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After TGN1412: recent developments in cytokine release assays.
Stebbings R, Eastwood D, Poole S, Thorpe R. Stebbings R, et al. Among authors: poole s. J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11. J Immunotoxicol. 2013. PMID: 22967038 Free PMC article.
Antibody C region influences TGN1412-like functional activity in vitro.
Ball C, Fox B, Hufton S, Sharp G, Poole S, Stebbings R, Eastwood D, Findlay L, Parren PW, Thorpe R, Bristow A, Thorpe SJ. Ball C, et al. Among authors: poole s. J Immunol. 2012 Dec 15;189(12):5831-40. doi: 10.4049/jimmunol.1201795. Epub 2012 Nov 12. J Immunol. 2012. PMID: 23150712
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S. Stebbings R, et al. Among authors: poole s. J Immunol. 2007 Sep 1;179(5):3325-31. doi: 10.4049/jimmunol.179.5.3325. J Immunol. 2007. PMID: 17709549
Safety of biologics, lessons learnt from TGN1412.
Stebbings R, Poole S, Thorpe R. Stebbings R, et al. Among authors: poole s. Curr Opin Biotechnol. 2009 Dec;20(6):673-7. doi: 10.1016/j.copbio.2009.10.002. Epub 2009 Nov 4. Curr Opin Biotechnol. 2009. PMID: 19892543 Review.
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