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Epigenetic modifications and human disease.
Portela A, Esteller M. Portela A, et al. Nat Biotechnol. 2010 Oct;28(10):1057-68. doi: 10.1038/nbt.1685. Nat Biotechnol. 2010. PMID: 20944598 Review.
The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, the finding of new histone variants and modifications, and the unveiling of genome-wide nucleosome positioning maps highlight the accelerating spee …
The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, the fin …
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer.
Lujambio A, Portela A, Liz J, Melo SA, Rossi S, Spizzo R, Croce CM, Calin GA, Esteller M. Lujambio A, et al. Among authors: portela a. Oncogene. 2010 Dec 2;29(48):6390-401. doi: 10.1038/onc.2010.361. Epub 2010 Aug 30. Oncogene. 2010. PMID: 20802525 Free PMC article.
We used a pharmacological and genomic approach to reveal the possible existence of an aberrant epigenetic silencing pattern of T-UCRs by treating cancer cells with a DNA-demethylating agent followed by hybridization to an expression microarray containing these seque …
We used a pharmacological and genomic approach to reveal the possible existence of an aberrant epigenetic silencing pattern of T-UCRs …
DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes.
Portela A, Liz J, Nogales V, Setién F, Villanueva A, Esteller M. Portela A, et al. Oncogene. 2013 Nov 21;32(47):5421-8. doi: 10.1038/onc.2013.162. Epub 2013 May 20. Oncogene. 2013. PMID: 23686312 Free PMC article.
Using a cancer model and digital nucleosome positioning techniques, we demonstrate that the induction of DNA hypomethylation events by genetic (DNMT1/DNMT3B deficient cells) or drug (a DNA demethylating agent) approaches is associated with the eviction of nucleosome …
Using a cancer model and digital nucleosome positioning techniques, we demonstrate that the induction of DNA hypomethylation events b …
DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.
Villanueva A, Portela A, Sayols S, Battiston C, Hoshida Y, Méndez-González J, Imbeaud S, Letouzé E, Hernandez-Gea V, Cornella H, Pinyol R, Solé M, Fuster J, Zucman-Rossi J, Mazzaferro V, Esteller M, Llovet JM; HEPTROMIC Consortium. Villanueva A, et al. Among authors: portela a. Hepatology. 2015 Jun;61(6):1945-56. doi: 10.1002/hep.27732. Epub 2015 Mar 18. Hepatology. 2015. PMID: 25645722
Analysis of tumor tissue from 304 patients with HCC treated with surgical resection allowed us to generate a methylation-based prognostic signature using a training-validation scheme. ...Random survival forests enabled us to generate a methylation signature b …
Analysis of tumor tissue from 304 patients with HCC treated with surgical resection allowed us to generate a methylation-based progno …
Exploiting tumor vulnerabilities: epigenetics, cancer metabolism and the mTOR pathway in the era of personalized medicine.
Muñoz-Pinedo C, González-Suárez E, Portela A, Gentilella A, Esteller M. Muñoz-Pinedo C, et al. Among authors: portela a. Cancer Res. 2013 Jul 15;73(14):4185-9. doi: 10.1158/0008-5472.CAN-13-0512. Epub 2013 May 17. Cancer Res. 2013. PMID: 23687347
Patient stratification according to drug responses, together with the discovery of novel antitumor targets, is leading to a new era of personalized cancer treatments. ...
Patient stratification according to drug responses, together with the discovery of novel antitumor targets, is leading to a new era o …
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models.
Martinez-Quetglas I, Pinyol R, Dauch D, Torrecilla S, Tovar V, Moeini A, Alsinet C, Portela A, Rodriguez-Carunchio L, Solé M, Lujambio A, Villanueva A, Thung S, Esteller M, Zender L, Llovet JM. Martinez-Quetglas I, et al. Among authors: portela a. Gastroenterology. 2016 Dec;151(6):1192-1205. doi: 10.1053/j.gastro.2016.09.001. Epub 2016 Sep 7. Gastroenterology. 2016. PMID: 27614046
Mice with xenograft tumors grown from HCC cells were given a monoclonal antibody against IGF1 and IGF2 (xentuzumab), along with sorafenib; tumor growth was measured and tissues were analyzed by immunohistochemistry and immunoblots. ...CONCLUSIONS: A large proportion …
Mice with xenograft tumors grown from HCC cells were given a monoclonal antibody against IGF1 and IGF2 (xentuzumab), along with soraf …
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Martínez-Cardús A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal A, Martinez-Iniesta M, Manzano JL, Fernandez-Figueras MT, Elez E, Muñoz-Couselo E, Botella-Estrada R, Berrocal A, Pontén F, Oord Jv, Gallagher WM, Frederick DT, Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M. Vizoso M, et al. Among authors: portela a. Nat Med. 2015 Jul;21(7):741-50. doi: 10.1038/nm.3863. Epub 2015 Jun 1. Nat Med. 2015. PMID: 26030178 Free PMC article.
We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; referred to hereafter as TBC1D16-47KD) to be a characteristic feature of the metastatic cascade. ...By combining immunoprecipi …
We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-4 …
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation.
Boque-Sastre R, Soler M, Oliveira-Mateos C, Portela A, Moutinho C, Sayols S, Villanueva A, Esteller M, Guil S. Boque-Sastre R, et al. Among authors: portela a. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5785-90. doi: 10.1073/pnas.1421197112. Epub 2015 Apr 22. Proc Natl Acad Sci U S A. 2015. PMID: 25902512 Free PMC article.
Herein, we have addressed this issue for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and tissue integrity that is deregulated in different types of cancer. ...These results are the first examples to our knowledge of R-loop-mediate …
Herein, we have addressed this issue for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and t …
Intronic RNAs mediate EZH2 regulation of epigenetic targets.
Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M. Guil S, et al. Among authors: portela a. Nat Struct Mol Biol. 2012 Jun 3;19(7):664-70. doi: 10.1038/nsmb.2315. Nat Struct Mol Biol. 2012. PMID: 22659877
Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role for some RNA molecules in guiding repressive polycomb complex PRC2 to specific chromatin regions has been proposed. Here we use an in vivo cross-linking method to detect an …
Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role for some RNA molecules in guidin …
Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer.
Iliou MS, Lujambio A, Portela A, Brüstle O, Koch P, Andersson-Vincent PH, Sundström E, Hovatta O, Esteller M. Iliou MS, et al. Among authors: portela a. Epigenetics. 2011 Nov;6(11):1344-53. doi: 10.4161/epi.6.11.18021. Epub 2011 Nov 1. Epigenetics. 2011. PMID: 22048248
It has been proposed that the existence of stem cell epigenetic patterns confer a greater likelihood of CpG island hypermethylation on tumor suppressor-coding genes in cancer. ...Our results suggest that there is a positive correlation between the existence of bival …
It has been proposed that the existence of stem cell epigenetic patterns confer a greater likelihood of CpG island hypermethylation o …
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