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113 results
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Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.
Poreba M, Salvesen GS, Drag M. Poreba M, et al. Nat Protoc. 2017 Oct;12(10):2189-2214. doi: 10.1038/nprot.2017.091. Epub 2017 Sep 21. Nat Protoc. 2017. PMID: 28933778
Current strategies for probing substrate specificity of proteases.
Poreba M, Drag M. Poreba M, et al. Curr Med Chem. 2010;17(33):3968-95. doi: 10.2174/092986710793205381. Curr Med Chem. 2010. PMID: 20939826 Review.
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.
Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M. Poreba M, et al. Biochimie. 2012 Mar;94(3):704-10. doi: 10.1016/j.biochi.2011.10.014. Epub 2011 Nov 7. Biochimie. 2012. PMID: 22085501
Mechanism and specificity of the human paracaspase MALT1.
Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS. Hachmann J, et al. Among authors: poreba m. Biochem J. 2012 Apr 1;443(1):287-95. doi: 10.1042/BJ20120035. Biochem J. 2012. PMID: 22309193 Free PMC article.
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M. Poreba M, et al. PLoS One. 2012;7(2):e31938. doi: 10.1371/journal.pone.0031938. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359643 Free PMC article.
An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.
Węglarz-Tomczak E, Poręba M, Byzia A, Berlicki Ł, Nocek B, Mulligan R, Joachimiak A, Drąg M, Mucha A. Węglarz-Tomczak E, et al. Among authors: poreba m. Biochimie. 2013 Feb;95(2):419-28. doi: 10.1016/j.biochi.2012.10.018. Epub 2012 Nov 3. Biochimie. 2013. PMID: 23131591 Free PMC article.
Caspase substrates and inhibitors.
Poreba M, Strózyk A, Salvesen GS, Drag M. Poreba M, et al. Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. doi: 10.1101/cshperspect.a008680. Cold Spring Harb Perspect Biol. 2013. PMID: 23788633 Free PMC article. Review.
Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.
Poreba M, Mihelic M, Krai P, Rajkovic J, Krezel A, Pawelczak M, Klemba M, Turk D, Turk B, Latajka R, Drag M. Poreba M, et al. Amino Acids. 2014 Apr;46(4):931-43. doi: 10.1007/s00726-013-1654-2. Epub 2014 Jan 1. Amino Acids. 2014. PMID: 24381006 Free PMC article.
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.
Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M. Kasperkiewicz P, et al. Among authors: poreba m. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23. doi: 10.1073/pnas.1318548111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24550277 Free PMC article.
Positional scanning substrate combinatorial library (PS-SCL) approach to define caspase substrate specificity.
Poręba M, Szalek A, Kasperkiewicz P, Drąg M. Poręba M, et al. Methods Mol Biol. 2014;1133:41-59. doi: 10.1007/978-1-4939-0357-3_2. Methods Mol Biol. 2014. PMID: 24567093
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