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RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.
Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA. Cranston AN, et al. Among authors: ponder ba. Cancer Res. 2006 Oct 15;66(20):10179-87. doi: 10.1158/0008-5472.CAN-06-0884. Cancer Res. 2006. PMID: 17047083
RET oncogene.
Mak YF, Ponder BA. Mak YF, et al. Among authors: ponder ba. Curr Opin Genet Dev. 1996 Feb;6(1):82-6. doi: 10.1016/s0959-437x(96)90015-5. Curr Opin Genet Dev. 1996. PMID: 8791480 Review.
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Maejima K, Ueda K, Masuda A, Dohmae N, Field HI, Tsunoda T, Kobayashi T, Akasu T, Sugiyama M, Ohnuma S, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R. Takawa M, et al. Among authors: ponder ba. Cancer Res. 2012 Jul 1;72(13):3217-27. doi: 10.1158/0008-5472.CAN-11-3701. Epub 2012 May 3. Cancer Res. 2012. PMID: 22556262
Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma.
Ruiz-Llorente S, Montero-Conde C, Milne RL, Moya CM, Cebrián A, Letón R, Cascón A, Mercadillo F, Landa I, Borrego S, Pérez de Nanclares G, Alvarez-Escolá C, Díaz-Pérez JA, Carracedo A, Urioste M, González-Neira A, Benítez J, Santisteban P, Dopazo J, Ponder BA, Robledo M; Medullary Thyroid Carcinoma Clinical Group. Ruiz-Llorente S, et al. Among authors: ponder ba. Cancer Res. 2007 Oct 1;67(19):9561-7. doi: 10.1158/0008-5472.CAN-07-1638. Cancer Res. 2007. PMID: 17909067
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