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The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis.
Pellerito O, Calvaruso G, Portanova P, De Blasio A, Santulli A, Vento R, Tesoriere G, Giuliano M. Pellerito O, et al. Among authors: portanova p. Mol Pharmacol. 2010 May;77(5):854-63. doi: 10.1124/mol.109.062257. Epub 2010 Feb 16. Mol Pharmacol. 2010. PMID: 20159939
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