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Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.
Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN. Porgador A, et al. Immunity. 1997 Jun;6(6):715-26. doi: 10.1016/s1074-7613(00)80447-1. Immunity. 1997. PMID: 9208844
Here we describe a method for eliciting and identifying monoclonal antibodies specific for a particular peptide-MHC class I combination. One such antibody can identify antigen complexes with a limit of detection approaching that of T cells. We used this antib …
Here we describe a method for eliciting and identifying monoclonal antibodies specific for a particular peptide-MHC class I co …
Identification of Salmonella typhimurium genes responsible for interference with peptide presentation on MHC class I molecules: Deltayej Salmonella mutants induce superior CD8+ T-cell responses.
Qimron U, Madar N, Mittrücker HW, Zilka A, Yosef I, Bloushtain N, Kaufmann SH, Rosenshine I, Apte RN, Porgador A. Qimron U, et al. Among authors: porgador a. Cell Microbiol. 2004 Nov;6(11):1057-70. doi: 10.1111/j.1462-5822.2004.00418.x. Cell Microbiol. 2004. PMID: 15469434
Two mutants undergoing enhanced antigen presentation by macrophages were identified, carrying a Tn10d insertion in the yej operon. ...In accordance with their enhanced MHC-I presentation phenotype, we showed that (i) specific CD8+ T cells were elicited at a higher l …
Two mutants undergoing enhanced antigen presentation by macrophages were identified, carrying a Tn10d insertion in the yej operon. .. …
Classification of current anticancer immunotherapies.
Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, Apte RN, Aranda F, Ayyoub M, Beckhove P, Blay JY, Bracci L, Caignard A, Castelli C, Cavallo F, Celis E, Cerundolo V, Clayton A, Colombo MP, Coussens L, Dhodapkar MV, Eggermont AM, Fearon DT, Fridman WH, Fučíková J, Gabrilovich DI, Galon J, Garg A, Ghiringhelli F, Giaccone G, Gilboa E, Gnjatic S, Hoos A, Hosmalin A, Jäger D, Kalinski P, Kärre K, Kepp O, Kiessling R, Kirkwood JM, Klein E, Knuth A, Lewis CE, Liblau R, Lotze MT, Lugli E, Mach JP, Mattei F, Mavilio D, Melero I, Melief CJ, Mittendorf EA, Moretta L, Odunsi A, Okada H, Palucka AK, Peter ME, Pienta KJ, Porgador A, Prendergast GC, Rabinovich GA, Restifo NP, Rizvi N, Sautès-Fridman C, Schreiber H, Seliger B, Shiku H, Silva-Santos B, Smyth MJ, Speiser DE, Spisek R, Srivastava PK, Talmadge JE, Tartour E, Van Der Burg SH, Van Den Eynde BJ, Vile R, Wagner H, Weber JS, Whiteside TL, Wolchok JD, Zitvogel L, Zou W, Kroemer G. Galluzzi L, et al. Among authors: porgador a. Oncotarget. 2014 Dec 30;5(24):12472-508. doi: 10.18632/oncotarget.2998. Oncotarget. 2014. PMID: 25537519 Free PMC article. Review.
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. ...While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a re …
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality …
Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue.
Porgador A, Staats HF, Itoh Y, Kelsall BL. Porgador A, et al. Infect Immun. 1998 Dec;66(12):5876-81. doi: 10.1128/IAI.66.12.5876-5881.1998. Infect Immun. 1998. PMID: 9826368 Free PMC article.
We previously reported that cholera toxin (CT) was required as a mucosal adjuvant for the induction of peptide-specific cytotoxic T lymphocytes (CTL) following intranasal immunization with CTL epitope peptides (A. Porgador et al., J. Immunol. 158:834-841, 199 …
We previously reported that cholera toxin (CT) was required as a mucosal adjuvant for the induction of peptide-specific cytotoxic T l …
Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.
Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN. Porgador A, et al. J Exp Med. 1998 Sep 21;188(6):1075-82. doi: 10.1084/jem.188.6.1075. J Exp Med. 1998. PMID: 9743526 Free PMC article.
Under these conditions, two possible modes of DC antigen presentation to naive CD8+ T cells might exist: (a) presentation directly by gene-transfected DC trafficking to local lymph nodes, and (b) cross-presentation by untransfected DC of antigen released from or associated …
Under these conditions, two possible modes of DC antigen presentation to naive CD8+ T cells might exist: (a) presentation directly by …
Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors.
Deng Y, Gibbs J, Bacík I, Porgador A, Copeman J, Lehner P, Ortmann B, Cresswell P, Bennink JR, Yewdell JW. Deng Y, et al. Among authors: porgador a. J Immunol. 1998 Aug 15;161(4):1677-85. J Immunol. 1998. PMID: 9712031
Insects lack a class I recognition system, and their cells therefore provide a "blank slate" for identifying the proteins that have evolved to facilitate assembly of class I molecules in vertebrate cells. ...Cell surface expression of Kb-OVA(257-264) complexes was q …
Insects lack a class I recognition system, and their cells therefore provide a "blank slate" for identifying the proteins that …
Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides.
Antón LC, Snyder HL, Bennink JR, Vinitsky A, Orlowski M, Porgador A, Yewdell JW. Antón LC, et al. Among authors: porgador a. J Immunol. 1998 May 15;160(10):4859-68. J Immunol. 1998. PMID: 9590233
The inhibitors were used at sufficient concentrations to block presentation of biosynthesized full-length OVA and to completely stabilize a rapidly degraded chimeric ubiquitin-NP fusion protein. ...
The inhibitors were used at sufficient concentrations to block presentation of biosynthesized full-length OVA and to completely stabilize …
Calnexin expression does not enhance the generation of MHC class I-peptide complexes.
Prasad SA, Yewdell JW, Porgador A, Sadasivan B, Cresswell P, Bennink JR. Prasad SA, et al. Among authors: porgador a. Eur J Immunol. 1998 Mar;28(3):907-13. doi: 10.1002/(SICI)1521-4141(199803)28:03<907::AID-IMMU907>3.0.CO;2-4. Eur J Immunol. 1998. PMID: 9541586
This was detected with a recently described monoclonal antibody specific for the Kb/peptide complex. Calnexin expression had no significant effect on the formation of Kb/peptide complexes generated from full-length OVA, cytosolic OVA257-264, or endoplasmic reticulum-target …
This was detected with a recently described monoclonal antibody specific for the Kb/peptide complex. Calnexin expression had no signi …
Natural killer cell lines kill autologous beta2-microglobulin-deficient melanoma cells: implications for cancer immunotherapy.
Porgador A, Mandelboim O, Restifo NP, Strominger JL. Porgador A, et al. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13140-5. doi: 10.1073/pnas.94.24.13140. Proc Natl Acad Sci U S A. 1997. PMID: 9371813 Free PMC article.
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells.
Day PM, Yewdell JW, Porgador A, Germain RN, Bennink JR. Day PM, et al. Among authors: porgador a. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8064-9. doi: 10.1073/pnas.94.15.8064. Proc Natl Acad Sci U S A. 1997. PMID: 9223315 Free PMC article.
ER delivery of a nonfluorescent peptide was demonstrated using a mAb highly specific for the peptide-class I molecule complex. ...These findings demonstrate the existence of a pathway, likely vesicular in nature, that conveys small extracellular substances to …
ER delivery of a nonfluorescent peptide was demonstrated using a mAb highly specific for the peptide-class I molecule complex. …
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