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Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G. Diarra D, et al. Among authors: polzer k. Nat Med. 2007 Feb;13(2):156-63. doi: 10.1038/nm1538. Epub 2007 Jan 21. Nat Med. 2007. PMID: 17237793
TNF-induced structural joint damage is mediated by IL-1.
Zwerina J, Redlich K, Polzer K, Joosten L, Krönke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasser J, Scheinecker C, Smolen JS, van den Berg W, Schett G. Zwerina J, et al. Among authors: polzer k. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11742-7. doi: 10.1073/pnas.0610812104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609389 Free PMC article.
Interleukin-1 is essential for systemic inflammatory bone loss.
Polzer K, Joosten L, Gasser J, Distler JH, Ruiz G, Baum W, Redlich K, Bobacz K, Smolen JS, van den Berg W, Schett G, Zwerina J. Polzer K, et al. Ann Rheum Dis. 2010 Jan;69(1):284-90. doi: 10.1136/ard.2008.104786. Ann Rheum Dis. 2010. PMID: 19196726
CTLA-4 directly inhibits osteoclast formation.
Axmann R, Herman S, Zaiss M, Franz S, Polzer K, Zwerina J, Herrmann M, Smolen J, Schett G. Axmann R, et al. Among authors: polzer k. Ann Rheum Dis. 2008 Nov;67(11):1603-9. doi: 10.1136/ard.2007.080713. Epub 2008 Jan 18. Ann Rheum Dis. 2008. PMID: 18203760
120 results