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Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.
Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG. Vougas K, et al. Among authors: polyzos a. Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Pharmacol Ther. 2019. PMID: 31374225 Review.
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.
Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG. Galanos P, et al. Among authors: polyzos a. Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20. Nat Cell Biol. 2016. PMID: 27323328 Free PMC article.
A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.
Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG. Komseli ES, et al. Among authors: polyzos a. BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1. BMC Genomics. 2018. PMID: 29321003 Free PMC article.
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG. Galanos P, et al. Among authors: polyzos a. Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9. Genome Biol. 2018. PMID: 29548335 Free PMC article.
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks.
Di Giammartino DC, Kloetgen A, Polyzos A, Liu Y, Kim D, Murphy D, Abuhashem A, Cavaliere P, Aronson B, Shah V, Dephoure N, Stadtfeld M, Tsirigos A, Apostolou E. Di Giammartino DC, et al. Among authors: polyzos a. Nat Cell Biol. 2019 Oct;21(10):1179-1190. doi: 10.1038/s41556-019-0390-6. Epub 2019 Sep 23. Nat Cell Biol. 2019. PMID: 31548608 Free PMC article.
242 results