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K252a inhibits the oncogenic properties of Met, the HGF receptor.
Morotti A, Mila S, Accornero P, Tagliabue E, Ponzetto C. Morotti A, et al. Oncogene. 2002 Jul 25;21(32):4885-93. doi: 10.1038/sj.onc.1205622. Oncogene. 2002. PMID: 12118367
An in vivo model of Met-driven lymphoma as a tool to explore the therapeutic potential of Met inhibitors.
Accornero P, Lattanzio G, Mangano T, Chiarle R, Taulli R, Bersani F, Forni PE, Miretti S, Scuoppo C, Dastrù W, Christensen JG, Crepaldi T, Ponzetto C. Accornero P, et al. Among authors: ponzetto c. Clin Cancer Res. 2008 Apr 1;14(7):2220-6. doi: 10.1158/1078-0432.CCR-07-2064. Clin Cancer Res. 2008. PMID: 18381964 Free article.
Micro-orchestrating differentiation in cancer.
Taulli R, Bersani F, Ponzetto C. Taulli R, et al. Among authors: ponzetto c. Cell Cycle. 2010 Mar 1;9(5):918-22. doi: 10.4161/cc.9.5.10864. Epub 2010 Mar 7. Cell Cycle. 2010. PMID: 20160508
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation.
Taulli R, Bersani F, Foglizzo V, Linari A, Vigna E, Ladanyi M, Tuschl T, Ponzetto C. Taulli R, et al. Among authors: ponzetto c. J Clin Invest. 2009 Aug;119(8):2366-78. doi: 10.1172/JCI38075. Epub 2009 Jul 20. J Clin Invest. 2009. PMID: 19620785 Free PMC article.
RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.
Taulli R, Accornero P, Follenzi A, Mangano T, Morotti A, Scuoppo C, Forni PE, Bersani F, Crepaldi T, Chiarle R, Naldini L, Ponzetto C. Taulli R, et al. Cancer Gene Ther. 2005 May;12(5):456-63. doi: 10.1038/sj.cgt.7700815. Cancer Gene Ther. 2005. PMID: 15719029
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Piva R, Chiarle R, Manazza AD, Taulli R, Simmons W, Ambrogio C, D'Escamard V, Pellegrino E, Ponzetto C, Palestro G, Inghirami G. Piva R, et al. Blood. 2006 Jan 15;107(2):689-97. doi: 10.1182/blood-2005-05-2125. Epub 2005 Sep 27. Blood. 2006. PMID: 16189272 Free PMC article.
The oncogenic transcription factor PAX3-FKHR can convert fibroblasts into contractile myotubes.
Scuoppo C, Riess I, Schmitt-Ney M, Allegra P, Forni PE, Bersani F, Taulli R, Accornero P, Crepaldi T, Ponzetto C. Scuoppo C, et al. Exp Cell Res. 2007 Jul 1;313(11):2308-17. doi: 10.1016/j.yexcr.2007.02.037. Epub 2007 Apr 14. Exp Cell Res. 2007. PMID: 17490646
Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles.
Prunotto C, Crepaldi T, Forni PE, Ieraci A, Kelly RG, Tajbakhsh S, Buckingham M, Ponzetto C. Prunotto C, et al. Dev Dyn. 2004 Nov;231(3):582-91. doi: 10.1002/dvdy.20177. Dev Dyn. 2004. PMID: 15376315
The Pax3 and c-met genes are necessary for the development of tongue, diaphragm, and limb muscles. These hypaxial muscles derive from precursors that migrate out of the ventrolateral lip of the somites at occipital, cervical, and limb levels. In this work, we re-examined p …
The Pax3 and c-met genes are necessary for the development of tongue, diaphragm, and limb muscles. These hypaxial muscles derive from …
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma.
Taulli R, Scuoppo C, Bersani F, Accornero P, Forni PE, Miretti S, Grinza A, Allegra P, Schmitt-Ney M, Crepaldi T, Ponzetto C. Taulli R, et al. Cancer Res. 2006 May 1;66(9):4742-9. doi: 10.1158/0008-5472.CAN-05-4292. Cancer Res. 2006. PMID: 16651427
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