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Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations.
Branco MR, Pombo A. Branco MR, et al. Among authors: pombo a. PLoS Biol. 2006 May;4(5):e138. doi: 10.1371/journal.pbio.0040138. Epub 2006 Apr 25. PLoS Biol. 2006. PMID: 16623600 Free PMC article.
Here we use a novel high-resolution in situ hybridization procedure that preserves chromatin nanostructure to show that chromosome territories intermingle significantly in the nucleus of human cells. ...
Here we use a novel high-resolution in situ hybridization procedure that preserves chromatin nanostructure to show that chromosome te …
Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.
Fraser J, Ferrai C, Chiariello AM, Schueler M, Rito T, Laudanno G, Barbieri M, Moore BL, Kraemer DC, Aitken S, Xie SQ, Morris KJ, Itoh M, Kawaji H, Jaeger I, Hayashizaki Y, Carninci P, Forrest AR; FANTOM Consortium, Semple CA, Dostie J, Pombo A, Nicodemi M. Fraser J, et al. Among authors: pombo a. Mol Syst Biol. 2015 Dec 23;11(12):852. doi: 10.15252/msb.20156492. Mol Syst Biol. 2015. PMID: 26700852 Free PMC article.
Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation and show that they form a hierarchy of domains-within-domains (metaTADs) extending across genomic scales up to the range of entire chromosomes. ...Using polymer modelling, we demo …
Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation and show that they form a hierarchy of …
A polymer model explains the complexity of large-scale chromatin folding.
Barbieri M, Fraser J, Lavitas LM, Chotalia M, Dostie J, Pombo A, Nicodemi M. Barbieri M, et al. Among authors: pombo a. Nucleus. 2013 Jul-Aug;4(4):267-73. doi: 10.4161/nucl.25432. Epub 2013 Jun 19. Nucleus. 2013. PMID: 23823730 Free PMC article.
Hi-C methods have allowed for the detection of genome-wide chromatin interactions, revealing a complex large-scale organization where chromosomes tend to partition into megabase-sized "topological domains" of local chromatin interactions and intra-chromosomal contacts exte …
Hi-C methods have allowed for the detection of genome-wide chromatin interactions, revealing a complex large-scale organization where …
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.
Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AG. Landeira D, et al. Among authors: pombo a. Nat Cell Biol. 2010 Jun;12(6):618-24. doi: 10.1038/ncb2065. Epub 2010 May 16. Nat Cell Biol. 2010. PMID: 20473294 Free PMC article.
Here we show that Jarid2 is a novel subunit of PRC2 that is required for the co-recruitment of PRC1 and RNAP to genes that regulate development in ES cells. ...Instead, they show a severely compromised capacity for successful differentiation towards neural or mesode …
Here we show that Jarid2 is a novel subunit of PRC2 that is required for the co-recruitment of PRC1 and RNAP to genes that regulate d …
Three-dimensional genome architecture: players and mechanisms.
Pombo A, Dillon N. Pombo A, et al. Nat Rev Mol Cell Biol. 2015 Apr;16(4):245-57. doi: 10.1038/nrm3965. Epub 2015 Mar 11. Nat Rev Mol Cell Biol. 2015. PMID: 25757416 Review.
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Sabbattini P, Sjoberg M, Nikic S, Frangini A, Holmqvist PH, Kunowska N, Carroll T, Brookes E, Arthur SJ, Pombo A, Dillon N. Sabbattini P, et al. Among authors: pombo a. Mol Biol Cell. 2014 Mar;25(6):904-15. doi: 10.1091/mbc.E13-10-0628. Epub 2014 Jan 15. Mol Biol Cell. 2014. PMID: 24430871 Free PMC article.
Our results provide evidence of a novel developmentally regulated methyl-phospho switch that modulates Polycomb regulation in differentiated cells and stabilizes repressed states....
Our results provide evidence of a novel developmentally regulated methyl-phospho switch that modulates Polycomb regulation in differe …
Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease.
Möller A, Xie SQ, Hosp F, Lang B, Phatnani HP, James S, Ramirez F, Collin GB, Naggert JK, Babu MM, Greenleaf AL, Selbach M, Pombo A. Möller A, et al. Among authors: pombo a. Mol Cell Proteomics. 2012 Jun;11(6):M111.011767. doi: 10.1074/mcp.M111.011767. Epub 2011 Dec 22. Mol Cell Proteomics. 2012. PMID: 22199231 Free PMC article.
Polycomb targets seek closest neighbours.
Chotalia M, Pombo A. Chotalia M, et al. Among authors: pombo a. PLoS Genet. 2011 Mar;7(3):e1002031. doi: 10.1371/journal.pgen.1002031. Epub 2011 Mar 24. PLoS Genet. 2011. PMID: 21455485 Free PMC article. No abstract available.
Nuclear cell biology.
Pombo A, Starr DA. Pombo A, et al. Mol Biol Cell. 2011 Mar 15;22(6):722. doi: 10.1091/mbc.E10-12-0966. Mol Biol Cell. 2011. PMID: 21406585 Free PMC article. No abstract available.
Nuclear architecture in stem cells.
Morris KJ, Chotalia M, Pombo A. Morris KJ, et al. Among authors: pombo a. Adv Exp Med Biol. 2010;695:14-25. doi: 10.1007/978-1-4419-7037-4_2. Adv Exp Med Biol. 2010. PMID: 21222196
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