Portoghese PS - Search Results

1

An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.

Portoghese PS. Portoghese PS. J Med Chem. 1991 Jun;34(6):1757-62. doi: 10.1021/jm00110a001. J Med Chem. 1991. PMID: 1648136

2

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.

Aceto MD, Harris LS, Negus SS, Banks ML, Hughes LD, Akgün E, Portoghese PS. Aceto MD, et al. Among authors: portoghese ps. Int J Med Chem. 2012;2012:327257. doi: 10.1155/2012/327257. Epub 2012 Apr 29. Int J Med Chem. 2012. PMID: 25954526 Free PMC article.

3

A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm.

Tang Y, Yang J, Lunzer MM, Powers MD, Portoghese PS. Tang Y, et al. Among authors: portoghese ps. ACS Med Chem Lett. 2010 Oct 27;2(1):7-10. doi: 10.1021/ml1001294. eCollection 2011 Jan 13. ACS Med Chem Lett. 2010. PMID: 24936231 Free PMC article.

4

Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR. Pravetoni M, et al. Among authors: portoghese ps. J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23249238 Free PMC article.

5

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS. Le Naour M, et al. Among authors: portoghese ps. J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23734559 Free PMC article.

6

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.

Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS. Daniels DJ, et al. Among authors: portoghese ps. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19208-13. doi: 10.1073/pnas.0506627102. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365317 Free PMC article.

7

Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.

Lunzer MM, Portoghese PS. Lunzer MM, et al. Among authors: portoghese ps. J Pharmacol Exp Ther. 2007 Jul;322(1):166-71. doi: 10.1124/jpet.107.120279. Epub 2007 Mar 30. J Pharmacol Exp Ther. 2007. PMID: 17400888

8

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.

Daniels DJ, Kulkarni A, Xie Z, Bhushan RG, Portoghese PS. Daniels DJ, et al. Among authors: portoghese ps. J Med Chem. 2005 Mar 24;48(6):1713-6. doi: 10.1021/jm034234f. J Med Chem. 2005. PMID: 15771416

9

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.

Bhushan RG, Sharma SK, Xie Z, Daniels DJ, Portoghese PS. Bhushan RG, et al. Among authors: portoghese ps. J Med Chem. 2004 Jun 3;47(12):2969-72. doi: 10.1021/jm0342358. J Med Chem. 2004. PMID: 15163177

10

Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.

Portoghese PS, Law PY, Loh HH. Portoghese PS, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):207-10. doi: 10.1016/j.ejphar.2003.08.041. Eur J Pharmacol. 2003. PMID: 14575806

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