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Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine.
Henkel JG, Portoghese PS, Miller JW, Lewis P. Henkel JG, et al. Among authors: portoghese ps. J Med Chem. 1976 Jan;19(1):6-10. doi: 10.1021/jm00223a002. J Med Chem. 1976. PMID: 1536
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE. Portoghese PS, et al. J Med Chem. 1980 Mar;23(3):233-4. doi: 10.1021/jm00177a002. J Med Chem. 1980. PMID: 6245210 No abstract available.
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
Portoghese PS, Larson DL, Jiang JB, Takemori AE, Caruso TP. Portoghese PS, et al. J Med Chem. 1978 Jul;21(7):598-9. doi: 10.1021/jm00205a002. J Med Chem. 1978. PMID: 209185 No abstract available.
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.
Sayre LM, Larson DL, Takemori AE, Portoghese PS. Sayre LM, et al. Among authors: portoghese ps. J Med Chem. 1984 Oct;27(10):1325-35. doi: 10.1021/jm00376a018. J Med Chem. 1984. PMID: 6090663
Different receptor sites mediate opioid agonism and antagonism.
Portoghese PS, Takemori AE. Portoghese PS, et al. J Med Chem. 1983 Oct;26(10):1341-3. doi: 10.1021/jm00364a001. J Med Chem. 1983. PMID: 6312042 No abstract available.
Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities.
Sayre LM, Takemori AE, Portoghese PS. Sayre LM, et al. Among authors: portoghese ps. J Med Chem. 1983 Apr;26(4):503-6. doi: 10.1021/jm00358a009. J Med Chem. 1983. PMID: 6300401
Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels.
Sayre LM, Larson DL, Fries DS, Takemori AE, Portoghese PS. Sayre LM, et al. Among authors: portoghese ps. J Med Chem. 1983 Sep;26(9):1229-35. doi: 10.1021/jm00363a005. J Med Chem. 1983. PMID: 6310111
Stereochemical studies on medicinal agents. 9. Bicyclic bases. Synthesis and biological activities of epimeric quaternary derivatives of 2-oxa-5-azabicyclo [2.2.1]heptane.
Portoghese PS, Turcotte JG. Portoghese PS, et al. J Med Chem. 1971 Apr;14(4):288-91. doi: 10.1021/jm00286a005. J Med Chem. 1971. PMID: 5553738 No abstract available.
Potential nonequilibrium analgetic receptor inactivators. Synthesis and biological activities of N-acylanileridines.
Portoghese PS, Telang VG, Takemori AE, Hayashi G. Portoghese PS, et al. J Med Chem. 1971 Feb;14(2):144-8. doi: 10.1021/jm00284a015. J Med Chem. 1971. PMID: 5107751 No abstract available.
Stereochemical studies on medicinal agents. V. Synthesis, configuration, and pharmacological activity of pipradrol enantiomers.
Portoghese PS, Pazdernik TL, Kuhn WL, Hite G, Shafi'ee A. Portoghese PS, et al. J Med Chem. 1968 Jan;11(1):12-5. doi: 10.1021/jm00307a002. J Med Chem. 1968. PMID: 4384128 No abstract available.
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