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Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.
Laco GS, Collins JR, Luke BT, Kroth H, Sayer JM, Jerina DM, Pommier Y. Laco GS, et al. Among authors: pommier y. Biochemistry. 2002 Feb 5;41(5):1428-35. doi: 10.1021/bi011774a. Biochemistry. 2002. PMID: 11814334
To elucidate top1 inhibition in vitro, we made a series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by a covalent adduct of benzo[a]pyrene (BaP) diol epoxide [Pommier, Y., et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 10739-107 …
To elucidate top1 inhibition in vitro, we made a series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by …
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