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A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: porreca f. J Med Chem. 2008 Mar 13;51(5):1369-76. doi: 10.1021/jm070332f. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266313 Free PMC article.
Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord.
Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Lee YS, et al. Among authors: porreca f. J Am Chem Soc. 2014 May 7;136(18):6608-16. doi: 10.1021/ja501677q. Epub 2014 Apr 29. J Am Chem Soc. 2014. PMID: 24742335 Free PMC article.
Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.
Ramos-Colon CN, Lee YS, Remesic M, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher J, Porreca F, Hruby VJ. Ramos-Colon CN, et al. Among authors: porreca f. J Med Chem. 2016 Nov 23;59(22):10291-10298. doi: 10.1021/acs.jmedchem.6b01411. Epub 2016 Nov 8. J Med Chem. 2016. PMID: 27797517 Free PMC article.
Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.
Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Deekonda S, et al. Among authors: porreca f. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4683-8. doi: 10.1016/j.bmcl.2015.07.064. Epub 2015 Jul 29. Bioorg Med Chem Lett. 2015. PMID: 26323872 Free PMC article.
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Deekonda S, et al. Among authors: porreca f. Bioorg Med Chem. 2015 Sep 15;23(18):6185-94. doi: 10.1016/j.bmc.2015.07.071. Epub 2015 Aug 4. Bioorg Med Chem. 2015. PMID: 26299827 Free PMC article.
602 results