physiol Rep. 2023 Nov;11(22):e15858. doi: 10.14814/phy2.15858. Physiol Rep. 2023. PMID: 37985173 Free PMC article.

90

Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: A model-based meta-analysis.

Tang Z, Guan J, Mao JH, Han L, Zhang JJ, Chen R, Jiao Z. Tang Z, et al. Eur J Pharm Sci. 2023 Nov 1;190:106577. doi: 10.1016/j.ejps.2023.106577. Epub 2023 Sep 2. Eur J Pharm Sci. 2023. PMID: 37666459 Free article.

91

Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.

Hao SL, Zhang CL, Meng XY. Hao SL, et al. Medicine (Baltimore). 2023 Oct 13;102(41):e35152. doi: 10.1097/MD.0000000000035152. Medicine (Baltimore). 2023. PMID: 37832133 Free PMC article.

92

Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy.

Sciacca L, Bianchi C, Burlina S, Formoso G, Manicardi E, Sculli MA, Resi V. Sciacca L, et al. Acta Diabetol. 2023 Oct;60(10):1421-1437. doi: 10.1007/s00592-023-02137-5. Epub 2023 Jul 4. Acta Diabetol. 2023. PMID: 37401946 Free PMC article. Review.

93

SPIOMET4HEALTH-efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, four-arm, parallel-group, phase II clinical trial.

Garcia-Beltran C, Malpique R, Andersen MS, Bas F, Bassols J, Darendeliler F, Díaz M, Dieris B, Fanelli F, Fröhlich-Reiterer E, Gambineri A, Glintborg D, López-Bermejo A, Mann C, Marin S, Obermayer-Pietsch B, Ødegård R, Ravn P, Reinehr T, Renzulli M, Salvador C, Singer V, Vanky E, Torres JV, Yildiz M, de Zegher F, Ibáñez L. Garcia-Beltran C, et al. Trials. 2023 Sep 15;24(1):589. doi: 10.1186/s13063-023-07593-6. Trials. 2023. PMID: 37715279 Free PMC article.

94

Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin.

Kadhem AH, Gholizadeh A, Khalaj-Kondori M. Kadhem AH, et al. J Int Med Res. 2023 Sep;51(9):3000605231196837. doi: 10.1177/03000605231196837. J Int Med Res. 2023. PMID: 37702549 Free PMC article.

95

Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS.

Ryssdal M, Vanky E, Stokkeland LMT, Jarmund AH, Steinkjer B, Løvvik TS, Madssen TS, Iversen AC, Giskeødegård GF. Ryssdal M, et al. J Clin Endocrinol Metab. 2023 Aug 18;108(9):e743-e753. doi: 10.1210/clinem/dgad145. J Clin Endocrinol Metab. 2023. PMID: 36916886 Free PMC article.

96

Identification of Novel Intronic SNPs in Transporter Genes Associated with Metformin Side Effects.

Schweighofer N, Strasser M, Obermayer A, Trummer O, Sourij H, Sourij C, Obermayer-Pietsch B. Schweighofer N, et al. Genes (Basel). 2023 Aug 11;14(8):1609. doi: 10.3390/genes14081609. Genes (Basel). 2023. PMID: 37628660 Free PMC article.

97

The Effectiveness and Safety of Exenatide Versus Metformin in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials.

Ye ZR, Yan CQ, Liao N, Wen SH. Ye ZR, et al. Reprod Sci. 2023 Aug;30(8):2349-2361. doi: 10.1007/s43032-023-01222-y. Epub 2023 Mar 31. Reprod Sci. 2023. PMID: 37002532 Free PMC article. Review.

98

Interaction between OCT1 and LPIN1 polymorphisms and response to pioglitazone-metformin tablets in patients with polycystic ovary syndrome.

Zeng H, Huang Y, Liu D, Xie T, Chen Z, Huang Q, Zhou X, Lai X, Liu J. Zeng H, et al. Chin Med J (Engl). 2023 Jul 20;136(14):1756-1758. doi: 10.1097/CM9.0000000000002322. Epub 2023 May 26. Chin Med J (Engl). 2023. PMID: 37232475 Free PMC article. No abstract available.

99

Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?

Guarano A, Capozzi A, Cristodoro M, Di Simone N, Lello S. Guarano A, et al. Nutrients. 2023 Jul 19;15(14):3209. doi: 10.3390/nu15143209. Nutrients. 2023. PMID: 37513627 Free PMC article. Review.

100

Statins for women with polycystic ovary syndrome not actively trying to conceive.

Xiong T, Fraison E, Kolibianaki E, Costello MF, Venetis C, Kostova EB. Xiong T, et al. Cochrane Database Syst Rev. 2023 Jul 18;7(7):CD008565. doi: 10.1002/14651858.CD008565.pub3. Cochrane Database Syst Rev. 2023. PMID: 37462232 Free PMC article.

101

Low dose of liraglutide combined with metformin leads to a significant weight loss in Chinese Han women with polycystic ovary syndrome: a retrospective study.

Long X, Liu H, Xiong W, Li W, He H, Fu T, Li X, Chen C, Zhang L, Liu Y. Long X, et al. Gynecol Endocrinol. 2023 Jun 29;39(1):2223648. doi: 10.1080/09513590.2023.2223648. Gynecol Endocrinol. 2023. PMID: 37406658 Free article.

102

The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis.

Zhou Z, Chen H, Chu L, Zou Q, Chen Q, Yang J, Liu Y, Ou X. Zhou Z, et al. J Ovarian Res. 2023 Jun 28;16(1):123. doi: 10.1186/s13048-023-01195-1. J Ovarian Res. 2023. PMID: 37381009 Free PMC article.

103

Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond.

Tosti G, Barberio A, Tartaglione L, Rizzi A, Di Leo M, Viti L, Sirico A, De Carolis S, Pontecorvi A, Lanzone A, Pitocco D. Tosti G, et al. Front Endocrinol (Lausanne). 2023 Jun 20;14:1176623. doi: 10.3389/fendo.2023.1176623. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37409227 Free PMC article. Review.

104

Short-term effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome: a pilot randomized trial.

Wen Q, Fang S, Liang Y, Tian Y, Chen Y, Yuan J, Chen Q. Wen Q, et al. Front Endocrinol (Lausanne). 2023 Jun 6;14:1156521. doi: 10.3389/fendo.2023.1156521. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37347114 Free PMC article. Clinical Trial.

105

Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats.

Farhadi-Azar M, Ghahremani M, Mahboobifard F, Noroozzadeh M, Yaghmaei P, Tehrani FR. Farhadi-Azar M, et al. Biomed J. 2023 Jun;46(3):100538. doi: 10.1016/j.bj.2022.05.003. Epub 2022 May 21. Biomed J. 2023. PMID: 35605922 Free PMC article.

106

Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway.

Zhou LH, Zou H, Hao JY, Huang Y, Zhang JN, Xu XH, Li J. Zhou LH, et al. Aging (Albany NY). 2023 May 25;15(10):4429-4443. doi: 10.18632/aging.204745. Epub 2023 May 25. Aging (Albany NY). 2023. PMID: 37244286 Free PMC article.

107

Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age.

Zhong X, Li Y, Liang W, Hu Q, Zeng A, Ding M, Chen D, Xie M. Zhong X, et al. BMC Womens Health. 2023 May 6;23(1):236. doi: 10.1186/s12905-023-02339-7. BMC Womens Health. 2023. PMID: 37149578 Free PMC article.

108

The role of circulating miRNAs in mechanism of action and prediction of therapeutic responses of metformin in polycystic ovarian syndrome.

Huang CC, Yang PK, Huang YS, Chen SU, Yang YS, Chen MJ. Huang CC, et al. Fertil Steril. 2023 May;119(5):858-868. doi: 10.1016/j.fertnstert.2022.12.045. Epub 2023 Jan 7. Fertil Steril. 2023. PMID: 36627014 Free article.

109

Probiotic vs. placebo and metformin: probiotic dietary intervention in polycystic ovary syndrome - A randomized controlled trial.

Borzan V, Riedl R, Obermayer-Pietsch B. Borzan V, et al. BMC Endocr Disord. 2023 Apr 17;23(1):82. doi: 10.1186/s12902-023-01294-6. BMC Endocr Disord. 2023. PMID: 37062834 Free PMC article. Clinical Trial.

110

The Effect of Metformin and Carbohydrate-Controlled Diet on DNA Methylation and Gene Expression in the Endometrium of Women with Polycystic Ovary Syndrome.

García-Gómez E, Gómez-Viais YI, Cruz-Aranda MM, Martínez-Razo LD, Reyes-Mayoral C, Ibarra-González L, Montoya-Estrada A, Osorio-Caballero M, Perichart-Perera O, Camacho-Arroyo I, Cerbón M, Reyes-Muñoz E, Vázquez-Martínez ER. García-Gómez E, et al. Int J Mol Sci. 2023 Apr 6;24(7):6857. doi: 10.3390/ijms24076857. Int J Mol Sci. 2023. PMID: 37047828 Free PMC article.

111

Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients.

Belani MA, Shah P, Banker M, Gupta SS. Belani MA, et al. J Ovarian Res. 2023 Mar 18;16(1):55. doi: 10.1186/s13048-023-01126-0. J Ovarian Res. 2023. PMID: 36932437 Free PMC article.

112

Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.

Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SM. Ali Fadlalmola H, et al. Pan Afr Med J. 2023 Mar 16;44:134. doi: 10.11604/pamj.2023.44.134.32404. eCollection 2023. Pan Afr Med J. 2023. PMID: 37333786 Free PMC article.

113

The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis.

Peng G, Yan Z, Liu Y, Li J, Ma J, Tong N, Wang Y. Peng G, et al. Reprod Biol Endocrinol. 2023 Mar 3;21(1):24. doi: 10.1186/s12958-023-01075-9. Reprod Biol Endocrinol. 2023. PMID: 36869381 Free PMC article.

114

Past and present: a bibliometric study on polycystic ovary syndrome.

Cai M, Ni Z, Yuan Z, Yu J, Zhang D, Yao R, Zhou L, Yu C. Cai M, et al. J Ovarian Res. 2023 Feb 18;16(1):42. doi: 10.1186/s13048-022-01072-3. J Ovarian Res. 2023. PMID: 36803912 Free PMC article.

115

The homeostasis model assessment of insulin resistance is a judgment criterion for metformin pre-treatment before IVF/ICSI and embryo transfer cycles in patients with polycystic ovarian syndrome.

Gao R, Qin L, Li Z, Min W. Gao R, et al. Front Endocrinol (Lausanne). 2023 Feb 9;14:1106276. doi: 10.3389/fendo.2023.1106276. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36843612 Free PMC article.

116

Circulating follistatin concentrations in adolescent PCOS: Divergent effects of randomized treatments.

Díaz M, de Zegher F, Ibáñez L. Díaz M, et al. Front Endocrinol (Lausanne). 2023 Feb 9;14:1125569. doi: 10.3389/fendo.2023.1125569. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36843579 Free PMC article. Clinical Trial.

117

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM. Greff D, et al. Reprod Biol Endocrinol. 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. Reprod Biol Endocrinol. 2023. PMID: 36703143 Free PMC article.

118

Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol.

Bassols J, de Zegher F, Diaz M, Carreras-Badosa G, Garcia-Beltran C, Puerto-Carranza E, Oliver-Vila C, Casano P, Franco CA, Malpique R, López-Bermejo A, Ibáñez L. Bassols J, et al. Trials. 2023 Jan 24;24(1):56. doi: 10.1186/s13063-022-07050-w. Trials. 2023. PMID: 36694227 Free PMC article.

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Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis.

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Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats.

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A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes.

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Metformin Treatment Regulates the Expression of Molecules Involved in Adiponectin and Insulin Signaling Pathways in Endometria from Women with Obesity-Associated Insulin Resistance and PCOS.

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The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome.

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Diane-35 and Metformin Induce Autophagy and Apoptosis in Polycystic Ovary Syndrome Women with Early-Stage Endometrial Carcinoma.

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Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area.

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Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis.

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The effects of myo-inositol vs. metformin on the ovarian function in the polycystic ovary syndrome: a systematic review and meta-analysis.

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The relative deficit of GDF15 in adolescent girls with PCOS can be changed into an abundance that reduces liver fat.

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Exenatide, Metformin, or Both for Prediabetes in PCOS: A Randomized, Open-label, Parallel-group Controlled Study.

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Research progress of metformin in gestational diabetes mellitus: a narrative review.

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Effects of metformin treatment on pregnancy outcomes in patients with polycystic ovary syndrome.

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Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.

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Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus.

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Successful IVF outcome after repeat laparoscopic ovarian drilling in a case of resistant PCOS.

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The clinical application of metformin in children and adolescents: A short update.

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Insulin Sensitizers for Improving the Endocrine and Metabolic Profile in Overweight Women With PCOS.

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Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome.

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The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats.

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Association of Metformin With Pregnancy Outcomes in Women With Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization: A Systematic Review and Meta-analysis.

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Metformin doses and body mass index: clinical outcomes in insulin resistant polycystic ovary syndrome women.

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Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.

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Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study.

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Combined use of Diane-35 and metformin improves the ovulation in the PCOS rat model possibly via regulating glycolysis pathway.

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Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: A systematic review and meta-analysis.

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Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK.

Jin J, Ma Y, Tong X, Yang W, Dai Y, Pan Y, Ren P, Liu L, Fan HY, Zhang Y, Zhang S. Jin J, et al. Hum Reprod. 2020 May 1;35(5):1145-1158. doi: 10.1093/humrep/deaa077. Hum Reprod. 2020. PMID: 32372097 Free PMC article.

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