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A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans.
Schwab D, Portron A, Backholer Z, Lausecker B, Kawashima K. Schwab D, et al. Among authors: portron a. Clin Pharmacokinet. 2013 Jun;52(6):463-73. doi: 10.1007/s40262-013-0051-z. Clin Pharmacokinet. 2013. PMID: 23494983 Clinical Trial.
Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 after single subcutaneous administration in healthy subjects.
Portron A, Jadidi S, Sarkar N, DiMarchi R, Schmitt C. Portron A, et al. Diabetes Obes Metab. 2017 Oct;19(10):1446-1453. doi: 10.1111/dom.13025. Epub 2017 Jul 25. Diabetes Obes Metab. 2017. PMID: 28741871 Clinical Trial.
Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus.
Schmitt C, Portron A, Jadidi S, Sarkar N, DiMarchi R. Schmitt C, et al. Among authors: portron a. Diabetes Obes Metab. 2017 Oct;19(10):1436-1445. doi: 10.1111/dom.13024. Epub 2017 Jul 20. Diabetes Obes Metab. 2017. PMID: 28730694 Clinical Trial.
Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Tofogliflozin (A SELECTIVE SGLT2 Inhibitor) in Patients with Type 2 Diabetes Mellitus.
Ikeda S, Takano Y, Schwab D, Portron A, Kasahara-Ito N, Saito T, Iida S. Ikeda S, et al. Among authors: portron a. Drug Res (Stuttg). 2019 Jun;69(6):314-322. doi: 10.1055/a-0662-0209. Epub 2018 Aug 13. Drug Res (Stuttg). 2019. PMID: 30103216 Clinical Trial.
Phase I clinical study to select a novel oral formulation for ibandronate containing the excipient sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC).
Bittner B, McIntyre C, Tian H, Tang K, Shah N, Phuapradit W, Ahmed H, Chokshi H, Infeld M, Fotaki N, Ma H, Portron A, Jordan P, Schmidt J. Bittner B, et al. Pharmazie. 2012 Mar;67(3):233-41. Pharmazie. 2012. PMID: 22530305 Clinical Trial.
The highest mean IBN exposure was achieved with a capsule formulation containing drug-coated beadlets and an IBN:SNAC ratio of 1:5. ...Increasing the post-dose fasting duration from 15 to 30 min resulted in a more than 2-fold increase in AUC(last), while superimposa …
The highest mean IBN exposure was achieved with a capsule formulation containing drug-coated beadlets and an IBN:SNAC ratio of 1:5. . …
Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study.
Schwab D, Sturm C, Portron A, Fuerst-Recktenwald S, Hainzl D, Jordan P, Stewart WC, Tepedino ME, DuBiner H. Schwab D, et al. Among authors: portron a. BMJ Open Ophthalmol. 2017 Jun 29;1(1):e000063. doi: 10.1136/bmjophth-2016-000063. eCollection 2017. BMJ Open Ophthalmol. 2017. PMID: 29354707 Free PMC article.
A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers.
Portron A, Jordan P, Draper K, Muenzer C, Dickerson D, van Iersel T, Hofmann C. Portron A, et al. Clin Ther. 2020 Jan;42(1):108-120.e1. doi: 10.1016/j.clinthera.2019.11.015. Epub 2019 Dec 26. Clin Ther. 2020. PMID: 31883703 Free article. Clinical Trial.
Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.
Pipe SW, Shima M, Lehle M, Shapiro A, Chebon S, Fukutake K, Key NS, Portron A, Schmitt C, Podolak-Dawidziak M, Selak Bienz N, Hermans C, Campinha-Bacote A, Kiialainen A, Peerlinck K, Levy GG, Jiménez-Yuste V. Pipe SW, et al. Among authors: portron a. Lancet Haematol. 2019 Jun;6(6):e295-e305. doi: 10.1016/S2352-3026(19)30054-7. Epub 2019 Apr 16. Lancet Haematol. 2019. PMID: 31003963 Clinical Trial.
Continuous Auditory Feedback of Eye Movements: An Exploratory Study toward Improving Oculomotor Control.
Boyer EO, Portron A, Bevilacqua F, Lorenceau J. Boyer EO, et al. Among authors: portron a. Front Neurosci. 2017 Apr 25;11:197. doi: 10.3389/fnins.2017.00197. eCollection 2017. Front Neurosci. 2017. PMID: 28487626 Free PMC article.
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