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Small-t and large-T antigens cooperate to drive cell proliferation.
Rundell K, Gaillard S, Porrás A. Rundell K, et al. Among authors: porras a. Dev Biol Stand. 1998;94:289-95. Dev Biol Stand. 1998. PMID: 9776249
The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts.
Porrás A, Gaillard S, Rundell K. Porrás A, et al. J Virol. 1999 Apr;73(4):3102-7. doi: 10.1128/JVI.73.4.3102-3107.1999. J Virol. 1999. PMID: 10074161 Free PMC article.
Small-t antigen and, to a lesser extent, large-T antigen increased the level of the S phase cyclin cyclin A but without increasing the activity of associated cyclin kinases unless the two SV40 proteins were coexpressed. ...
Small-t antigen and, to a lesser extent, large-T antigen increased the level of the S phase cyclin cyclin A but without increa …
A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.
Porrás A, Bennett J, Howe A, Tokos K, Bouck N, Henglein B, Sathyamangalam S, Thimmapaya B, Rundell K. Porrás A, et al. J Virol. 1996 Oct;70(10):6902-8. doi: 10.1128/JVI.70.10.6902-6908.1996. J Virol. 1996. PMID: 8794333 Free PMC article.
Second, small-t was found to provide a function previously identified as a large-T transformation domain. Mutations in residues 19 to 28 of large-T affected its transforming ability, but these mutations were complemented by a wild-type small-t. A third …
Second, small-t was found to provide a function previously identified as a large-T transformation domain. Mutations in residue …
Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.
Mungre S, Enderle K, Turk B, Porrás A, Wu YQ, Mumby MC, Rundell K. Mungre S, et al. Among authors: porras a. J Virol. 1994 Mar;68(3):1675-81. doi: 10.1128/JVI.68.3.1675-1681.1994. J Virol. 1994. PMID: 8107228 Free PMC article.
These mutations affected the interaction of small-t antigen with the protein phosphatase 2A A subunit translated in vitro, and a peptide from the region identified by these mutations released the A subunit from immune complexes. ...In contrast, the mutant sma …
These mutations affected the interaction of small-t antigen with the protein phosphatase 2A A subunit translated in vitro, and a
Simian virus 40 small-t antigen binds two zinc ions.
Turk B, Porras A, Mumby MC, Rundell K. Turk B, et al. Among authors: porras a. J Virol. 1993 Jun;67(6):3671-3. doi: 10.1128/JVI.67.6.3671-3673.1993. J Virol. 1993. PMID: 8388518 Free PMC article.
Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster....
Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster....
Microtubule-dependent intracellular transport of murine polyomavirus.
Sanjuan N, Porrás A, Otero J. Sanjuan N, et al. Among authors: porras a. Virology. 2003 Aug 15;313(1):105-16. doi: 10.1016/s0042-6822(03)00309-x. Virology. 2003. PMID: 12951025
Expression of major capsid protein VP-1 in the absence of viral particles in thymomas induced by murine polyomavirus.
Sanjuan N, Porrás A, Otero J, Perazzo S. Sanjuan N, et al. Among authors: porras a. J Virol. 2001 Mar;75(6):2891-9. doi: 10.1128/JVI.75.6.2891-2899.2001. J Virol. 2001. PMID: 11222714 Free PMC article.
Since the expression of a late structural protein such as VP-1 is considered a sign of virus replication, the present work attempted to clarify the implication of the presence of this protein in tumor cells. ...A change in the electrophoretic mobility of VP-1 …
Since the expression of a late structural protein such as VP-1 is considered a sign of virus replication, the present work att …
Neurocranium thickness mapping in early childhood.
Gajawelli N, Deoni S, Shi J, Linguraru MG, Porras AR, Nelson MD, Tamrazi B, Rajagopalan V, Wang Y, Lepore N. Gajawelli N, et al. Among authors: porras ar. Sci Rep. 2020 Oct 6;10(1):16651. doi: 10.1038/s41598-020-73589-w. Sci Rep. 2020. PMID: 33024168 Free PMC article.
Incidence and mortality of pertussis disease in infants <12 months of age following introduction of pertussis maternal universal mass vaccination in Bogotá, Colombia.
Carrasquilla G, Porras A, Martinez S, DeAntonio R, Devadiga R, Caceres DC, Juliao P. Carrasquilla G, et al. Among authors: porras a. Vaccine. 2020 Oct 27;38(46):7384-7392. doi: 10.1016/j.vaccine.2020.07.046. Epub 2020 Oct 2. Vaccine. 2020. PMID: 33012607 Free article.
C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation.
Sequera C, Bragado P, Manzano S, Arechederra M, Richelme S, Gutiérrez-Uzquiza A, Sánchez A, Maina F, Guerrero C, Porras A. Sequera C, et al. Among authors: porras a. Cancers (Basel). 2020 Aug 14;12(8):2282. doi: 10.3390/cancers12082282. Cancers (Basel). 2020. PMID: 32823931 Free PMC article.
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