Popel AS [Author] - Search Results

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337 results

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Computational methods and biomarker discovery strategies for spatial proteomics: a review in immuno-oncology.

Mi H, Sivagnanam S, Ho WJ, Zhang S, Bergman D, Deshpande A, Baras AS, Jaffee EM, Coussens LM, Fertig EJ, Popel AS. Mi H, et al. Among authors: popel as. Brief Bioinform. 2024 Jul 25;25(5):bbae421. doi: 10.1093/bib/bbae421. Brief Bioinform. 2024. PMID: 39179248 Free PMC article. Review.

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling.

Wang H, Arulraj T, Ippolito A, Popel AS. Wang H, et al. Among authors: popel as. NPJ Digit Med. 2024 Jul 16;7(1):189. doi: 10.1038/s41746-024-01188-4. NPJ Digit Med. 2024. PMID: 39014005 Free PMC article. Review.

Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery.

Zhang S, Deshpande A, Verma BK, Wang H, Mi H, Yuan L, Ho WJ, Jaffee EM, Zhu Q, Anders RA, Yarchoan M, Kagohara LT, Fertig EJ, Popel AS. Zhang S, et al. Among authors: popel as. Cancer Res. 2024 Aug 15;84(16):2734-2748. doi: 10.1158/0008-5472.CAN-24-0943. Cancer Res. 2024. PMID: 38861365

Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC.

Ippolito A, Wang H, Zhang Y, Vakil V, Popel AS. Ippolito A, et al. Among authors: popel as. J Pharmacokinet Pharmacodyn. 2024 Jun 10. doi: 10.1007/s10928-024-09928-5. Online ahead of print. J Pharmacokinet Pharmacodyn. 2024. PMID: 38858306

Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.

Arulraj T, Wang H, Deshpande A, Varadhan R, Emens LA, Jaffee EM, Fertig EJ, Santa-Maria CA, Popel AS. Arulraj T, et al. Among authors: popel as. bioRxiv [Preprint]. 2024 May 21:2024.05.21.595235. doi: 10.1101/2024.05.21.595235. bioRxiv. 2024. PMID: 38826266 Free PMC article. Preprint.

Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC.

Wang H, Arulraj T, Anbari S, Popel AS. Wang H, et al. Among authors: popel as. Clin Transl Sci. 2024 Jun;17(6):e13811. doi: 10.1111/cts.13811. Clin Transl Sci. 2024. PMID: 38814167 Free PMC article.

Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns from Breast Multiplexed Digital Pathology.

Wang Z, Santa-Maria CA, Popel AS, Sulam J. Wang Z, et al. Among authors: popel as. bioRxiv [Preprint]. 2024 Apr 26:2024.04.22.590118. doi: 10.1101/2024.04.22.590118. bioRxiv. 2024. PMID: 38712207 Free PMC article. Preprint.

Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth.

Furukawa N, Yang W, Chao AR, Patil A, Mirando AC, Pandey NB, Popel AS. Furukawa N, et al. Among authors: popel as. Cell Death Discov. 2024 Apr 2;10(1):161. doi: 10.1038/s41420-024-01932-5. Cell Death Discov. 2024. PMID: 38565596 Free PMC article.

Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology.

Arulraj T, Wang H, Ippolito A, Zhang S, Fertig EJ, Popel AS. Arulraj T, et al. Among authors: popel as. Brief Bioinform. 2024 Mar 27;25(3):bbae131. doi: 10.1093/bib/bbae131. Brief Bioinform. 2024. PMID: 38557676 Free PMC article.

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling.

Wang H, Arulraj T, Ippolito A, Popel AS. Wang H, et al. Among authors: popel as. ArXiv [Preprint]. 2024 Jun 23:arXiv:2403.03335v2. ArXiv. 2024. Update in: NPJ Digit Med. 2024 Jul 16;7(1):189. doi: 10.1038/s41746-024-01188-4. PMID: 38495562 Free PMC article. Updated. Preprint.

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