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A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions.
Humberstone AJ, Currie GJ, Porter CJ, Scanlon MJ, Charman WN. Humberstone AJ, et al. J Pharm Biomed Anal. 1995 Mar;13(3):265-72. doi: 10.1016/0731-7085(95)01256-k. J Pharm Biomed Anal. 1995. PMID: 7619886
Model systems for intestinal lymphatic transport studies.
Porter CJ, Charman WN. Porter CJ, et al. Pharm Biotechnol. 1996;8:85-102. doi: 10.1007/978-1-4899-1863-5_6. Pharm Biotechnol. 1996. PMID: 8791806 Review. No abstract available.
Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion.
Porter CJ, Charman SA, Humberstone AJ, Charman WN. Porter CJ, et al. J Pharm Sci. 1996 Apr;85(4):357-61. doi: 10.1021/js9502229. J Pharm Sci. 1996. PMID: 8901068
Differences in pre- and post-prandial plasma lipid profiles affect the extraction efficiency of a model highly lipophilic drug from beagle dog plasma.
Porter CJ, Caliph SM, Charman WN. Porter CJ, et al. J Pharm Biomed Anal. 1997 Sep;16(1):175-80. doi: 10.1016/s0731-7085(97)00008-3. J Pharm Biomed Anal. 1997. PMID: 9447565 No abstract available.
Drug delivery to the lymphatic system.
Porter CJ. Porter CJ. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93. Crit Rev Ther Drug Carrier Syst. 1997. PMID: 9450175 Review.
Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: in vitro studies in normolipidemic and dyslipidemic human plasmas.
Wasan KM, Ramaswamy M, McIntosh MP, Porter CJ, Charman WN. Wasan KM, et al. J Pharm Sci. 1999 Feb;88(2):185-90. doi: 10.1021/js980353k. J Pharm Sci. 1999. PMID: 9950636
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